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	<title>rejects &#8211; USA NEWS LIVE</title>
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	<title>rejects &#8211; USA NEWS LIVE</title>
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		<title>23Andme special committee again rejects CEO Wojcicki&#039;s offer</title>
		<link>https://bloggingthree.soflytech.com/2025/03/23andme-special-committee-again-rejects-ceo-wojcickis-offer/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Tue, 04 Mar 2025 04:58:43 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[23andMe]]></category>
		<category><![CDATA[CEO]]></category>
		<category><![CDATA[committee]]></category>
		<category><![CDATA[offer]]></category>
		<category><![CDATA[rejects]]></category>
		<category><![CDATA[special]]></category>
		<category><![CDATA[Wojcicki39s]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=25607</guid>

					<description><![CDATA[23andmeThe special committee of the independent directors on Monday, Anne Wojcicki&#39;s proposal to take over the distributed gen testing company privately. Wojcicki submitted a proposal to the committee on Sunday during which he was in a position to purchase all of the outstanding shares of the corporate for 41 cents each A submission With the [&#8230;]]]></description>
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<p><span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-1">23andme<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>The special committee of the independent directors on Monday, Anne Wojcicki&#39;s proposal to take over the distributed gen testing company privately.</p>
<p>Wojcicki submitted a proposal to the committee on Sunday during which he was in a position to purchase all of the outstanding shares of the corporate for 41 cents each <a href="https://www.sec.gov/Archives/edgar/data/1804591/000114036125006615/xslSCHEDULE_13D_X01/primary_doc.xml" target="_blank">A submission</a> With the US Securities and Exchange Commission.</p>
<p>The stock fell by 33% to $ 1.47 on Monday, which declined to a decline of greater than 99% in comparison with its climax in 2021.</p>
<p>Wojcicki and New Mountain Capital submitted an earlier offer in February to take over the corporate privately for $ 2.53 per share. Days later New Mountain told Wojcicki that it was not concerned about participating in a possible acquisition and would hire discussions, the submission said.</p>
<p>23Andmes Special Committee said that Wojcicki&#39;s proposal was a decrease of 84% in comparison with the previous offer and is set not to maneuver forward, in order that it was impossible to advance, so <a href="https://investors.23andme.com/news-releases/news-release-details/23andme-special-committee-rejects-acquisition-proposal-ceo-anne" target="_blank">a publication</a> on Monday.</p>
<p>&#8220;In consultation with his financial and legal advisors, the special committee has checked Ms. Wojcicki&#39;s proposal and unanimously decided to reject the proposal,&#8221; said the administrators.</p>
<p>A representative of 23Andme rejected an announcement.</p>
<p>After a turbulent 2024, 23andme announced plans to explore in January <a href="https://investors.23andme.com/news-releases/news-release-details/23andme-special-committee-announces-exploration-strategic" target="_blank">Strategic alternatives</a>including a sale of the corporate or its assets, a restructuring or an organization combination. </p>
<p>Wojcicki previously submitted a proposal to take over the corporate privately in July for 40 cents per share, but it surely was <a href="https://investors.23andme.com/news-releases/news-release-details/23andme-special-committee-responds-ceos-take-private-proposal" target="_blank">rejected</a> Due to the special committee, partly since the members specified, there was no defined financing and at the moment didn&#8217;t provide a premium for the closing price.</p>
<p><strong>REGARD:</strong> The increase and fall of 23andme</p>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>San Mateo Court rejects the offer from Sheriff Corpus to dam special elections on March 4th</title>
		<link>https://bloggingthree.soflytech.com/2025/02/san-mateo-court-rejects-the-offer-from-sheriff-corpus-to-dam-special-elections-on-march-4th/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Thu, 27 Feb 2025 07:24:07 +0000</pubDate>
				<category><![CDATA[Politics]]></category>
		<category><![CDATA[4th]]></category>
		<category><![CDATA[block]]></category>
		<category><![CDATA[Corpus]]></category>
		<category><![CDATA[Court]]></category>
		<category><![CDATA[elections]]></category>
		<category><![CDATA[March]]></category>
		<category><![CDATA[Mateo]]></category>
		<category><![CDATA[offer]]></category>
		<category><![CDATA[rejects]]></category>
		<category><![CDATA[San]]></category>
		<category><![CDATA[sheriff]]></category>
		<category><![CDATA[special]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=25308</guid>

					<description><![CDATA[A judge of the district of San Mateo has the best way to come to a decision whether the supervisory authority must have the authority to remove the sheriff, released, released and a provisional judgment on Wednesday, February 26. Sheriff Christina Corpus, which is accused of corruption and misconduct within the work palle, stipulated a [&#8230;]]]></description>
										<content:encoded><![CDATA[<p><img decoding="async" src="https://www.mercurynews.com/wp-content/uploads/2024/11/SJM-L-SHERIFFCHAOS-1114-4.jpg?w=1400px&amp;strip=all" /></p>
<div>
<p>A judge of the district of San Mateo has the best way to come to a decision whether the supervisory authority must have the authority to remove the sheriff, released, released and a provisional judgment on Wednesday, February 26.</p>
<p>Sheriff Christina Corpus, which is accused of corruption and misconduct within the work palle, stipulated a petition on January 10 in front of the San Mateo Supreme Court to dam the Measure A from the ballot paper on March 4, and argued that the measure was illegal. However, the court decided that the alternative was as planned.</p>
<p>“The problem before the court is a narrower. The Court of Justice does not deal with the methodology, substance, merits or findings of the report, which judge Ladoris Cordell (RET) submitted to the board, and the court also does not make any statements or decisions about the allegations mentioned therein, ”wrote judge of San Mateo, Nicole Heale, in her preliminary decision. &#8220;Rather, this decision is only based on the question of whether the special elections for March 4, 2025 should be as planned.&#8221;</p>
<aside class="related left"></aside>
<p>Unless it&#8217;s controversial, the judgment becomes the ultimate order of the court.</p>
<p>Corpus didn&#8217;t answer the request of this news organization whether she was planning to query the choice.</p>
<p>The judge also said that he couldn&#8217;t choose the prejudices of Corpus by the board.</p>
<p>&#8220;After the&#8221; separation of the powers doctrine &#8220;, the courts cannot ask for the impulse or the motif for legislative measures,&#8221; said Healy in her judgment. &#8220;Whether the exercise of legislative powers, a board of directors acts carefully or unclear, is not a concern of the courts&#8221;, &#8220;</p>
<p>The district of the district of San Mateo, John Nibbelin, said he expected the decision.</p>
