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	<title>short &#8211; USA NEWS LIVE</title>
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	<title>short &#8211; USA NEWS LIVE</title>
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		<title>Eli Lilly strikes the profits, also as weight reduction, diabetes drug sales are too short</title>
		<link>https://bloggingthree.soflytech.com/2025/02/eli-lilly-strikes-the-profits-also-as-weight-reduction-diabetes-drug-sales-are-too-short/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Wed, 12 Feb 2025 03:41:58 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[diabetes]]></category>
		<category><![CDATA[drug]]></category>
		<category><![CDATA[Eli]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=24401</guid>

					<description><![CDATA[Eli Lilly reported on Thursday Mixed results For the fourth quarter, also because the demand for the blockbuster weight reduction medication zepbound and diabetes treatment of Mounjaro. The company&#39;s quarterly profit estimated Wall Street, but sales were only briefly, since Mounjaro recorded lower prices. Zepbound and Mounjaro now have the expectations in two quarters below [&#8230;]]]></description>
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<p>Eli Lilly reported on Thursday <a href="https://investor.lilly.com/news-releases/news-release-details/lilly-reports-full-q4-2024-financial-results-and-provides-2025" target="_blank">Mixed results</a> For the fourth quarter, also because the demand for the blockbuster weight reduction medication zepbound and diabetes treatment of Mounjaro.</p>
<p>The company&#39;s quarterly profit estimated Wall Street, but sales were only briefly, since Mounjaro recorded lower prices. Zepbound and Mounjaro now have the expectations in two quarters below average, and the corporate previously identified problems as a part of the inventory amongst wholesale dealers.</p>
<p>The pharmaceutical giant also gave the profit line of $ 22.05 to $ 23.55 per share for the fiscal 2025 USD, which corresponds to the analysts. Eli Lilly confirmed his sales advice of 58 to 61 billion US dollars for the 2025 financial 12 months and located that it&#8217;s going to be launched all 12 months round in recent international markets in recent international markets.</p>
<p>Eli Lilly expects &#8220;a continuation of the entire prescription growth that we saw in 2024&#8221; for Inkrein medication equivalent to Zepbound and Mounjaro &#8220;. Said during a win on Thursday.</p>
<p>Eli Lilly&#39;s shares rose by more than 4%on Thursday.</p>
<p>The figures agreed with the preliminary results that Eli Lilly shared in January that disappointed investors. Eli Lilly had reduced his intake of 2024 because the demand for weight loss and diabetes medication would not meet its high expectations.</p>
<p>In particular, Eli Lilly said that it is planning to report data in the next generation this year, a few months earlier than expected, in the late stage. Retatrutid works differently than the treatments on the market and imitates three different hunger regulatory hormones: GLP-1, Gip and Glucagon.</p>
<p>The following reported Eli Lilly in the fourth quarter compared to the expectations of Wall Street, based on a survey of LSEG analysts: </p>
<ul>
<li><strong>Win each share: </strong>$ 5.32 adapted compared to USD 4.95</li>
<li><strong>Revenue: </strong>13.53 billion US dollars expected compared to $ 13.57 billion</li>
</ul>
<p>The company generated sales of $ 13.53 billion in the fourth quarter, which rose to an increase of 45% compared to the same period in the previous year. </p>
<p>In the fourth quarter, the pharmaceutical booked a net income of 4.41 billion US dollars or $ 4.88 per share. This is compared to a profit of 2.19 billion US dollars or $ 2.42 per share in the previous year. </p>
<p>Without unique elements associated with the value of intangible assets and other adjustments, Eli Lilly achieved the result of $ 5.32 per share for the fourth quarter of 2024.</p>
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<h2 class="ArticleBody-subtitle"><a id="headline0"></a>Zepbound, Mounjaro Performance</h2>
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<p>Mounjaro achieved sales of $ 3.53 billion in the fourth quarter, which rose by 60% of the same period in the previous year. According to StreetCcount, the analysts had expected that the drug would book sales of 3.62 billion US dollars for the quarter.  </p>
<p>Eli Lilly said that the increase reflects a strong demand and an increased range of Mounjaro, but was partially compensated for by lower -scale prices due to &#8220;low-cost changes&#8221; in the fourth quarter of 2023 at estimates for discounts and discounts. </p>
<p>In the meantime, the results of Zepbound&#39;s first full year are limited to the US market. The weekly injection generated sales of 1.91 billion US dollars in the fourth quarter, which, according to StreetCcount, is among the expected analysts among the expected analysts. </p>
<p>Montarce said Zepbound had become the market leader in the obesity market in the fourth quarter, measured by new recipes.</p>
<p>However, demand in the United States exceeded the offer for Eli Lillys Incretin medication such as Zepbound and Mounjaro last year. Both treatments imitate certain intestinal hormones to reduce the appetite of a person and regulate their blood sugar.</p>
<p>Eli Lilly and his rivals have forced the popularity of this injectable drugs <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-6">Novo Nordisk<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>    Invested billions to improve the production capacity for your treatments. The efforts seem to be able to pay off: The Food and Drug Administration in December confirmed its decision to explain the US deficiency in Tirepatide &#8211; the active ingredient in Zepbound and Mounjaro.</p>
<p>On Thursday, Eli Lilly estimated that in the first half of 2025 compared to the first half of 2024 it will produce at least 1.6 times the incorrect doses.</p>
<p>The turnover of Eli Lilly&#39;s older diabetes medication exceeded estimates for the fourth quarter. Jardiance achieved sales of $ 1.20 billion for the period, which rose by 50% of the previous year. According to estimates, which were compiled by StreetCOUNT, analysts expected sales of $ 901.5 million. </p>
<p>This growth includes a one-off advantage of $ 300 million due to a change in the collaboration of Eli Lilly with his Jardiance partner Boehringer Ingelheim.</p>
<p>The results also start a critical year for Eli Lilly, in which closely observed clinical test data on his experimental obesity pill, Orforlipron, are to be released. These results are expected by the middle of the year.</p>
