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	<title>Manipulating &#8211; USA NEWS LIVE</title>
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	<title>Manipulating &#8211; USA NEWS LIVE</title>
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	<item>
		<title>Crimes and public security &#124; Ex-tagord research coordinator, which was convicted of manipulating with cancer database</title>
		<link>https://bloggingthree.soflytech.com/2025/02/crimes-and-public-security-ex-tagord-research-coordinator-which-was-convicted-of-manipulating-with-cancer-database/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Tue, 25 Feb 2025 12:28:58 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[cancer]]></category>
		<category><![CDATA[convicted]]></category>
		<category><![CDATA[coordinator]]></category>
		<category><![CDATA[crimes]]></category>
		<category><![CDATA[database]]></category>
		<category><![CDATA[Extagord]]></category>
		<category><![CDATA[Manipulating]]></category>
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		<category><![CDATA[Security]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=25200</guid>

					<description><![CDATA[On February 21, a jury found the 66-year-old near Mangi due to two cases of intentional damage to a protected computer and numerous access to a protected computer without permission, said the US law firm on Monday in a press release. From September 2012 to August 2013, Mangi worked as a coordinator for clinical research [&#8230;]]]></description>
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<p>On February 21, a jury found the 66-year-old near Mangi due to two cases of intentional damage to a protected computer and numerous access to a protected computer without permission, said the US law firm on Monday in a press release.</p>
<p>From September 2012 to August 2013, Mangi worked as a coordinator for clinical research coordinator within the office for clinical studies in cancer on the Stanfords National Cancer Institute.</p>
<p>According to the authorities, Mangi was assigned to a study for breast cancer patients sponsored by Genentech. In the study, attempts were made to find out the safety and effectiveness of a brand new, experimental pharmaceutical treatment for patients with metastatic or locally advanced breast cancer. Her tasks included entering patients medical data to the study database.</p>
<p>On August 19, 2013, Mangi was released and her manager tried to revoke her computer access and privileges. The supervisor sent Genentech by e -mail to finish Mangi&#39;s access to the database, but their login information was only deactivated the subsequent day.</p>
<p>The jury found that on August 19, after Stanford had revoked their access, the study database had registered and replaced the patient&#39;s medical data through faulty information and insults about their former supervisor, the US law firm said.</p>
<p>In response to this, Stanford entered an internal examination, returned all data in regards to the study participants and reported the incident of the US Food and Drug Administration.</p>
<p>According to the authorities, Mangi&#39;s actions of Mangi led 1000&#8217;s of dollars at Stanford University and Stanford School of Medicine.</p>
<p>&#8220;Nahed Mangi has deliberately transformed into a breast cancer research database by entering incorrect information and personal insults,&#8221; said the incumbent US lawyer Patrick Robbins in an announcement. &#8220;The jury&#39;s judgment blames the accused for their crimes.&#8221;</p>
<p>When she was convicted on July 21, Mangi can be faced with the intentional damage of a protected computer and a maximum punishment of 1 yr in prison for access to a protected computer without the approval of a maximum punishment of 10 years in prison.</p>
<p>Originally published: <time datetime="2025-02-24 21:09:03">February 24, 2025 at 9:09 p.m. PST</time></p>
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<p><em>image credit : www.mercurynews.com</em></p>
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		<title>How the 14th Amendment prevents state legislatures from manipulating presidential elections</title>
		<link>https://bloggingthree.soflytech.com/2024/09/how-the-14th-amendment-prevents-state-legislatures-from-manipulating-presidential-elections/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Sun, 01 Sep 2024 13:50:17 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[14th]]></category>
		<category><![CDATA[Amendment]]></category>
		<category><![CDATA[elections]]></category>
		<category><![CDATA[legislatures]]></category>
		<category><![CDATA[Manipulating]]></category>
		<category><![CDATA[presidential]]></category>
		<category><![CDATA[prevents]]></category>
		<category><![CDATA[state]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=13591</guid>

					<description><![CDATA[Donald Trump&#39;s efforts to overturn the results of the 2020 presidential election not only failed, but were also based partly on a misinterpretation of the U.S. Constitution. as our recent evaluation arguesThe corresponding constitutional provision dates from the period immediately after the Civil War and was recognized by contemporaries as a central protective mechanism of [&#8230;]]]></description>