<p>&#8220;From the start we expected that the court agreed that the district was properly placed for measurement A for the ballot paper for the special elections on March 4, 2025,&#8221; said Nibbelin. “We look forward to this result. We believe that the decision of the sheriff not to question the preliminary judgment, reflect the strength of the legal position of the district and the care with which judge Healy prepared its decision. &#8220;</p>
<p>Corpus was increasingly checked whether misconduct, corruption and an inappropriate relationship with its former chief of staff Victor Aenlle. Despite the demands for her resignation of Sheriff&#39;s Captains, union members, six cities in San Mateo County and congress leaders, she refused to step down.</p>
<p>In response to this, the supervisory authority of the San Mateo district passed a Charter change from the district districts, which might give them the authority to temporarily remove a sheriff from office.</p>
<p>The verdict comes since the election is already good and the ballot papers are distributed to greater than 440,000 voters. On Wednesday at 4:30 p.m., the electoral office of the San Mateo district received 72,476 ballots, while 192 voters had sold their ballot papers in coordination centers. The last election day is March 4th.</p>
<p>According to election officers within the district, the special elections cost taxpayers a minimum of 3.8 million dollars.</p>
<p>If the measurement of a passport and the office of the sheriff becomes free, the supervisory board has several options: If you immediately appoint a brand new sheriff, provide public interviews before choosing a substitute or call a special alternative.</p>
<p>If the board doesn&#8217;t act inside 30 days, the election officer must call an election. A spokesman for the district previously said that the superiors had not yet decided whether or not they would appoint a successor or hold a special election.</p>
<p>If the measure fails, Corpus could proceed to confront the efforts to remove, including an investigation by the civil jury or a recall alternative. The supervisory authorities previously discussed these options after they censored them and demanded their resignation in November 2024.</p>
<p>Corpus has biased Cordell&#39;s examination and rejected politically motivated. She didn&#8217;t answer what she desires to do when measuring a passport.</p>
<p>There is not any provision within the district chart or within the state election code that forestalls corpus from running again for sheriff.</p>
</p></div>
<p><em>image credit : www.mercurynews.com</em></p>
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		<title>Rafael -devers rejects the talk of switching to DH for Red Sox</title>
		<link>https://bloggingthree.soflytech.com/2025/02/rafael-devers-rejects-the-talk-of-switching-to-dh-for-red-sox/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Tue, 18 Feb 2025 01:18:57 +0000</pubDate>
				<category><![CDATA[Sports]]></category>
		<category><![CDATA[Devers]]></category>
		<category><![CDATA[Rafael]]></category>
		<category><![CDATA[Red]]></category>
		<category><![CDATA[rejects]]></category>
		<category><![CDATA[Sox]]></category>
		<category><![CDATA[Switching]]></category>
		<category><![CDATA[talk]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=24755</guid>

					<description><![CDATA[Red Sox Alex Bregman opened his options this weekend when he was asked about his preference where he would love to play within the Red Sox -infield this season. &#8220;I just want to play wherever the team helps to win,&#8221; Bregman told reporters on Sunday. “I will leave this decision to AC [Alex Cora]And I [&#8230;]]]></description>
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<p>								Red Sox<br />
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<p>Alex Bregman opened his options this weekend when he was asked about his preference where he would love to play within the Red Sox -infield this season.</p>
<p>&#8220;I just want to play wherever the team helps to win,&#8221; Bregman told reporters on Sunday. “I will leave this decision to AC [Alex Cora]And I will just do what he tells me and try to be there every day, work hard and get ready. &#8220;</p>
<p>Although Alex Cora signaled at the beginning of this winter that Bregman could make a simple change to the second basis (and only nine games around the second).</p>
<p>Although this change to the third Rafael -Devers would force either to switch to ie or the first basis, Bregman would help to consolidate Boston&#39;s bad infield defense -especially after winning a gold glove at the position with Houston in 2024 . </p>
<p>The push from devers to DH could only concentrate a win-win situation for all parties only on beating, support a defensive lack of the process and at the same time restrict part of the wear that hindered the 28-year-old. Star in the last seasons.</p>
<p>But Devers spoke on Monday in Fort Myers with reporters to remain in third place after Bregman&#39;s arrival. </p>
<p>&#8220;The third basis is my position,&#8221; Devers told reporters. &#8220;It is what I played. I don&#39;t know what your plans are. I know we had a conversation. I made it clear what my wishes were and whatever happens from here, I don&#39;t know. &#8220;</p>
<p>When asked what he would say if the team insisted that he was playing to play to take Bregman, Devers replied: &#8220;No.&#8221; </p>
<p>He was then asked to clarify Daveeson Perez by Red Sox employee and translator.</p>
<p>&#8220;As I said, it is my position and I will not only change out of a mood.&#8221;<a target="_blank" href="https://www.nytimes.com/athletic/6142254/2025/02/17/red-sox-rafael-devers-designated-hitter-alex-bregman/" rel="noreferrer noopener"> Devers said how transcribed by </a><a target="_blank" href="https://www.nytimes.com/athletic/6142254/2025/02/17/red-sox-rafael-devers-designated-hitter-alex-bregman/" rel="noreferrer noopener">Jen McCafrey.</a>  </p>
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"></figure>
<p>Devers admitted that he had held a conversation with Alex Cora and the Chief Baseball Officer Craig Wroclow, shortly before the signing of the BREGMAN was officially done due to alternating positions.  </p>
<p>&#8220;You asked me the question of how I feel about you, and yes, I gave you the answer that I just gave: No,&#8221; said Devers and later added that it was a &#8220;surprise&#8221;. &#8220;I am someone I believe in the word of people, and I take it to heart and yes, it was very surprising that they would suggest it.&#8221;</p>
<p>Cora was asked whether there were potential promises or guarantees that were granted to the team after signing a 10-year contract extension of $ 313.5 million with the team on the third basis in January 2023. </p>
<p>&#8220;Different people here. There is another leader here. Chaim is now in St. Louis, ”said Cora regarding Chaim Bloom, who from October 2019 to September 2023 acted as Chief Baseball Officer from Red Sox. </p>
<p>Despite the change of leadership from Bloom to Wroclaw, Devers admitted that he had not expected to alter the positions <a target="_blank" href="https://www.spotrac.com/mlb/player/_/id/18493/rafael-devers" rel="noreferrer noopener">At nine years left of his current contract. </a></p>
<p>&#8220;I don&#39;t know what the change caused,&#8221; said Devers. “But I do know that I even have worked very hard on my defense over time. I even have the sensation that I had a very good 12 months last 12 months. You know, I even have quite a bit more to offer. But I definitely have the sensation that it was really good last 12 months and I hope to proceed doing it. &#8220;</p>
<p>Despite Devers&#39; comments, his defense in the hot corner was still a problem &#8211; since he has led the AL in third place in every single season since 2018.</p>