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<h2 class="RelatedContent-header">Do not miss these findings from CNBC Pro</h2>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>Putin apologizes to Azerbaijan for &#8220;tragic&#8221; plane crash but stops in need of taking responsibility</title>
		<link>https://bloggingthree.soflytech.com/2024/12/putin-apologizes-to-azerbaijan-for-tragic-plane-crash-but-stops-in-need-of-taking-responsibility/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Sat, 28 Dec 2024 22:18:32 +0000</pubDate>
				<category><![CDATA[Travel]]></category>
		<category><![CDATA[apologizes]]></category>
		<category><![CDATA[Azerbaijan]]></category>
		<category><![CDATA[crash]]></category>
		<category><![CDATA[plane]]></category>
		<category><![CDATA[Putin]]></category>
		<category><![CDATA[responsibility]]></category>
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		<category><![CDATA[Tragic]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=21733</guid>

					<description><![CDATA[Russian President Vladimir Putin apologized to the President of Azerbaijan for this Civilian aircraft crash The Kremlin said on Saturday that 38 people were killed, without admitting responsibility. “Vladimir Putin apologized for that A tragic incident occurred in Russian airspace“said the Kremlin. The plane “repeatedly tried to land at Grozny airport,” Putin told Ilham Aliyev, [&#8230;]]]></description>
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<p>Russian President Vladimir Putin apologized to the President of Azerbaijan for this <a href="https://www.nbcnews.com/news/world/azerbaijan-airlines-crash-external-interference-kazakh-russia-ukraine-rcna185518" target="_blank">Civilian aircraft crash</a> The Kremlin said on Saturday that 38 people were killed, without admitting responsibility.</p>
<p>“Vladimir Putin apologized for that <a href="https://www.nbcnews.com/news/world/kremlin-warns-speculation-russia-shot-azerbaijan-airlines-flight-rcna185427" target="_blank">A tragic incident occurred in Russian airspace</a>“said the Kremlin.</p>
<p>The plane “repeatedly tried to land at Grozny airport,” Putin told Ilham Aliyev, who was “attacked” on the time <a href="https://www.nbcnews.com/news/world/ukraine-uses-dragon-drones-spew-feiry-substance-russias-frontlines-rcna170193" target="_blank">Ukrainian combat drones</a>.&#8221;</p>
<p>Russian air defense systems “repelled these attacks,” Putin said.</p>
<p>He did not say whether the plane was hit <a href="https://www.nbcnews.com/now/video/u-s-intelligence-believes-russia-misidentified-and-shot-down-azerbaijani-airliner-228026437732" goal="_blank">Russian air defense</a> but the Kremlin said<strong> </strong>that an investigation was underway and civilian and military specialists were being questioned.</p>
<p>The Azerbaijan Airlines plane crashed near the city of Aktau in Kazakhstan on Christmas Day.<a href="https://www.nbcnews.com/video/passengers-on-crashed-azerbaijan-plane-describe-explosions-228027973788" goal="_blank"> 38 of the 67 people on board were killed</a>.</p>
<p>According to a readout from Aliyev&#39;s office, Azerbaijani President Putin shared evidence indicating &#8220;external physical and technical interference&#8221; and stated that it took place in Russian airspace.</p>
<p>Aliyev mentioned several holes in the plane&#39;s fuselage, injuries to passengers and crew members &#8220;resulting from foreign particles that entered the cabin throughout the flight,&#8221; and statements from surviving passengers and crew members, some of whom had claimed this <a href="https://www.nbcnews.com/video/passengers-on-crashed-azerbaijan-plane-describe-explosions-228027973788" goal="_blank">felt explosions </a>before the plane crashed.</p>
<p>Two U.S. military officials told NBC News on Friday that the plane may have been hit by Russian missiles, saying they had information suggesting the Russians may have misidentified the plane and shot it down.</p>
<p>Intelligence suggested the Russians believed the plane was a drone, partly due to an irregular flight pattern, the officials said.</p>
<p>The Embraer 190 was subjected to &#8220;physical and technical interference from outside,&#8221; the airline said on Friday, as the plane was en route from the Azerbaijani capital Baku to Grozny, the capital of the Russian region of Chechnya.</p>
<p>Russian officials have warned against speculating about the cause of the crash, and on Saturday Kremlin spokesman Dmitry Peskov said Russia was &#8220;awaiting the outcomes of the investigation.&#8221;</p>
<p>However, the country&#39;s aviation ministry, Rosaviatsia, previously said that the situation around the destination airport of Grozny was &#8220;very complicated&#8221; resulting from the presence of Ukrainian drones nearby.</p>
<p>Rosaviatsia also said that at an altitude of 1,600 feet there was thick fog and no visibility and the pilot finally decided to divert after two unsuccessful attempts to land in Grozny.</p>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>An 83-year-old short story by Borges heralds a bleak future for the Internet</title>
		<link>https://bloggingthree.soflytech.com/2024/11/an-83-year-old-short-story-by-borges-heralds-a-bleak-future-for-the-internet/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Tue, 19 Nov 2024 16:24:52 +0000</pubDate>
				<category><![CDATA[Arts]]></category>
		<category><![CDATA[83yearold]]></category>
		<category><![CDATA[bleak]]></category>
		<category><![CDATA[Borges]]></category>
		<category><![CDATA[future]]></category>
		<category><![CDATA[heralds]]></category>
		<category><![CDATA[internet]]></category>
		<category><![CDATA[short]]></category>
		<category><![CDATA[story]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=19420</guid>

					<description><![CDATA[How will the Internet develop in the approaching a long time? Fiction writers have explored a couple of possibilities. In his 2019 novel “Falling“, science fiction writer Neal Stephenson I imagined a near future where the Internet still exists. But it&#8217;s so contaminated with misinformation, disinformation and promoting that it is basically useless. The characters [&#8230;]]]></description>
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<p>How will the Internet develop in the approaching a long time?</p>
<p>Fiction writers have explored a couple of possibilities.</p>