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<p>Donald Trump&#39;s efforts to overturn the results of the 2020 presidential election not only failed, but were also based partly on a misinterpretation of the U.S. Constitution. <a href="https://arizonastatelawjournal.org/wp-content/uploads/2024/05/Froomkin_Pub.pdf">as our recent evaluation argues</a>The corresponding constitutional provision dates from the period immediately after the Civil War and was recognized by contemporaries as a central protective mechanism of American democracy.</p>
<p>In November 2020, when it became clear that Trump had lost the favored vote and would lose the Electoral College, Trump and his supporters organized a <a href="https://www.nytimes.com/interactive/2024/01/08/us/trump-2020-overturn-timeline.html">Print campaign</a> to steer the legislatures of several states whose residents voted for Joe Biden to appoint electors who would support Trump&#39;s re-election within the Electoral College vote.</p>
<p>Trump and his allies contacted Republican lawmakers in Michigan, Georgia and Pennsylvania to <a href="https://www.govinfo.gov/content/pkg/GPO-J6-REPORT/html-submitted/ch2.html">State parliaments</a> to overturn the end result of the favored vote. Ginni Thomas, the wife of Supreme Court Justice Clarence Thomas, <a href="https://www.washingtonpost.com/investigations/2022/06/10/ginni-thomas-election-arizona-lawmakers/">via email to GOP lawmakers in Arizona</a>and called on them to “ensure that a clean slate of electors is elected.”</p>
<p>These efforts were based on a provision of the Constitution in Article II, Section 1, which states: “Each State shall appoint <a href="https://constitution.congress.gov/constitution/article-2/#article-2-section-1-clause-2">in the manner prescribed by the legislator</a>a number of electors.” Trump and his supporters wanted state legislatures to discard their residents’ votes and easily appoint electors who would support Trump’s re-election campaign.</p>
<p>As a part of their efforts, Trump and his supporters claimed that the Constitution allows state legislatures to <a href="https://lawecommons.luc.edu/luclj/vol51/iss2/3">directly elect an inventory of electors</a> and not using a referendum.</p>
<p>But they were improper. There was already a safeguard in place – and it still exists today – to forestall this approach from getting used to <a href="https://azmirror.com/2024/02/15/republican-resolution-shows-intent-to-bypass-voters-in-the-2024-presidential-election/">undermine the 2024 presidential election</a>.</p>
<h2>An try and protect the facility of the voters</h2>
<figure class="align-right zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:170.46413502109706%;--background-color:#807f80"><img decoding="async" alt="" class="lazyload" src="https://images.theconversation.com/files/614355/original/file-20240819-19-wspmii.png?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=237&#038;fit=clip" srcset="https://images.theconversation.com/files/614355/original/file-20240819-19-wspmii.png?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=1024&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/614355/original/file-20240819-19-wspmii.png?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=1024&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/614355/original/file-20240819-19-wspmii.png?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=1024&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/614355/original/file-20240819-19-wspmii.png?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=1286&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/614355/original/file-20240819-19-wspmii.png?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=1286&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/614355/original/file-20240819-19-wspmii.png?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=1286&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">A message published in South Carolina on August 19, 1868, provides insight into the then-understanding of Section 2 of the 14th Amendment.</span><br />
              <span class="attribution"><a class="source" href="https://www.newspapers.com/image/73824534/?match=1&#038;amp%3Bterms=%22then%20the%20basis%20of%20representation%20in%20such%20State%20must%20be%20reduced%20by%20the%20number%20of%20all%20the%20voters%2C%20which%20is%20to%20say%20that%20it%20is%20to%20have%20no%20basis%20of%20representation%20at%20all%22">The Anderson Intelligencer via newspapers.com</a></span><br />
            </figcaption></figure>
<p>In just about all states <a href="https://www.ncsl.org/elections-and-campaigns/the-electoral-college">Candidate who receives probably the most votes</a> For the presidency, the candidate receives all of the votes of the electors of the respective state. <a href="https://www.ncsl.org/elections-and-campaigns/the-electoral-college">Nebraska and Maine have small exceptions</a> – but under the laws of those states, nearly all of electoral votes still go to whoever receives nearly all of votes nationwide.</p>
<p>In the late 1860s, when the 14th Amendment was drafted and ratified, the identical was true – although the proper to vote <a href="https://www.archives.gov/milestone-documents/19th-amendment">limited to men until 1920</a>and states often denied or restricted the proper to vote for some residents, particularly members of ethnic minorities. After the Civil War, Congress attempted to cut back barriers to voting for black men, particularly within the South. </p>
<p>When Congress debated the 14th Amendment in 1866, its drafters drafted Section 2 in a <a href="https://doi.org/10.1353/cwe.2024.a919853">Efforts to force reluctant white Southerners to grant black men the proper to vote</a>.</p>