<p>Although his 12 mistakes last year since his debut in 2017, the devers still released one <a target="_blank" href="https://baseballsavant.mlb.com/leaderboard/outs_above_average?type=Fielder&#038;startYear=2024&#038;endYear=2024&#038;split=yes&#038;team=&#038;range=year&#038;min=q&#038;pos=5&#038;roles=&#038;viz=hide&#038;_gl=1*1ct5rsh*_gcl_au*MTM3NDU1OTg3LjE3MzgwMzMwNTk.*_ga*MTcwNjYzMjA2LjE3MTgxNzkxOTQ.*_ga_N8YFCZLYSZ*MTczOTgzMjMwMS4xMzEuMC4xNzM5ODMyMzAxLjYwLjAuNTQ2OTUwNjMw" rel="noreferrer noopener">Negative 6-outs above average</a> Last season. Bregman ended the last season with Houston with plus-6-outs. </p>
<p>Despite Dever&#39;s open comments, Cora emphasized that all the installation decisions are far from being set in stone &#8211; especially with Boston, who still wants to see whether Kristian Campbell deserve the top prospect Kristian Campbell in the second basis outside the camp can.</p>
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"></figure>
<p>&#8220;It is currently too early to say that Raffy will likely be a DH or the third basis will play, or that Alex will likely be a second Baseman or the third basis will play,&#8221; said Cora. “There is competition here and I think flexibility and versatility are enormous for us. </p>
<p>&#8220;We have some talented boys. We will take the very best roster to Texas [for Opening Day]. &#8220;&#8221;</p>
<p>Cora added that he would proceed to talk to devers if they struggle to search out out where he most closely fits in Boston&#39;s revised defense in 2025. </p>
<p>&#8220;I will talk to Raffy, we will continue to work and we will make decisions about what we need to win the department,&#8221; said Cora. “I and Raffy have an awesome relationship. This is something through which I will definitely set: &#39;Hey man, that&#39;s the baseball page of it. We are still Raffy and Alex. &#39; </p>
<p>“I&#39;ve been with this child since November 2017. It is a component of the business. We will proceed to work. Decisions are made on the idea of the duty plan construction. That is the truth of it and we&#8217;ll proceed to speak. &#8220;</p>
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		<img decoding="async" class="" src="https://www.boston.com/wp-content/uploads/2023/05/Headshot_Conor-645c0406ed6cb-scaled.jpg" alt="Profile picture for Conor Ryan">	</div>
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<p>Conor Ryan is an worker who reports the Bruins, Celtics, Patriots and Red Sox for Boston.com, a job that he has been holding since 2023.</p>
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		<title>Supreme Court rejects Trump bid to delay hush money sentencing</title>
		<link>https://bloggingthree.soflytech.com/2025/01/supreme-court-rejects-trump-bid-to-delay-hush-money-sentencing/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Fri, 10 Jan 2025 09:55:01 +0000</pubDate>
				<category><![CDATA[Politics]]></category>
		<category><![CDATA[bid]]></category>
		<category><![CDATA[Court]]></category>
		<category><![CDATA[delay]]></category>
		<category><![CDATA[hush]]></category>
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		<category><![CDATA[Trump]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=22413</guid>

					<description><![CDATA[The USA Supreme Court On Thursday, he narrowly rejected a request from President-elect Donald Trump to drop proceedings in his hush money case in New York, clearing the best way for his sentencing Friday morning. Two conservatives — Chief Justice John Roberts and Justice Amy Coney Barrett — joined liberal Justices Sonia Sotomayor, Elena Kagan [&#8230;]]]></description>
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<p>The USA <a href="https://www.supremecourt.gov/search.aspx?filename=/docket/docketfiles/html/public/24a666.html" target="_blank">Supreme Court</a> On Thursday, he narrowly rejected a request from President-elect Donald Trump to drop proceedings in his hush money case in New York, clearing the best way for his sentencing Friday morning.</p>
<p>Two conservatives — Chief Justice John Roberts and Justice Amy Coney Barrett — joined liberal Justices Sonia Sotomayor, Elena Kagan and Ketanji Brown Jackson <a href="https://www.supremecourt.gov/search.aspx?filename=/docket/docketfiles/html/public/24a666.html" target="_blank">the 5-4 decision</a> They rejected Trump&#39;s offer of an emergency stay.</p>
<p>The other conservatives, Justices Samuel Alito, Clarence Thomas, Neil Gorsuch and Brett Kavanaugh, granted the president-elect&#39;s request, the court said in a transient order.</p>
<p>The majority concluded that convicting Trump would impose a &#8220;relatively insignificant&#8221; burden on his presidential responsibilities because he can be expected to receive a sentence that might not lead to actual punishment, the order said.</p>
<p>The five justices were also not swayed by Trump&#39;s arguments concerning the use of certain evidence during his criminal trial.</p>
<p>These alleged violations of evidence “can be resolved in the ordinary appeal process,” the bulk decided, in response to the choice. </p>
<p>In arguing against the stay of the sentence, the Manhattan district attorney&#39;s office had argued that the Supreme Court had no jurisdiction over the case because Trump had not yet exhausted his options to appeal his conviction in state court.</p>
<p>That of the Supreme Court<a href="https://www.supremecourt.gov/search.aspx?filename=/docket/docketfiles/html/public/24a666.html" target="_blank"> Decision</a> got here hours after New York State&#39;s highest appeals court <a href="https://www.nbcnews.com/politics/donald-trump/trump-hush-money-sentencing-supreme-court-delay-rcna186970" target="_blank">refused to delay</a> the condemnation.</p>
<p>Trump said: “I respect the opinion of the court.”</p>
<p>“I think it was actually a very good opinion for us because you saw what they said, but they invited the call,” Trump said at a roundtable event with 22 Republican governors.</p>
<p>  “We will appeal [the conviction] At least psychologically,” Trump said. “Because, honestly, it’s a shame.” </p>
<p>Trump was convicted in Manhattan state court last May of 34 counts of falsifying business records in reference to a $130,000 hush-money payment to porn star Stormy Daniels before the 2016 presidential election.</p>
<p>Trump&#39;s lawyers argued in a filing with the Supreme Court on Wednesday that any further proceedings needs to be placed on hold while the president-elect appeals the ruling.</p>
<p>The case needs to be stayed to “prevent grave injustice and harm to the institution of the presidency and the work of the federal government,” they wrote within the 51-page filing.</p>
<p>They argued that as president-elect, Trump was immune from criminal prosecution. New York Court Judge Juan Merchan rejected that claim.</p>
<p>The lawyers also argued that the Manhattan district attorney&#39;s office violated Trump&#39;s immunity privileges by utilizing evidence of his presidential actions through the hush money trial.</p>
<p>The Supreme Court significantly expanded the scope of presidential immunity last July when it ruled that former presidents enjoy “presumptive immunity” for all official acts.</p>
<p>Manhattan District Attorney Alvin Bragg argued in a filing Thursday that there&#8217;s &#8220;no basis&#8221; for the Supreme Court to intervene within the case.</p>
<p>The president-elect&#39;s group of lawyers includes several who&#8217;ve been chosen for top positions in the subsequent administration&#39;s Justice Department.</p>