<p>In his 2019 novel “<a href="https://www.nealstephenson.com/fall,-or-dodge-in-hell.html">Falling</a>“, science fiction writer <a href="https://www.librarything.com/author/stephensonneal">Neal Stephenson</a> I imagined a near future where the Internet still exists. But it&#8217;s so contaminated with misinformation, disinformation and promoting that it is basically useless.</p>
<p>The characters in Stephenson&#39;s novel address this problem by subscribing to &#8220;edit streams&#8221; &#8211; human-selected news and data that may be considered trustworthy.</p>
<p>The downside is that only the rich can afford such tailored services, leaving most of humanity to devour low-quality, uncurated online content.</p>
<p>To some extent, this has already happened: many news organizations like The New York Times and The Wall Street Journal have placed their curated content behind paywalls. In the meantime, <a href="https://www.nytimes.com/2022/10/13/technology/misinformation-integrity-institute-report.html">Misinformation is bubbling</a> on social media platforms like X and TikTok.</p>
<p>Stephenson&#39;s track record as a prognosticator was impressive &#8211; he anticipated the metaverse in his 1992 novel.<a href="https://www.penguinrandomhouse.com/books/172832/snow-crash-by-neal-stephenson/">Snow accident</a>” and a central plot element of his “<a href="https://www.penguinrandomhouse.com/books/172835/the-diamond-age-by-neal-stephenson/">Diamond Age</a>&#8220;, published in 1995, is an interactive introduction that works <a href="https://www.theatlantic.com/technology/archive/2024/02/chatbots-ai-neal-stephenson-diamond-age/677364/">much like a chatbot</a>.</p>
<p>On the surface, chatbots look like an answer to the misinformation epidemic. By providing factual content, chatbots could provide alternative sources of quality information that usually are not blocked off by paywalls. </p>
<p>Ironically, nevertheless, the outcomes of those chatbots pose perhaps the best danger to the longer term of the net &#8211; a danger already suggested a long time earlier by an Argentine author <a href="https://www.nytimes.com/1986/06/15/obituaries/jorge-luis-borges-a-master-of-fantasy-and-fable-is-dead.html">Jorge Luis Borges</a>.</p>
<h2>The rise of chatbots</h2>
<p>Today, a good portion of the Internet still consists of factual and ostensibly truthful content, equivalent to articles and books which have been peer-reviewed, fact-checked, or verified ultimately. </p>
<p>The developers of huge language models, or LLMs—the engines that power bots like ChatGPT, Copilot, and Gemini—have taken advantage of this resource. </p>
<p>However, to work their magic, these models must eat <a href="https://analyticsindiamag.com/ai-origins-evolution/behind-chatgpts-wisdom-300-bn-words-570-gb-data/">immense amounts</a> high-quality texts for training purposes. A considerable amount of vocabulary has already been picked from online sources and fed to the young LLMs.</p>
<p>The problem is that the Internet, as vast because it is, is a finite resource. High-quality text that has not already been strip-mined <a href="https://www.theatlantic.com/technology/archive/2023/01/artificial-intelligence-ai-chatgpt-dall-e-2-learning/672754/">grow to be scarce</a>which led to what the New York Times called &#8220;<a href="https://www.nytimes.com/2024/07/19/technology/ai-data-restrictions.html">looming substantive crisis</a>.”</p>
<p>This has forced firms like OpenAI to achieve this <a href="https://www.axios.com/2024/05/29/atlantic-vox-media-openai-licensing-deal">make agreements</a> with publishers to get much more raw material for his or her voracious bots. However, based on one forecast, there could possibly be a shortage of additional high-quality training data as early as 2026.</p>
<p>When chatbot results find yourself online, these second-generation texts – complete with made-up information called “<a href="https://medium.com/analytics-matters/generative-ai-its-all-a-hallucination-6b8798445044">Hallucinations</a>“in addition to outright errors, equivalent to suggestions to place glue in your pizza – will proceed to pollute the web.</p>
<p>And if a chatbot hangs out with the fallacious people online, it could pick up on their repugnant views. Microsoft discovered this the hard way in 2016 when <a href="https://blogs.microsoft.com/blog/2016/03/25/learning-tays-introduction/">Tay had to tug the plug</a>a bot that began repeating itself <a href="https://www.nytimes.com/2016/03/25/technology/microsoft-created-a-twitter-bot-to-learn-from-users-it-quickly-became-a-racist-jerk.html">racist and sexist content</a>.</p>
<p>Over time, all of those issues may lead to online content becoming more balanced <a href="https://www.fastcompany.com/91220148/marketers-in-a-dying-internet-why-the-only-option-is-a-return-to-simplicity">less trustworthy</a> and fewer useful than today. Additionally, LLMs fed a low-calorie weight-reduction plan can result in much more problematic results that also find yourself on the web.</p>
<h2>An limitless – and useless – library</h2>
<p>It&#39;s not hard to assume a feedback loop resulting in a continuous technique of degradation because the bots feed on their very own incomplete results.</p>
<p><a href="https://doi.org/10.1038/s41586-024-07566-y">An article from July 2024</a> The project, published in Nature, examined the results of coaching AI models on recursively generated data. It turned out that “irreversible defects” result in “<a href="https://openreview.net/forum?id=ShjMHfmPs0">Model collapse</a>” for systems trained this fashion – much like how a duplicate of a picture and a duplicate of that replicate and a duplicate of that replicate lose fidelity to the unique image.</p>
<p>How bad could this get?</p>
<p>Consider Borges&#39; 1941 short story &#8220;<a href="https://sites.evergreen.edu/politicalshakespeares/wp-content/uploads/sites/226/2015/12/Borges-The-Library-of-Babel.pdf">The Library of Babel</a>.” Fifty years before the pc scientist <a href="https://www.britannica.com/biography/Tim-Berners-Lee">Tim Berners Lee</a> While Borges was creating the architecture for the net, he had already imagined an analog equivalent.</p>
<p>In his 3,000-word story, the writer imagines a world made up of an enormous and possibly infinite variety of hexagonal rooms. The bookshelves in each room contain uniform volumes that, as their occupants suspect, must contain every possible combination of letters of their alphabet.</p>
<figure class="align-center ">