<p>Section 2 of the 14th Amendment states: “<a href="https://constitution.congress.gov/constitution/amendment-14/#amendment-14-section-2">if the right to vote in every election</a> for choosing Electors for President and Vice President of the United States … is denied … or in any manner abridged …, the basis of representation” for that State within the United States House of Representatives “shall be reduced” in proportion to the quantity of the abridgement.</p>
<p>So if a state were to deprive one in all its residents of the proper to vote, it might immediately <a href="https://arizonastatelawjournal.org/wp-content/uploads/2024/05/Froomkin_Pub.pdf">lose the identical percentage of seats within the House of Representatives</a> as a percentage of people that were disenfranchised.</p>
<p>Just just a few weeks after ratification, this provision was questioned for the primary time. </p>
<p>The Republican-dominated Reconstruction Legislature of Florida <a href="https://perma.cc/LS26-Y5TW">decided to carry presidential elections without popular vote</a>. The Democrats—then the party that supported black disenfranchisement—were furious. Many Southern newspaper journalists, still indignant concerning the ratification of the 14th Amendment, saw a chance to show the amendment against its Republican authors.</p>
<p>&#8220;<a href="https://www.newspapers.com/image/72230217/?match=1&#038;terms=%22is%20that%20if%20in%20any%20State%20the%20election%20of%20Presidential%20electors%20%22">The easy conclusion is that if in a state</a> “If the choice of Presidential Electors is no longer left to the people, and placed in the hands of the Legislature, the whole citizenry of the State… will be excluded from it,” wrote the Charleston Daily News on August 10, 1868.</p>
<p>This was not a rare or local view: nine days later, the Anderson Intelligencer, a South Carolina newspaper, published a brief article attributed to the New York Herald that stated similarly:</p>
<blockquote>
<p>&#8220;<a href="https://www.newspapers.com/image/73824534/?match=1&#038;terms=%22then%20the%20basis%20of%20representation%20in%20such%20State%20must%20be%20reduced%20by%20the%20number%20of%20all%20the%20voters%2C%20which%20is%20to%20say%20that%20it%20is%20to%20have%20no%20basis%20of%20representation%20at%20all%22">If all voters in a state are denied the proper to decide on presidential electors</a>then the premise of representation on this state have to be reduced by the variety of all voters, that&#8217;s, there must not be any basis of representation in any respect.&#8221;</p>
</blockquote>
<p>These opinion pieces don&#8217;t have any legal authority, but they reflect a standard – albeit controversial – <a href="https://timesmachine.nytimes.com/timesmachine/1868/08/08/78952288.html?pageNumber=4">Understanding the provisions of the 14th Amendment</a> on the time of its passage. No one filed a lawsuit, so no court had the chance to comment. And the Republican-dominated Congress had no qualms about accepting electoral votes &#8211; even and not using a popular vote &#8211; for the Republican presidential candidate.</p>
<h2>The right to have your vote counted</h2>
<p>After the 2020 election, Congress took steps to make clear that electors have to be those who select presidential electors. A law passed in 2022 revised the federal law governing electoral college selection to require state legislatures to find out their state&#39;s method for choosing electors before Election Day and <a href="https://www.ncsl.org/state-legislatures-news/details/what-the-electoral-count-reform-act-means-for-states">can not change it after the votes have been forged</a>. </p>
<p>This clarification is consistent with, and even strengthens, the provisions of Section 2 of the 14th Amendment.</p>
<p>As our evaluation shows, a direct election of electors by a state legislature would disenfranchise all voters within the state. After all, the proper to vote is the proper to have one&#39;s vote counted, not the proper to have one&#39;s candidate win. </p>
<p>Thus, even when the legislature were to pick out a slate of electors that might have received significant support in the favored election, the legislature&#39;s decision would limit the rights of each voter within the state. Disenfranchisement is determined by whether the people or the legislature selects the electors, not on which electors are chosen.</p>
<p>If all voters in a state are disenfranchised, Section 2 requires that the <a href="https://arizonastatelawjournal.org/wp-content/uploads/2024/05/Froomkin_Pub.pdf">The state’s representation within the House of Representatives will probably be immediately and mechanically reduced to zero</a>. The Constitution elsewhere provides that the representation of every state within the Electoral College <a href="https://constitution.congress.gov/constitution/article-2/#article-2-section-1-clause-2">Total of the delegations of the House of Representatives and the Senate of the State</a>. </p>
<p>If a state doesn&#8217;t have a representative within the House of Representatives, it might only have two electors, making its influence on the presidential election negligible and largely irrelevant.</p>
<h2>A single exception</h2>
<p>To date, it&#8217;s the only case, other than Florida in 1868, during which a state legislature has chosen its presidential electors and not using a popular vote. <a href="https://ir.law.fsu.edu/cgi/viewcontent.cgi?article=1609&#038;context=lr">got here in 1876</a>. </p>