<p>A <a href="https://www.nbcnews.com/politics/donald-trump/trumps-lawyers-ask-new-york-appeals-court-halt-friday-hush-money-sente-rcna186586" target="_blank">New York Court of Appeals</a> and the <a href="https://www.nbcnews.com/politics/donald-trump/trump-hush-money-sentencing-supreme-court-delay-rcna186970" target="_blank">State Supreme Court</a> Both had rejected Trump&#39;s try to interrupt his sentencing hearing on Friday morning.</p>
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<p>Merchan had already postponed Trump&#39;s sentencing several times, each before and after the November 5 presidential election.</p>
<p>The judge is anticipated to impose an “unconditional discharge,” meaning Trump will receive no prison time, probation, fines or other conditions.</p>
<p>On Wednesday afternoon <a href="https://abcnews.go.com/US/trump-speaks-justice-alito-amid-push-halt-criminal/story?id=117386419" target="_blank">ABC News</a> It was first reported that Trump spoke with conservative Supreme Court Justice Samuel Alito a day before the president-elect asked the court for an instantaneous stay.</p>
<p><a href="https://www.nbcnews.com/politics/supreme-court/justice-alito-says-was-no-discussion-trumps-pending-case-two-spoke-rcna186907" target="_blank">Alito confirmed</a> that the phone call took place on Tuesday afternoon, but said in an announcement that the hush money case was not discussed.</p>
<p>“We have not discussed the emergency motion that he filed today, and in fact, at the time of our conversation, I was not even aware that such a motion would be filed,” Alito said.</p>
<p>— </p>
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		<title>San Mateo County rejects sheriff&#039;s $10 million demand</title>
		<link>https://bloggingthree.soflytech.com/2025/01/san-mateo-county-rejects-sheriffs-10-million-demand/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Thu, 09 Jan 2025 23:52:53 +0000</pubDate>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=22377</guid>

					<description><![CDATA[San Mateo County defended itself against a $10 million government lawsuit filed last month by embattled Sheriff Christina Corpus. She claims the county&#39;s investigation into alleged misconduct and corruption by her administration stems from harassment and discrimination. &#8220;The allegations in Corpus&#39; claim &#8211; that she has been discriminated against, harassed and defamed, particularly because she [&#8230;]]]></description>
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<p>San Mateo County defended itself against a $10 million government lawsuit filed last month by embattled Sheriff Christina Corpus. She claims the county&#39;s investigation into alleged misconduct and corruption by her administration stems from harassment and discrimination.</p>
<p>&#8220;The allegations in Corpus&#39; claim &#8211; that she has been discriminated against, harassed and defamed, particularly because she is both a woman and a Latina person &#8211; are completely baseless and distract from the issues that give rise to the current circumstances,&#8221; the said county in a press release released this week.</p>
<p>Filing a state lawsuit is a required step before a lawsuit can begin.</p>
<p>The lawsuit follows the November 2024 release of an independent audit by retired Judge LaDoris Cordell detailing allegations of misconduct, corruption and workplace bullying involving Corpus and her former chief of staff Victor Aenlle on the San Mateo County Sheriff&#39;s Office were described.</p>
<p>“The government’s lawsuit, which contains false and misspelled names – including those of the sheriff himself and Supervisor Noelia Corzo – is largely devoid of alleged facts supporting its conclusions and egregiously accuses retired Judge LaDoris Cordell of complicity to be what the lawsuit calls an &#39;evil scheme,&#39;&#8221; the county said.</p>
<p>Brad Gage, a lawyer for Corpus, claimed that the investigation led by Cordell was at risk and pointed to the former judge&#39;s financial compensation as a potential conflict of interest.</p>
<p>“Generally, investigators are paid by the municipal employer – in this case, the county,” Gage previously told this news organization. “If their results are not in the employer’s favor, they risk losing future business. It’s a lucrative system for those who conduct these investigations.”</p>
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<p>The district rejected these allegations on the grounds that paying for the investigation was common practice when hiring external auditors.</p>
<p>“With respect to the cost of the investigation, Cordell was contracted at $750 per hour, and the investigation and associated report cost approximately $200,000 to complete,” the county said, publicly citing Cordell for the first time amount paid is known.</p>
<p>The county said the cost reflects the extensive work that was done, including interviews with 40 current and former employees, and the time it took to adjudicate numerous complaints.</p>
<p>“This is consistent with the expense of a complex and sensitive investigation of this nature, as well as the level of experience, expertise and unique qualifications that Cordell brought to the matter,” it said.</p>
<p>Another issue raised in the lawsuit concerns an alleged missing 29 pages from Cordell&#39;s interview with Aenlle, according to Gage.</p>
<p>The district denied that the omission of pages from Aenlle&#39;s interview was &#8220;disgraceful.&#8221; .</p>
<p>“Twenty-nine pages of the transcript were not included in the exhibit because they were not cited by Cordell nor were they relevant to the report,” the county statement said. “There was nothing wrong with these pages not being included, but given the level of interest, they are now available on the county website.”</p>
<p>Gage disagreed, saying the missing pages were essential to the investigation.</p>
<p>“It shouldn’t have been held back and hidden,” Gage said in a telephone interview Thursday. &#8220;Maybe it wasn&#39;t cited by Judge Cordell, but it surely must have been, because those are the pages that show lots of the conclusions are usually not supported.&#8221;</p>
<p>This March, San Mateo County voters will decide whether to give the Board of Supervisors the authority to remove Corpus from office, which would remain in effect until the end of Corpus&#39; term in 2028. County election officials estimate the cost of the election to be more than $3.8 million.</p>
<p>The San Mateo County Board of Supervisors, two sheriff&#39;s deputy unions, sheriff&#39;s department heads, several congressional and local politicians, and the city of San Carlos have all passed votes of no confidence in Corpus&#39; leadership. She also faces a separate investigation into alleged campaign finance violations.</p>
<p>Despite mounting pressure, Corpus refused to resign or allow recall efforts.</p>
<p>“The defendants (San Mateo County) have now used the false investigation to seek an unprecedented recall – one that ends when Sheriff Corpus’ term expires – in an attempt to fire her based on false allegations,” says the lawsuit. “It’s time to fight back and bring the truth to light. This government claim is just part of that process.”</p>
<p><iframe src="https://embed.bloom.li/article/map?zoom=far&#038;post_key=KKico7D2xpxSPYhHwBi2" title="Story map" style="display:block;border:none;visibility:visible;width:100% !essential;height:300px;"></iframe></p>
<p>Originally published: <time datetime="2025-01-09 15:42:39">January 9, 2025 at 3:42 pm PST</time></p>
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<p><em>image credit : www.mercurynews.com</em></p>