<div class="placeholder-container" style="--aspect-ratio-percent:57.161803713527846%;--background-color:#504b28"><img decoding="async" alt="Illustration of connected golden hexagons stretching endlessly to the horizon." class="lazyload" src="https://images.theconversation.com/files/631801/original/file-20241113-17-oasuap.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/631801/original/file-20241113-17-oasuap.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=343&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/631801/original/file-20241113-17-oasuap.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=343&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/631801/original/file-20241113-17-oasuap.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=343&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/631801/original/file-20241113-17-oasuap.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=431&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/631801/original/file-20241113-17-oasuap.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=431&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/631801/original/file-20241113-17-oasuap.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=431&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">In Borges&#39; imaginary, endlessly extensive library of content, trying to find something meaningful is like searching for a needle in a haystack.</span><br />
              <span class="attribution"><a class="source" href="https://www.gettyimages.com/detail/photo/group-of-repeating-hexagonal-figures-in-a-3d-royalty-free-image/2171625976?phrase=hexagon%20pattern%20books&#038;searchscope=image%2Cfilm&#038;adppopup=true">aire images/Moment via Getty Images</a></span><br />
            </figcaption></figure>
<p>This realization initially triggers joy: by definition, there should be books that describe the longer term of humanity and the meaning of life intimately.</p>
<p>The residents search for such books and find that almost all of them only contain meaningless mixtures of letters. The truth is on the market &#8211; but so is every untruth possible. And all of that is embedded in an unimaginably great amount of nonsense.</p>
<p>Even after centuries of searching, only a couple of meaningful fragments are found. And even then, there isn&#8217;t any approach to determine whether these related texts are truths or lies. Hope turns into despair.</p>
<p>Is the Internet becoming so polluted that only the wealthy can afford accurate, reliable information? Or will an infinite variety of chatbots produce so many corrupt expressions that trying to find correct information on the Internet might be like searching for a needle in a haystack?</p>
<p>The Internet is commonly described as certainly one of humanity&#39;s great achievements. But like several other resource, it will be important to significantly take into consideration the way it is cared for and managed – lest we find yourself with Borges’ dystopian vision.</p>
</p></div>
<p><em>image credit : theconversation.com</em></p>
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		<title>Even short trips into space can change an astronaut&#039;s biology &#8211; a brand new series of studies offers essentially the most comprehensive insight into the health of astronauts during space flights since NASA&#039;s twin study</title>
		<link>https://bloggingthree.soflytech.com/2024/07/even-short-trips-into-space-can-change-an-astronauts-biology-a-brand-new-series-of-studies-offers-essentially-the-most-comprehensive-insight-into-the-health-of-astronauts-during-space-flights-s/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Thu, 04 Jul 2024 06:03:40 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[astronaut39s]]></category>
		<category><![CDATA[astronauts]]></category>
		<category><![CDATA[biology]]></category>
		<category><![CDATA[change]]></category>
		<category><![CDATA[comprehensive]]></category>
		<category><![CDATA[flights]]></category>
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		<category><![CDATA[insight]]></category>
		<category><![CDATA[NASA39s]]></category>
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		<category><![CDATA[twin]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=8089</guid>

					<description><![CDATA[Only about 600 people have ever traveled into space. The overwhelming majority of astronauts For the past sixty years, the soldiers have been middle-aged men on short-term missions of lower than twenty days. Today, we&#8217;re witnessing a brand new era of human spaceflight as more private, industrial and multinational space operators and aviators enter the [&#8230;]]]></description>
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<p>Only about 600 people have ever traveled into space. <a href="https://doi.org/10.1016/j.actaastro.2020.06.004">The overwhelming majority of astronauts</a> For the past sixty years, the soldiers have been middle-aged men on short-term missions of lower than twenty days.</p>
<p>Today, we&#8217;re witnessing a brand new era of human spaceflight as more private, industrial and multinational space operators and aviators enter the market, with missions lasting from minutes, hours and days to months. </p>
<p>As humanity hopes to return to the moon in the approaching decade, space missions will last significantly longer and can involve many more astronauts and even space tourists. This also implies that a greater diversity of individuals will experience the acute conditions of space &#8211; more women and folks of various ethnicities, ages and health conditions. </p>
<p>Because people respond in another way to the unique stressors and pressures of space, space health researchers like me try to raised understand the impact of spaceflight on human health. With such information, we will work out the way to help astronauts stay healthy each in space and after they return to Earth.</p>
<p>As a part of the <a href="https://doi.org/10.1126/science.aau8650">historical NASA twin study</a>In 2019, my colleagues and I published groundbreaking research on how a 12 months aboard the International Space Station affects the human body.</p>
<p>I&#8217;m a <a href="https://scholar.google.com/citations?user=nvFtqMoAAAAJ&#038;hl=en">Radiation cancer biologist</a> within the Department of Environmental and Radiation Health Sciences at Colorado State University. I even have spent the previous few years expanding on this earlier research in a series of recent articles <a href="https://www.nature.com/immersive/d42859-024-00009-8/index.html">published in your entire Nature journal portfolio</a>. </p>
<p>These papers are a part of the <a href="https://www.nature.com/immersive/d42859-024-00009-8/index.html">Manuscript package “Space Omics and Medical Atlas”</a>Data, protocols and repositories representing the biggest collection ever assembled for aerospace medicine and space biology. Over 100 institutions from 25 countries have contributed to the coordinated release of a wide selection of space data.</p>