<figure class="align-center zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:68.96551724137932%;--background-color:#85827d"><img decoding="async" alt="Copperplate engraving of portraits of two men." class="lazyload" src="https://images.theconversation.com/files/615878/original/file-20240827-18-eoeuuf.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/615878/original/file-20240827-18-eoeuuf.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=414&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/615878/original/file-20240827-18-eoeuuf.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=414&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/615878/original/file-20240827-18-eoeuuf.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=414&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/615878/original/file-20240827-18-eoeuuf.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=520&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/615878/original/file-20240827-18-eoeuuf.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=520&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/615878/original/file-20240827-18-eoeuuf.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=520&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">Democrat Samuel Tilden (left) and Republican Rutherford Hayes ran for president within the 1876 election.</span><br />
              <span class="attribution"><a class="source" href="https://www.gettyimages.com/detail/news-photo/the-presidental-contest-in-america-samuel-tilden-the-news-photo/464769291">Universal History Archive/Universal Images Group via Getty Images</a></span><br />
            </figcaption></figure>
<p><a href="https://millercenter.org/the-presidency/educational-resources/disputed-election-1876">Electoral fraud, political violence and voter intimidation</a> <a href="https://kansaspress.ku.edu/9780700617876/">undermined the integrity of the 1876 presidential election</a>The Constitution of Colorado, which was newly recognized as a state, provided that the legislature <a href="https://archives.colorado.gov/sites/archives/files/Colorado%20Constitution.pdf">In 1876, elect the state&#39;s presidential electors and not using a popular vote</a>Overshadowed by an exceptionally bitter election, the number of Colorado’s presidential electors by the legislature <a href="https://duurjportal.com/index.php/duurj/article/view/221/119">relatively little attention or debate</a>.</p>
<p>Overall, one can conclude that Southern newspapers in 1868 read the text of Section 2 accurately. The authors could have been cynical opportunists looking for to defend an untenable racist hierarchy, but their interpretation of the text is cheap.</p>
<p>The meaning of Section 2 is obvious and provides for severe penalties if a state doesn&#8217;t allow its residents to vote for presidential electors. The 14th Amendment continues to guard American democracy greater than 150 years after its ratification.</p>
</p></div>
<p><em>image credit : theconversation.com</em></p>
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		<title>Manipulating cells that emit their behavior might help scientists explore their inner workings</title>
		<link>https://bloggingthree.soflytech.com/2024/05/manipulating-cells-that-emit-their-behavior-might-help-scientists-explore-their-inner-workings/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Fri, 31 May 2024 16:57:06 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[behavior]]></category>
		<category><![CDATA[cells]]></category>
		<category><![CDATA[emit]]></category>
		<category><![CDATA[explore]]></category>
		<category><![CDATA[Manipulating]]></category>
		<category><![CDATA[scientists]]></category>
		<category><![CDATA[workings]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=5026</guid>

					<description><![CDATA[Waves are omnipresent in nature and technologyWhether it&#39;s the rise and fall of the tides or the swing of a clock&#39;s pendulum, the predictable rhythms of the waves create a signal that&#39;s easy to trace and distinguish from other varieties of signals. Electronic devices equivalent to laptops and Wi-Fi routers or cell phones and cell [&#8230;]]]></description>
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<div itemprop="articleBody">
<p>Waves are <a href="https://wisconsin.pbslearningmedia.org/collection/nova/t/physical-sciences/waves-applications-in-technology/">omnipresent in nature and technology</a>Whether it&#39;s the rise and fall of the tides or the swing of a clock&#39;s pendulum, the predictable rhythms of the waves create a signal that&#39;s easy to trace and distinguish from other varieties of signals. </p>
<p>Electronic devices equivalent to laptops and Wi-Fi routers or cell phones and cell towers use radio waves to send and receive data. Similarly, scientists can use a special variety of wave to transmit a special variety of data: signals from the invisible processes and dynamics underlying cellular decision-making.</p>
<p>I&#8217;m a <a href="https://scholar.google.com/citations?user=Y3GBxtsAAAAJ&#038;hl=en">synthetic biologist</a>and mine <a href="https://www.coylelab.org/">Research group</a> developed a technology that <a href="https://doi.org/10.1016/j.cell.2023.12.007">sends a wave of genetically modified proteins</a> They travel through a human cell to offer insight into the hidden activities that energize cells after they&#39;re healthy and harm them after they go haywire.</p>
<h2>Waves are a strong engineering tool</h2>
<p>The oscillating behavior of waves is one reason why they represent effective patterns in technology. </p>