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		<title>Judge rejects Trump&#039;s request to defer sentence</title>
		<link>https://bloggingthree.soflytech.com/2025/01/judge-rejects-trumps-request-to-defer-sentence/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Tue, 07 Jan 2025 01:35:12 +0000</pubDate>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=22194</guid>

					<description><![CDATA[A latest York The judge on Monday rejected a request from President-elect Donald Trump to postpone Friday&#39;s scheduled sentencing in his New York hush money case. The ruling means Trump could have to get an appeals court to dam his conviction if he fails to look on the trial 10 days before he&#8217;s scheduled to [&#8230;]]]></description>
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<p>A <a href="https://www.nycourts.gov/LegacyPDFS/press/pdfs/1-6-25-Dec-on-Motion-for-Stay.pdf" target="_blank">latest York</a> The judge on Monday rejected a request from President-elect Donald Trump to postpone Friday&#39;s scheduled sentencing in his New York hush money case.</p>
<p>The ruling means Trump could have to get an appeals court to dam his conviction if he fails to look on the trial 10 days before he&#8217;s scheduled to be sworn in as president for a second non-consecutive term within the White House.</p>
<p>Trump&#39;s lawyers had argued earlier Monday to Manhattan Supreme Court Justice Juan Merchan that the sentencing needs to be mechanically stayed pending an appeal of recent decisions he made within the case.</p>
<p>Merchan rejected this argument.</p>
<p>“This court has reviewed defendant&#39;s arguments in support of his motion and concludes that they are largely a repetition of arguments he has made numerous times in the past,” Merchan wrote in a call.</p>
<p>“Furthermore, this court finds that the authorities relied upon by defendant in the present motion are largely factually distinguishable from the actual record or are not legally applicable,” the judge wrote.</p>
<p>The Manhattan district attorney&#39;s office had previously asked Merchan to disclaim Trump&#39;s request to delay his sentencing pending an appeal.</p>
<p>The prosecutor&#39;s office said there was a &#8220;strong public interest in expeditious prosecution and the finality of the criminal proceedings &#8211; interests that are particularly salient here in light of the jury&#39;s guilty verdict.&#8221;</p>
<p>Trump was convicted in May of 34 counts of falsifying business records related to a hush-money payment to porn star Stormy Daniels in 2016, just before that 12 months&#39;s presidential election.</p>
<p>Merchan said last week that he was not inclined to sentence Trump to prison within the case and in addition suggested he would impose a sentence that didn&#8217;t include probation or a advantageous.</p>
<p>The same day, Merchan rejected arguments that he should dismiss the case in light of a U.S. Supreme Court ruling that presidents enjoy presumptive immunity from prosecution for official acts while within the White House and due to Constitution&#39;s Supremacy Clause.</p>
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<p>The prosecution&#39;s motion on Monday states that Merchan &#8220;has already explained this [his] Because he intends to impose the lowest sentence permitted by law, Trump will not suffer any harm from closing the case through conviction that would allow him to appeal his conviction.</p>
<p>In a statement Monday, Trump spokesman Steven Cheung said: &#8220;Today, President Trump&#39;s legal team took steps to stop the wrongful conviction as a part of the Manhattan District Attorney&#39;s witch hunt.&#8221;</p>
<p>“The Supreme Court’s historic decision on immunity, the New York State Constitution and other established precedents demand that this baseless hoax be immediately rejected,” Cheung said.</p>
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		<title>Court Rejects Boeing Settlement in 737 Max Crashes, Citing DEI Concerns</title>
		<link>https://bloggingthree.soflytech.com/2024/12/court-rejects-boeing-settlement-in-737-max-crashes-citing-dei-concerns/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Thu, 05 Dec 2024 23:13:19 +0000</pubDate>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=20376</guid>

					<description><![CDATA[A federal judge rejected that on Thursday BoeingThe manufacturer&#39;s settlement is said to a criminal fraud charge related to fatal crashes involving the manufacturer&#39;s 737 Max aircraft. U.S. District Judge Reed O&#39;Connor of the U.S. District Court for the Northern District of Texas expressed concerns in his ruling that the choice process for a government-appointed [&#8230;]]]></description>
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<p>A federal judge rejected that on Thursday <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-1">Boeing<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>The manufacturer&#39;s settlement is said to a criminal fraud charge related to fatal crashes involving the manufacturer&#39;s 737 Max aircraft.</p>
<p>U.S. District Judge Reed O&#39;Connor of the U.S. District Court for the Northern District of Texas expressed concerns in his ruling that the choice process for a government-appointed observer, a condition of the plea deal, could be compromised by diversity, equity and inclusion policies.</p>
<p>He wrote: “In view of the foregoing, the Court is not satisfied that the Government will not select an observer without racial considerations and therefore will not act in a non-discriminatory manner. In a case of this magnitude, this is of the utmost interest. &#8220;It is reasonable for the public to believe that this monitor selection is based solely on competence.&#8221;</p>
<p>In October, O&#39;Connor directed Boeing and the Justice Department to provide details on DEI policies that could affect the monitor&#39;s selection.</p>
<p>According to a court document filed Thursday, the court gave Boeing and the Justice Department 30 days to decide how to proceed.</p>
<p>In July, Boeing agreed to plead guilty to a criminal charge of conspiring to defraud the U.S. government by deceiving regulators about the installation of a flight control system on the Max that was later involved in the two crashes &#8211; a Lion Air flight in October 2018 &#8211; and an Ethiopian Airlines flight in March 2019. All 346 people on the flights were killed.</p>
<p>Boeing and the Justice Department did not immediately comment.</p>
<p>Victims&#39; family members objected to a government-appointed monitor as a condition of the agreement, which they called a &#8220;sweetheart deal,&#8221; and sought to have more influence in the monitor&#39;s selection.</p>
<p>Erin Applebaum, an attorney representing one of the victims&#39; family members, welcomed the deal. “We expect a significant renegotiation of the plea deal that includes terms that are truly commensurate with the seriousness of Boeing’s crimes,” Applebaum said in a press release. “It’s time for the DOJ to end its lenient treatment of Boeing and demand real accountability.”</p>
<p>The deal was intended to permit Boeing to avoid a lawsuit because it tried to place the corporate back on solid footing after a door panel on a 737 Max 9 exploded in mid-air on Jan. 5 during an Alaska Airlines flight.</p>
<p>The recent settlement agreement got here after the Justice Department said in May that Boeing had violated a previous settlement agreement that was set to run out days after the door panel incident.</p>
<p>O&#39;Connor said in his decision Thursday that it was &#8220;not clear what Boeing did to violate the Deferred Prosecution Agreement.&#8221;</p>