<h2>The NASA twin study</h2>
<p>NASA <a href="https://doi.org/10.1126/science.aau8650">Twin study</a> seized a singular research opportunity. </p>
<p>NASA chosen astronaut Scott Kelly for the agency&#39;s first year-long mission, during which he spent a 12 months aboard the International Space Station from 2015 to 2016. During the identical period, his an identical twin brother Mark Kelly, a former astronaut and current U.S. Senator for Arizona, remained on Earth. </p>
<figure class="align-center zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:58.753315649867375%;--background-color:#4f452e"><img decoding="async" alt="Two identical men in blue overalls stand next to each other." class="lazyload" src="https://images.theconversation.com/files/603242/original/file-20240626-19-lhf9r7.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/603242/original/file-20240626-19-lhf9r7.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=353&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/603242/original/file-20240626-19-lhf9r7.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=353&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/603242/original/file-20240626-19-lhf9r7.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=353&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/603242/original/file-20240626-19-lhf9r7.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=443&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/603242/original/file-20240626-19-lhf9r7.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=443&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/603242/original/file-20240626-19-lhf9r7.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=443&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">NASA astronaut Scott Kelly (left), who flew into space as a part of the NASA twin study, stands next to his twin brother Mark Kelly, who remained on Earth.</span><br />
              <span class="attribution"><a class="source" href="https://newsroom.ap.org/detail/YearInSpaceRetirement/0f1ae340e62b48af8e9fa3e7268d392f/photo?Query=nasa%20twins%20study&#038;mediaType=photo&#038;sortBy=&#038;dateRange=Anytime&#038;totalCount=6&#038;currentItemNo=2">AP Photo/Pat Sullivan</a></span><br />
            </figcaption></figure>
<p>My team and I examined blood samples collected before, during and after spaceflight from our twin and his genetically an identical twin on Earth. We found that Scott&#39;s telomeres &#8211; the protective caps on the ends of chromosomes which can be just like the plastic tip on a shoelace that keeps them from fraying &#8211; grew unexpectedly longer during his 12 months in space.</p>
<p>When Scott returned to Earth, nonetheless, his telomeres began to shorten rapidly. In the months that followed, his telomeres recovered, but were still shorter after his trip than that they had been before his flight into space. </p>
<p>As you age, your telomeres shorten on account of various aspects, including stress. The length of your telomeres can <a href="https://doi.org/10.1038/s41556-022-00842-x">function a biological indicator</a> Your risk of developing age-related diseases equivalent to dementia, heart problems and cancer. </p>
<p><a href="https://doi.org/10.1016/j.celrep.2020.108435">In a separate study</a>My team studied a bunch of 10 astronauts on six-month missions aboard the International Space Station. We also had a control group of age- and gender-matched participants who stayed on Earth. </p>
<p>We measured telomere length before, during and after spaceflight and again found that telomeres were longer during spaceflight and shortened after returning to Earth. Overall, the astronauts had many more short telomeres after spaceflight than before. </p>
<p>One of the opposite researchers within the twin study, <a href="https://scholar.google.com/citations?user=vId_OTEAAAAJ&#038;hl=en">Christopher Mason</a>and me <a href="https://doi.org/10.1016/j.celrep.2020.108457">conducted one other telomere study</a> – this time with two high-altitude mountaineers – a similarly extreme environment as on Earth. </p>
<p>We found that the climbers&#39; telomeres were longer after they climbed Mount Everest and shortened again after they descended. Their twins who stayed at low altitude didn&#8217;t experience the identical changes in telomere length. These results suggest that it was not the microgravity of the space station that caused the changes in telomere length we observed within the astronauts &#8211; other causes, equivalent to increased radiation exposure, are more likely. </p>
<h2>Civilians in space</h2>
<p><a href="https://doi.org/10.1093/pcmedi/pbae007">In our latest study</a>We studied the telomeres of the crew aboard SpaceX&#39;s 2021 Inspiration4 mission. This mission had the primary all-civilian crew whose ages spanned 4 a long time. All crew members&#39; telomeres lengthened through the mission, and three of the 4 astronauts also showed telomere shortening after returning to Earth. </p>
<figure class="align-center zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:66.71087533156499%;--background-color:#453936"><img decoding="async" alt="Four people in black overalls wave their hands in the air." class="lazyload" src="https://images.theconversation.com/files/603245/original/file-20240626-19-nz37j1.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/603245/original/file-20240626-19-nz37j1.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/603245/original/file-20240626-19-nz37j1.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/603245/original/file-20240626-19-nz37j1.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/603245/original/file-20240626-19-nz37j1.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=503&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/603245/original/file-20240626-19-nz37j1.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=503&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/603245/original/file-20240626-19-nz37j1.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=503&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">The crew members of the SpaceX Inspiration4 2021 mission.</span><br />
              <span class="attribution"><a class="source" href="https://www.flickr.com/photos/spacex/51493859148">SpaceX</a>, <a class="license" href="http://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC</a></span><br />
            </figcaption></figure>