<p>Under the brand new plea agreement, Boeing would face a nice of as much as $487.2 million. However, the Justice Department really useful that the court credit Boeing with half of the quantity paid under a previous agreement, leading to a $243.6 million nice.</p>
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		<title>Worcester rejects a petition that may have required immigrants running for office to present their papers</title>
		<link>https://bloggingthree.soflytech.com/2024/10/worcester-rejects-a-petition-that-may-have-required-immigrants-running-for-office-to-present-their-papers/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Sat, 19 Oct 2024 18:19:29 +0000</pubDate>
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					<description><![CDATA[Local News A petition requiring candidates for office in Worcester to supply naturalization papers as proof of citizenship was met with strong opposition at a Worcester City Council meeting Tuesday night. “This was strategically placed right before an election,” Worcester Mayor and City Councilor Joseph Petty said on the meeting. “It could have been placed [&#8230;]]]></description>
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<p>A petition requiring candidates for office in Worcester to supply naturalization papers as proof of citizenship was met with strong opposition at a Worcester City Council meeting Tuesday night.</p>
<p>“This was strategically placed right before an election,” Worcester Mayor and City Councilor Joseph Petty said on the meeting. “It could have been placed a year ago. It could have been several months ahead. It seems to have been planted tonight, so we can all talk about it.”</p>
<p>He continued: &#8220;Unfortunately sometimes people believe this rhetoric, but I won&#39;t allow it.&#8221;</p>
<p>Worcester City Council voted unanimously to table the petition, stopping it from moving forward.</p>
<p>The <a href="https://www.sec.state.ma.us/divisions/elections/download/getting-on-the-ballot/How-to-Run-for-Office.pdf">Law</a> already states that to run for office you need to be a registered voter, which requires citizenship. However, that&#8217;s <a href="https://www6.worcesterma.gov/weblink/0/doc/548540/Page1.aspx">petition</a> The motion, submitted by the Worcester Republican City Committee, requested additional documentation.</p>
<p>The petition states that candidates who weren&#8217;t born within the United States but have turn out to be naturalized American residents must &#8220;present under oath to the city clerk naturalization papers or other legal documents as proof of citizenship&#8221; before they might be approved to run for office .</p>
<p>In its submitted justification, the committee stated: “Citizens of other countries should not impose tax, zoning, housing, infrastructure and education policies on American citizens.”</p>
<p>The committee also explained that the petition was submitted to acquire “FREE” press and promoting for the group.  </p>
<p>“As you know, we live in a country based on the rule of law,” Mary Ann Carroll, chair of the Worcester City Republican Committee, said on the meeting. “I am here tonight to ask for your help in ensuring that the laws of our country, our state and our city are followed regarding candidates for election in the City of Worcester.” </p>
<p>Carroll added, “This is not a cumbersome additional step” to require naturalized residents to supply additional documents to prove their citizenship. “It only excludes people who are excluded by law.” </p>
<p>Carroll was within the minority when he spoke in favor of the petition. In the nearly two-hour public speech in the course of the meeting, only three out of 54 people spoke in favor of it. </p>
<p>Most said the petition was stuffed with bigotry, xenophobia and scaremongering.</p>
<p>“This is a trick,” said Fred Taylor, president of the local NAACP chapter, during a virtual call to the meeting. “A ploy to sow division, a ploy to incite hatred, a ploy to deter future candidates. “Hate has no place in the city of Worcester.” </p>
<p>Two city councilors are naturalized residents: District 5 member Etel Haxhiaj from Albania and member Thu Nguyen from Vietnam. </p>
<p>Haxhiaj said she was targeted online by individuals who demanded she hand over her naturalization papers and photos of her obtaining American citizenship. </p>
<p>“I am here to stay and I have nothing to prove to those of you who want to divide us,” Haxhiaj said on the meeting. </p>
<p>She continued: “Extremist ideas will not go unchallenged. It’s time for you to retire them and throw them in the trash where they belong.” </p>
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<p>Beth Treffeisen is a general task reporter at Boston.com, specializing in local news, crime and business within the New England region.</p>
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		<title>Court rejects immunity for police officer who shot George Floyd protesters</title>
		<link>https://bloggingthree.soflytech.com/2024/09/court-rejects-immunity-for-police-officer-who-shot-george-floyd-protesters/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Thu, 05 Sep 2024 00:47:09 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[Court]]></category>
		<category><![CDATA[Floyd]]></category>
		<category><![CDATA[George]]></category>
		<category><![CDATA[immunity]]></category>
		<category><![CDATA[officer]]></category>
		<category><![CDATA[police]]></category>
		<category><![CDATA[protesters]]></category>
		<category><![CDATA[rejects]]></category>
		<category><![CDATA[shot]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=13871</guid>

					<description><![CDATA[A federal appeals court has denied qualified immunity to a San Jose police officer who shot an activist within the groin with a bullet during downtown George Floyd protests 4 years ago, allowing a trial on charges of excessive force to proceed. The Ninth Circuit Court of Appeals wrote in an opinion released Wednesday that [&#8230;]]]></description>
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<p>A federal appeals court has denied qualified immunity to a San Jose police officer who shot an activist within the groin with a bullet during downtown George Floyd protests 4 years ago, allowing a trial on charges of excessive force to proceed.</p>
<p>The Ninth Circuit Court of Appeals wrote in an opinion released Wednesday that a jury needs to be allowed to determine whether Derrick Sanderlin&#39;s First and Fourth Amendment rights were violated when Officer Michael Panighetti hit him with a 40mm foam baton on May 29, 2020, as he stood together with his hands raised between a police line and protesters near City Hall while holding an indication.</p>
<p>Last yr, the town of San Jose appealed a district court&#39;s denial of Panighetti&#39;s immunity, arguing that the shooting was not retaliatory, was not intended to stifle Sanderlin&#39;s free speech, and was not an excessive use of force. A 3-judge panel of the ninth District Court affirmed the lower court&#39;s decision.</p>
<p>&#8220;It was an unreasonable delay and I&#39;m glad we&#39;re back,&#8221; said plaintiff&#39;s attorney Sarah Marinho. &#8220;My clients obviously want justice for the harm they suffered, but they also collectively want to ensure that something like this never happens to the community again. We hope the City of San Jose gets the message.&#8221;</p>
<p>The San Jose City Attorney&#39;s Office declined to comment on the decision, citing the reference to ongoing legal proceedings.</p>