<p>What&#39;s particularly interesting about these findings is that the Inspiration4 mission lasted only three days. So not only do scientists now have consistent and reproducible data on how telomeres reply to spaceflight, but we also know that it happens quickly. These results suggest that even short trips, like a weekend trip to space, are related to changes in telomere length. </p>
<p>The health implications of such changes in telomere length should not yet fully understood by scientists. We have to do more research to know how each long and short telomeres affect an astronaut&#39;s long-term health.</p>
<h2>Telomere RNA</h2>
<p><a href="https://doi.org/10.1038/s42003-024-06014-x">In one other article</a>we showed that the Inspiration4 crew – in addition to Scott Kelly and the high-altitude climbers – had elevated levels of telomeric RNA, called TERRA. </p>
<p>Telomeres consist of various repeating DNA sequences. These are transcribed into TERRA, which contributes to the structure of the telomeres and helps them perform their function. </p>
<p>Together with laboratory studies, these results show that telomeres are damaged during space travel. Although there continues to be much we have no idea, we do know that telomeres are particularly sensitive to <a href="https://www.healthline.com/health/oxidative-stress">oxidative stress</a>The chronic oxidative damage that astronauts suffer from 24/7 exposure to space radiation likely contributes to the telomere responses we observe. </p>
<p>We also wrote a <a href="https://doi.org/10.1007/s10522-024-10098-7">Review article with a more futuristic perspective</a> how a greater understanding of telomeres and aging could help humans not only survive long space journeys, but in addition thrive and even colonize other planets. This would require humans to breed in space and future generations to grow up in space. We don&#39;t yet know if that is even possible.</p>
<h2>Plant telomeres in space</h2>
<p>My colleagues and I even have also contributed other work to the Space Omics and Medical Atlas package, including <a href="https://doi.org/10.1038/s41467-023-41510-4">an article published in Nature Communications</a>The study team led by Texas A&#038;M biologist <a href="https://scholar.google.com/citations?user=nHjDBNIAAAAJ&#038;hl=en">Dorothy Shippen</a> and biologist at Ohio University <a href="https://scholar.google.com/citations?user=yXhk2d4AAAAJ&#038;hl=en">Sarah Wyatt</a>found that plants in space didn&#8217;t have longer telomeres during their time aboard the International Space Station, unlike humans. </p>
<p>However, the plants increased their <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/telomerase">Production of telomerase</a>the enzyme that helps maintain telomere length. </p>
<p>As anyone who has seen “<a href="https://www.imdb.com/title/tt3659388/">The Martian</a>&#8220;As we all know, plants will play an essential role in the long-term survival of humans in space. This finding suggests that plants may be naturally better equipped to withstand the stresses of space than humans.&#8221;</p>
</p></div>
<p><em>image credit : theconversation.com</em></p>
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		<title>Most doses of Eli Lilly&#039;s Zepbound, Mounjaro are briefly supply through June, in keeping with the FDA</title>
		<link>https://bloggingthree.soflytech.com/2024/04/most-doses-of-eli-lillys-zepbound-mounjaro-are-briefly-supply-through-june-in-keeping-with-the-fda/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Mon, 22 Apr 2024 06:53:33 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[doses]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=1208</guid>

					<description><![CDATA[Most doses of Eli LillyHugely popular weight reduction drug Zepbound and its diabetes counterpart Mounjaro shall be briefly supply within the second quarter of this 12 months as demand increases, in keeping with a study To update within the Food and Drug Administration&#39;s drug shortage database on Wednesday. All doses of Zepbound and Mounjaro except [&#8230;]]]></description>
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<div id="RegularArticle-ArticleBody-5" data-module="ArticleBody" data-test="articleBody-2" data-analytics="RegularArticle-articleBody-5-2"><span class="HighlightShare-hidden" style="top:0;left:0"></span></p>
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<p>Most doses of <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-1">Eli Lilly<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>Hugely popular weight reduction drug Zepbound and its diabetes counterpart Mounjaro shall be briefly supply within the second quarter of this 12 months as demand increases, in keeping with a study <a href="https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&amp;st=c" target="_blank" rel="noopener">To update</a> within the Food and Drug Administration&#39;s drug shortage database on Wednesday. </p>
<p>All doses of Zepbound and Mounjaro except the two.5-milligram versions of each treatments are briefly supply.  A <a href="https://www.reuters.com/business/healthcare-pharmaceuticals/some-doses-lillys-zepbound-short-supply-through-april-end-us-fda-says-2024-04-03/" target="_blank" rel="noopener">previous update</a> said some doses of each drugs can be in limited supply through April.</p>
<p>The latest update suggests that insatiable demand for a preferred class of weight reduction and diabetes drugs continues to be undermining supply, at the same time as Eli Lilly and its essential competitor, <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-6">Novo Nordisk<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>are working to extend production of those treatments. </p>
<p>Many patients are struggling to search out injectable treatments, which have surged in demand because they may also help them lose significant kilos over time.  These treatments are sometimes called incretin medications, which mimic gut hormones to suppress appetite and regulate blood sugar.</p>
<p>“We recognize that this situation may cause disruption to people’s treatment plans, and that is what we are doing.”<br />“We are working diligently and urgently to meet the surge in demand,” an Eli Lilly spokesperson said in an announcement to CNBC.  The company expects its investments in manufacturing and delivery capabilities to “gradually increase production of our medicines throughout 2024 and beyond,” they said.</p>
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<p>Eli Lilly said in February it had met its goal of doubling production capability for such incretin drugs by the top of 2023.  The company said it might expand production with “equal urgency” this 12 months, with essentially the most significant increases coming within the second half of the 12 months. </p>
<p>By then, the corporate expects production of salable doses of incretin drugs to be a minimum of 1.5 times higher than within the second half of 2023.</p>
<p>Eli Lilly also announced that a brand new facility in Concord, North Carolina, will begin producing incretin drugs as early as the top of the 12 months, with products expected to ship in 2025.  The company may even construct a handful of additional facilities later this 12 months over the following few years, including a site in Germany and two latest plants in its home state of Indiana. </p>
<p>Novo Nordisk has announced similar efforts.  According to the FDA&#39;s website, some doses of the weight-loss drug Wegovy and its diabetes counterpart Ozempic are also briefly supply.</p>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>In many states, including Colorado, marijuana tax revenues are falling wanting forecasts</title>
		<link>https://bloggingthree.soflytech.com/2024/04/in-many-states-including-colorado-marijuana-tax-revenues-are-falling-wanting-forecasts/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Tue, 16 Apr 2024 11:09:37 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[Colorado]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=633</guid>

					<description><![CDATA[Nearly half of Americans Live in a state that permits legal access to recreational marijuana. There are eleven other states, including Wisconsin and Florida is considering legalization in 2024. One of essentially the most common reasons for legalizing marijuana is Increase in state tax revenue. The amount of revenue depends upon states&#39; decisions about regulating [&#8230;]]]></description>
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<p>Nearly <a href="https://www.pewresearch.org/short-reads/2024/02/29/most-americans-now-live-in-a-legal-marijuana-state-and-most-have-at-least-one-dispensary-in-their-county/">half of Americans</a> Live in a state that permits legal access to recreational marijuana.  There are eleven other states, including Wisconsin and Florida <a href="https://www.cannabisbusinesstimes.com/news/states-that-may-legalize-cannabis-in-2024/">is considering legalization in 2024</a>. </p>
<p>One of essentially the most common reasons for legalizing marijuana is <a href="https://www.forbes.com/sites/kriskrane/2020/05/26/cannabis-legalization-is-key-to-economic-recovery-much-like-ending-alcohol-prohibition-helped-us-out-of-the-great-depression/?sh=48a3740c3241">Increase in state tax revenue</a>.  The amount of revenue depends upon states&#39; decisions about regulating the marijuana industry, including the way it is taxed.</p>
<p><a href="https://scholar.google.com/citations?user=LWDktScAAAAJ&#038;hl=en">I&#8217;m an economist</a> He focuses on predicting how different tax systems will affect markets.  My expertise includes industries corresponding to legal recreational marijuana, alcohol and tobacco.  I examined various taxes on marijuana in states like Colorado and Washington to know how much revenue was generated and what role state tax policies played.</p>
<h2>Marijuana is taxed similarly to alcohol and tobacco</h2>
<p>Taxes on recreational marijuana are generally based on price, quantity, weight or potency – just like other “sin goods” corresponding to tobacco and alcohol products. </p>
<p><a href="https://www.urban.org/policy-centers/cross-center-initiatives/state-and-local-finance-initiative/state-and-local-backgrounders/marijuana-taxes">Taxation of sin goods</a> is assumed <a href="https://iris.who.int/bitstream/handle/10665/207052/9290611715_eng.pdf">shape public health policy</a> and reduce the harmful effects of those products on the general public.  These taxes, also called excise taxes, are typically higher on sin goods than taxes on other products.</p>
<p>The aggressive taxation of those goods is about greater than just government greed.  It is common knowledge that consuming alcohol and tobacco <a href="https://doi.org/10.1007/s40273-021-01031-8">creates burdens for society</a> corresponding to increased violence and health care costs.  Economists like me check with these impacts on innocent people as “negative social externalities.”</p>
<p>Studies have shown that marijuana can have effects <a href="https://doi.org/10.1002/wps.20735">harmful health risks</a>to &#8211; <a href="https://doi.org/10.1093/cercor/bhw015">especially amongst young people</a>.  Therefore, governments often impose taxes on marijuana to limit its use.</p>
<p>Most states where marijuana is legal impose a marijuana sales tax.  Other <a href="https://taxfoundation.org/data/all/state/state-recreational-marijuana-taxes-2023/">use a mix</a> Sales tax and a quantity or weight-dependent tax.  For example, a half-dozen marijuana brownies that weigh one pound could possibly be taxed as a “six,” or by their weight. </p>
<p>Potency taxes, a standard practice in taxing liquor in most states, also aim to cut back consumption. <a href="https://www.urban.org/policy-centers/cross-center-initiatives/state-and-local-finance-initiative/state-and-local-backgrounders/marijuana-taxes">Taxes on liquor</a> are often significantly higher than the taxes on wine and beer.  Marijuana potency could be taxed based on the product&#39;s THC content, the most important psychoactive compound in cannabis.</p>
<figure class="align-center zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:66.57824933687002%;--background-color:#9d695f"><img decoding="async" alt="White man displays marijuana products in a well-lit dispensary surrounded by other marijuana products" class="lazyload" src="https://images.theconversation.com/files/586199/original/file-20240404-18-g7k3zc.jpg?ixlib=rb-1.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/586199/original/file-20240404-18-g7k3zc.jpg?ixlib=rb-1.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/586199/original/file-20240404-18-g7k3zc.jpg?ixlib=rb-1.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/586199/original/file-20240404-18-g7k3zc.jpg?ixlib=rb-1.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/586199/original/file-20240404-18-g7k3zc.jpg?ixlib=rb-1.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=502&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/586199/original/file-20240404-18-g7k3zc.jpg?ixlib=rb-1.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=502&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/586199/original/file-20240404-18-g7k3zc.jpg?ixlib=rb-1.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=502&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">A budtender presents the products at Native Roots, one in every of the larger dispensaries in Colorado.</span><br />