<p>In a related memorandum, the panel reversed a district court decision and located that Captain Jason Dwyer, the operations commander on the primary day of the protests, was entitled to qualified immunity and needs to be barred from the lawsuit. Qualified immunity is a legal protection that protects government employees from lawsuits for work-related actions absent clear violations of constitutional or statutory rights.</p>
<p>The court ruled that Dwyer&#39;s authorization of police to make use of rubber and foam bullets and tear gas for crowd control &#8211; an authorization the town has since limited within the wake of the protests &#8211; didn&#8217;t violate any clearly established legal text, and due to this fact he&#8217;s exempt from qualified immunity.</p>
<p>In the memorandum, the court also affirmed the denial of immunity to a few officers &#8211; Lee Tassio, Jonathan Marshall and Juan Avila &#8211; in reference to claims made by Vera Clanton, one other defendant in the identical lawsuit. Clanton was documenting the protests as a legal observer when, in keeping with the plaintiffs, she was grabbed, thrown to the bottom and handcuffed.</p>
<p>In their decision against Panighetti, Justices Richard Paez, Jacqueline Nguyen and Michelle Friedland ruled that the query of whether the officer retaliated against Sanderlin&#39;s free speech rights should be decided by a jury. They also rejected the town&#39;s argument that Panighetti was not attempting to restrain or arrest Sanderlin when he fired the froth bullet but was attempting to get him to depart.</p>
<aside class="related left"></aside>
<p>&#8220;The method of force used by Panighetti is, by its nature, intended to incapacitate the victim, making it difficult for him to walk away freely. A reasonable trier of fact, examining this evidence, might conclude that by firing a 40mm projectile at Sanderlin&#39;s groin, Panighetti objectively expressed an intent to restrain Sanderlin,&#8221; wrote Nguyen, who wrote the panel&#39;s opinion.</p>
<p>In his opinion, Nguyen found that the panel viewed the facts in a lightweight most favorable to the plaintiff, which is required on the summary judgment stage when a case is being examined for its ability to face trial.</p>
<p>As a results of Wednesday&#39;s ruling, the excessive-force claims of 5 other co-plaintiffs, which had been given the green light for a trial in March 2023 &#8211; but were postponed pending appeal &#8211; will even be heard further. These plaintiffs all claimed within the lawsuit that they were injured by rubber bullets, tear gas or mistreatment by law enforcement officials during peaceful protests.</p>
<p>Another lawsuit involving multiple plaintiffs from people injured throughout the protest, including a bystander who lost his eye to a police projectile, was settled by the town last yr for $3.3 million. Marinho said she desired to move her clients&#39; lawsuit toward a resolution quickly.</p>
<p>&#8220;I have high hopes that it will not take another year,&#8221; she said. &#8220;Today&#39;s decision takes us further in this regard.&#8221;</p>
<p>Originally published: <time datetime="2024-09-04 16:06:03">September 4, 2024 at 16:06</time></p>
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<p><em>image credit : www.mercurynews.com</em></p>
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		<title>FDA rejects MDMA-assisted therapy to treat PTSD – a drug researcher explains the challenges psychedelics face</title>
		<link>https://bloggingthree.soflytech.com/2024/08/fda-rejects-mdma-assisted-therapy-to-treat-ptsd-a-drug-researcher-explains-the-challenges-psychedelics-face/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Tue, 13 Aug 2024 02:31:27 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[challenges]]></category>
		<category><![CDATA[drug]]></category>
		<category><![CDATA[explains]]></category>
		<category><![CDATA[face]]></category>
		<category><![CDATA[FDA]]></category>
		<category><![CDATA[MDMAassisted]]></category>
		<category><![CDATA[psychedelics]]></category>
		<category><![CDATA[PTSD]]></category>
		<category><![CDATA[rejects]]></category>
		<category><![CDATA[researcher]]></category>
		<category><![CDATA[therapy]]></category>
		<category><![CDATA[treat]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=11756</guid>

					<description><![CDATA[Drugmaker Lykos Therapeutics announced on August 9, 2024 that the Food and Drug Administration refused to grant the corporate’s request for using MDMA-assisted therapy within the treatment of Posttraumatic stress disorderThis is the primary decision of its kind on an application for marketing authorization for a psychedelic drug. Many investors and researchers were Predicting a [&#8230;]]]></description>
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<p><em>Drugmaker Lykos Therapeutics announced on August 9, 2024 that the Food and Drug Administration <a href="https://news.lykospbc.com/2024-08-09-Lykos-Therapeutics-Announces-Complete-Response-Letter-for-Midomafetamine-Capsules-for-PTSD">refused to grant the corporate’s request</a> for using MDMA-assisted therapy within the treatment of <a href="https://www.nimh.nih.gov/health/topics/post-traumatic-stress-disorder-ptsd#">Posttraumatic stress disorder</a>This is the primary decision of its kind on an application for marketing authorization for a psychedelic drug.</em></p>
<p><em>Many investors and researchers were <a href="https://apnews.com/article/psychedelic-drugs-mushrooms-startups-psilocybin-fda-e3f629f817781b096d72535e022d8b2f">Predicting a Psychedelic Boom</a>MDMA is just the primary of a variety of psychedelics within the drug development pipeline.</em> </p>
<p><em>The FDA’s decision has <a href="https://www.npr.org/sections/shots-health-news/2024/08/09/nx-s1-5068634/mdma-therapy-fda-decision-ptsd-psychedelic-treatment">Disappointed supporters of psychedelic therapy</a>and the share prices of <a href="https://seekingalpha.com/symbol/MNMD">Psychedelics Industry Leaders</a> with the announcement. However, the FDA made recommendations on how the applying might be improved in order that MDMA could receive approval in the long run.</em></p>
<p><em>Another setback followed a couple of days later when the journal Psychopharmacology <a href="https://www.statnews.com/2024/08/11/mdma-ptsd-lykos-maps-retractions/">three papers on MDMA-assisted therapy withdrawn</a>and referred to “protocol violations that amount to unethical behavior,” particularly in a clinical trial.</em></p>
<p><em>The Conversation asked drug researchers <a href="https://search.asu.edu/profile/3022968">Benjamin Y. Fong</a> from Arizona State University on the implications of the FDA decision and what it means for the long run of psychedelic medicines.</em></p>
<h2>What is MDMA and what forms of illnesses can it treat?</h2>
<p><a href="https://www.dea.gov/factsheets/ecstasy-or-mdma-also-known-molly#">MDMA or midomafetamine</a>is colloquially referred to as &#8220;molly&#8221; or &#8220;ecstasy.&#8221; Technically it&#8217;s an amphetamine &#8211; just like the energetic ingredient in the eye deficit hyperactivity disorder drug Adderall &#8211; but MDMA is commonly classified as a psychedelic. It is taken into account to be more pleasurable than other amphetamines and is a preferred party drug because of this. Some researchers check with MDMA as an &#8220;empathogen&#8221; or &#8220;feeling enhancer.&#8221;</p>
<p>While MDMA is currently a <a href="https://www.dea.gov/drug-information/drug-scheduling">List I medicinal products</a> – meaning the Drug Enforcement Administration considers it highly dangerous and has no recognized medical use – <a href="https://healthjournalism.org/blog/2024/08/the-fda-could-approve-the-first-ptsd-treatment-in-20-years-what-to-know/">a series of clinical studies</a> indicate the advantages of using MDMA together with talk therapy for <a href="https://www.nature.com/articles/s41591-023-02565-4">Patients affected by PTSD</a>The FDA <a href="https://maps.org/news/media/press-release-fda-grants-breakthrough-therapy-designation-for-mdma-assisted-psychotherapy-for-ptsd-agrees-on-special-protocol-assessment-for-phase-3-trials/">received breakthrough therapy status for MDMA-assisted therapy</a> in 2017, which accelerated its development and review.</p>
<p>PTSD affects between <a href="https://undark.org/2024/08/05/fda-future-of-psychedelics-research/">9 to 13 million people annually</a> within the USA and <a href="https://www.nytimes.com/2023/09/14/health/mdma-ptsd-psychedelics.html">no novel treatments</a> developed for this disease. </p>
<p>Lykos Therapeutics <a href="https://news.lykospbc.com/2024-02-09-Lykos-Therapeutics-Announces-FDA-Acceptance-and-Priority-Review-of-New-Drug-Application-for-MDMA-Assisted-Therapy-for-PTSD">submitted an application for FDA approval</a> its version of MDMA-assisted therapy for PTSD in February 2024. In it, the drug is paired with a form of psychotherapy that <a href="https://doi.org/10.3389%2Ffpsyg.2022.887255">“inner healing intelligence</a>&#8220;, which <a href="https://maps.org/wp-content/uploads/2022/05/MDMA-Assisted-Psychotherapy-Treatment-Manual-V8.1-22AUG2017.pdf">Lykos defined</a> as “a person’s innate ability to heal the wounds of trauma.”</p>
<figure>
<p><iframe title="FDA rejects MDMA-assisted therapy for PTSD" width="1170" height="658" src="https://www.youtube.com/embed/ecosFiZZsAk?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p><figcaption><span class="caption">The FDA&#39;s rejection of MDMA-assisted therapy is a setback for the growing psychedelic drug development industry.</span></figcaption></figure>
<h2>Why did the FDA reject approval of Lykos’ MDMA-assisted therapy?</h2>
<p>In June 2024, a <a href="https://www.nytimes.com/2024/06/04/health/fda-mdma-therapy-ptsd.html">FDA advisory committee voted overwhelmingly against</a> the concept that the relevant clinical trials have proven the effectiveness of MDMA in treating PTSD. Equally crucial is the <a href="https://www.psychiatrictimes.com/view/reviewing-the-fda-advisory-committee-decision-on-mdma">The committee also voted against the thought</a> It has been shown that the advantages outweigh the risks, comparable to increased blood pressure and potential for abuse.</p>
<p>At the time, the advisory committee found fault with several points of Lykos&#39; application. First, it pointed to the issue of &#8220;functional unblinding,&#8221; the undeniable fact that most trial participants would know whether or not they were taking a robust psychoactive substance, which might skew the outcomes. This is an issue with any psychoactive drug, and Lykos critics imagine the corporate must have followed FDA policy to make use of an &#8220;active placebo&#8221; &#8211; a placebo that also has psychoactive effects &#8211; for comparison in its earlier clinical trials.</p>
<p>The panel also asked questions on <a href="https://www.vox.com/future-perfect/355687/fda-mdma-therapy-maps-lykos-cult">the shape of psychotherapy</a> used alongside MDMA, in addition to ethical concerns about <a href="https://www.statnews.com/2024/07/19/mdma-for-ptsd-fda-concerned-lykos-clinical-trial-misconduct-claims/">various types of misconduct</a> in Lykos&#39; studies. In certainly one of the corporate&#39;s studies, a participant reported <a href="https://www.biopharmadive.com/news/mdma-fda-advisers-vote-lykos-post-traumatic-stress-disorder-ptsd/718011/">sexual misconduct</a> by the therapists involved.</p>
<p>The FDA is just not sure by the votes of such advisory bodies, however it <a href="https://doi.org/10.1001%2Fjamahealthforum.2023.1718">follows her lead</a>Therefore, Friday’s decision was not an enormous surprise.</p>
<h2>What does the FDA’s decision mean for the long run of MDMA?</h2>
<p>The FDA requested a <a href="https://news.lykospbc.com/2024-08-09-Lykos-Therapeutics-Announces-Complete-Response-Letter-for-Midomafetamine-Capsules-for-PTSD">additional Phase 3 study</a>the phase of clinical trials wherein the security and effectiveness of a specific treatment is rigorously demonstrated as compared to straightforward treatment.</p>
<p>Lykos said the corporate will request a review of the choice and discuss the FDA&#39;s recommendations with the agency to make sure the corporate is on the proper track.</p>
<p>Lykos CEO Amy Emerson, who described the choice as “deeply disappointing,” believes that <a href="https://www.npr.org/sections/shots-health-news/2024/08/09/nx-s1-5068634/mdma-therapy-fda-decision-ptsd-psychedelic-treatment">“several years”</a> to perform the brand new process. </p>
<p>But with the journal Psychopharmacology <a href="https://www.statnews.com/2024/08/11/mdma-ptsd-lykos-maps-retractions/">Withdrawal of three articles related to this work</a>Lykos has a difficult road ahead of him.</p>
<h2>What impact could this decision have on the approval of other psychedelic drugs?</h2>
<p>A outstanding psychedelics company, Compass Pathways, is widely considered next in line for FDA approval of a psychedelic drug, with Phase 3 clinical trials for its <a href="https://compasspathways.com/our-work/comp360-psilocybin-treatment-in-trd/">synthetic psilocybin</a> are well underway. Other corporations are preparing Phase 3 trials of their very own proprietary compounds.</p>
<p>Following the advisory panel’s ruling in June, Compass stated that it <a href="https://www.washingtonpost.com/business/2024/06/08/psychedelic-drugs-mdma-fda-therapy/">not mate his drug</a> with a therapy just like the one Lykos carried out. <a href="https://www.morningstar.com/news/marketwatch/20240605246/psychedelic-medicine-stocks-drop-after-ecstasys-rocky-day-at-the-fda">Another company claimed</a> that it has a “better study design that is more consistent with FDA guidelines.”</p>
<p>Other psychedelic corporations clearly imagine they&#8217;ll succeed where Lykos failed.</p>
<h2>Are there any special challenges related to psychedelics?</h2>
<p>The FDA’s decision was <a href="https://www.washingtonpost.com/business/2024/06/08/psychedelic-drugs-mdma-fda-therapy/">more about Lykos&#39;</a> specific approach than an entire rejection of psychedelics for therapeutic use.</p>
<p>Yet developing psychedelic drugs is inherently a fragile process. The drugs induce a profoundly altered state that puts people in a vulnerable position. Some people within the industry I&#39;ve spoken to imagine that, given the character of the experience, it&#39;s almost inconceivable to avoid accusations of impropriety.</p>
<p>Most research also combines psychedelic drugs with some type of therapy or relief, and because the FDA has made clear, their role <a href="https://psychedelicalpha.com/news/live-coverage-fda-advisory-committee-reviews-mdma-assisted-therapy-for-ptsd">Evaluate medicines</a>not the psychotherapies that may accompany it.</p>
<p>The interaction between the drugs and the human think about treatment is the topic of some debate. Lykos&#39; missteps in its application make clear among the ways wherein corporations involved in developing psychedelic drugs face unique obstacles on the road to FDA approval.</p>
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<p><em>image credit : theconversation.com</em></p>
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