              <span class="attribution"><a class="source" href="https://www.gettyimages.com/detail/news-photo/bryce-white-a-bud-tender-at-native-roots-dispensary-shows-a-news-photo/1094061546">Matt Jonas/Digital First Media/Boulder Daily Camera via Getty Images</a></span><br />
            </figcaption></figure>
<h2>Why state tax revenue was so low</h2>
<p>In 2012, <a href="https://leg.colorado.gov/sites/default/files/14_marijuanalegis.pdf">Colorado</a> And <a href="https://leg.wa.gov/house/committees/oprgeneral/documents/2012/i-502%20summary.pdf">Washington</a> were the primary two states to legalize recreational marijuana, and sales began in 2014. These states aggressively tax marijuana in comparison with other states.</p>
<p>For example, Colorado imposes <a href="https://tax.colorado.gov/marijuana-sales-tax">a 15% sales tax on marijuana</a>paid by consumers, and an additional 15% by weight paid by retailers – in comparison with <a href="https://www.tax.newmexico.gov/businesses/wp-content/uploads/sites/4/2022/12/FYI-260.pdf">New Mexico, which only has a 12% sales tax</a>.  Washington&#39;s tax is <a href="https://dor.wa.gov/about/statistics-reports/recreational-and-medical-cannabis-taxes">even higher at 37%</a>. </p>
<p>Because taxes were high, Colorado and Washington expected their latest marijuana industries to generate significant tax revenue. <a href="https://doi.org/10.7249/RR3138">These predictions</a> relied on surveys of illegal marijuana use and certain overestimated the usage of legal marijuana, which tends to be costlier than street drugs.</p>
<p>In 2014, then-Gov.  John Hickenlooper predicted it <a href="https://www.nytimes.com/2014/02/21/us/colorado-expects-to-reap-tax-bonanza-from-legal-marijuana-sales.html">Colorado would collect greater than $130 million</a> of marijuana tax revenue in the primary fiscal yr of sales.  Actual tax revenue was roughly $88 million. </p>
<p>Washington experienced an analogous deficit.  The State Office for Financial Management <a href="https://www.seattletimes.com/opinion/editorial-legalizing-marijuana-adds-revenue-reduces-law-enforcement-costs/">It was projected to gross $434 million</a> Tax revenue in fiscal yr 2015, greater than double realized revenue.</p>
<p>Additionally, each states&#39; tax revenues from alcohol and tobacco have been eroded by marijuana. <a href="https://doi.org/10.1086/712915">Research I published with economist Keaton Miller</a> found that folks were using marijuana as an alternative of alcohol and tobacco, resulting in a decline in income from these other sin goods.</p>
<p>According to our research, from July 2014 to June 2015, Washington skimmed 40%, or $56 million, from alcohol, wine and cigarette tax revenues.  Although each states collected more taxes overall than before legalization, the general increase shouldn&#8217;t be as large as politicians had predicted.</p>
<p>Apart from the undeniable fact that the expected tax revenues weren&#8217;t collected, <a href="https://www.forbes.com/sites/lcarrel/2023/06/12/cannabis-market-has-matured-to-point-of-declining-sales-growth/?sh=432b6a357155">States like California</a>, Oregon and Colorado experienced a slowdown and even a decline in marijuana sales and tax revenue.  One reason is because as <a href="https://www.forbes.com/sites/lcarrel/2023/06/12/cannabis-market-has-matured-to-point-of-declining-sales-growth/?sh=789aa1d17155">These markets are maturing</a>, the typical price of marijuana is falling.  Lower prices result in declining sales tax revenue.</p>
<p>For example, <a href="https://taxfoundation.org/research/all/state/cannabis-tax-revenue-reform">Marijuana prices in Colorado fell 60%</a> from 2014 to 2023. Colorado has lost tax revenue since then, and <a href="https://adai.uw.edu/wadata/marijuana.htm">Washington</a>The case shouldn&#8217;t be much different.</p>
<p><iframe id="szo60" class="tc-infographic-datawrapper" src="https://datawrapper.dwcdn.net/szo60/5/" height="400px" width="100%" style="border: none" frameborder="0"></iframe></p>
<h2>Taxing THC potency as an answer</h2>
<p>One tax system that seems secure from falling prices – so long as the identical amount of marijuana is sold – is a potency tax, which taxes marijuana based on its THC content.  So far only three states – <a href="https://taxfoundation.org/research/all/state/cannabis-tax-revenue-reform/">New York, Illinois and Connecticut</a> – Control THC potency. </p>
<p><a href="https://www.mpp.org/states/new-york/new-yorks-marijuana-regulation-and-taxation-act-(2021)/">New York taxes</a> Marijuana flowers at 0.5 cents per milligram;  concentrates at 0.8 cents per milligram of THC;  and food for 3 cents per milligram.  This is along with the 9% state sales tax and 4% local tax.</p>
<p>Based on potency <a href="https://taxfoundation.org/research/all/state/cannabis-tax-revenue-reform/">Control the trail to creation</a> a stable stream of tax revenue?  The answer is not any. </p>
<p>An effectiveness-based tax will only be effective if consumers have a strict preference for products with higher effectiveness and refuse to modify to products with lower effectiveness to avoid taxes.  But research I conducted with Keaton Miller, Benjamin Hansen and Caroline Weber found this <a href="https://doi.org/10.17310/ntj.2020.2.07">Consumers don&#39;t place much value on the potency of marijuana</a>.</p>
<p>Our research also shows that growers and processors can do that with ease <a href="https://doi.org/10.1186/s42238-024-00220-4">Reduce THC potency</a> of their products without excessive costs.  They achieve this by shortening the expansion time, changing the product mix or providing low-potency products as test samples.  As a result, potency taxes could have the unintended consequence of encouraging suppliers to sell low-THC products because they might likely still make similar profits. </p>
<p>So, is there a perfect tax structure that may generate a sturdy stream of marijuana tax revenue?  Not really.  Although tax policy has an impact available on the market, it may possibly do little to beat weak demand.  From this angle, a decline or stagnation in state tax revenues from marijuana is inevitable.  As the market matures and more states legalize marijuana, consumers can have more purchasing options and competition will intensify. </p>
<p>This implies that each the value of marijuana and the tax revenue related to its sales will likely proceed to say no in the longer term.</p>
</p></div>
<p><em>image credit : theconversation.com</em></p>
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