<p>For example, controlled and predictable changes in wave oscillations may be used to encode data equivalent to voice or video information. In the case of <a href="https://phys.libretexts.org/Bookshelves/University_Physics/Physics_(Boundless)/23%3A_Electromagnetic_Waves/23.1%3A_The_Electromagnetic_Spectrum">Radio, every station</a> is assigned a novel electromagnetic wave that vibrates at its own frequency. These are the numbers you see on the radio scale. </p>
<figure class="align-center zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:70.026525198939%;--background-color:#868686"><img decoding="async" alt="Animated diagram showing a signal wave (gentle hills and valleys), AM waves (more waves fit the shape of hills and valleys), and FM waves (clusters of waves that spread out slightly in the valleys of the signal)." class="lazyload" src="https://images.theconversation.com/files/596116/original/file-20240523-17-sezsps.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/596116/original/file-20240523-17-sezsps.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=420&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/596116/original/file-20240523-17-sezsps.gif?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=420&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/596116/original/file-20240523-17-sezsps.gif?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=420&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/596116/original/file-20240523-17-sezsps.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=528&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/596116/original/file-20240523-17-sezsps.gif?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=528&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/596116/original/file-20240523-17-sezsps.gif?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=528&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">Waves may be modulated to transmit several types of information, equivalent to FM and AM radio.</span><br />
              <span class="attribution"><a class="source" href="https://commons.wikimedia.org/wiki/File:Amfm3-en-de.gif">Berserkerus/Wikimedia Commons</a>, <a class="license" href="http://creativecommons.org/licenses/by-sa/4.0/">CC BY-SA</a></span><br />
            </figcaption></figure>
<p>Scientists can extend this technique to living cells. My team used <a href="https://doi.org/10.1016/j.cell.2023.12.007">Waves of proteins</a> to remodel a cell right into a microscopic radio station that sends data about its activity in real time to check its behavior.</p>
<h2>Turning cells into radio transmitters</h2>
<p>To study the inside of a cell, a variety of wave is required that may specifically connect with and interact with the mechanism and components of a cell. </p>
<figure class="align-right zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:100.0%;--background-color:#000000"><img decoding="async" alt="Animation of cyan and manganese waves forming a spiral" class="lazyload" src="https://images.theconversation.com/files/596110/original/file-20240523-19-14qjmq.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=237&#038;fit=clip" srcset="https://images.theconversation.com/files/596110/original/file-20240523-19-14qjmq.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=600&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/596110/original/file-20240523-19-14qjmq.gif?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=600&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/596110/original/file-20240523-19-14qjmq.gif?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=600&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/596110/original/file-20240523-19-14qjmq.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=754&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/596110/original/file-20240523-19-14qjmq.gif?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=754&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/596110/original/file-20240523-19-14qjmq.gif?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=754&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">The bacterial proteins MinD (cyan) and MinE (magenta) can self-organize into spiral patterns.</span><br />
              <span class="attribution"><a class="source" href="https://commons.wikimedia.org/wiki/File:Min_Spirals.gif">CellfOrganized/Wikimedia Commons</a>, <a class="license" href="http://creativecommons.org/licenses/by-sa/4.0/">CC BY-SA</a></span><br />
            </figcaption></figure>
<p>While electronic devices are made up of wires and transistors, cells are constructed from and controlled by a various collection of chemical constructing blocks. <a href="https://www.khanacademy.org/science/biology/macromolecules/proteins-and-amino-acids/a/introduction-to-proteins-and-amino-acids">so-called proteins</a>. Proteins perform a wide range of functions throughout the cell, from extracting energy from sugar to deciding whether the cell should grow. </p>
<p>Protein waves are generally rare in nature, but some bacteria naturally produce waves of two proteins, the <a href="https://doi.org/10.1073/pnas.96.9.4971">MinD and MinE</a> – normally referred to collectively as MinDE – to assist them divide. My team discovered that introducing MinDE into human cells causes the proteins to reorganize and produce an astonishing number of <a href="https://youtu.be/jgcSG8z9gBs?list=PLx2v1NUlEZF9lssRPmT4eD4f4yCoaysiV&#038;t=6">Waves and patterns</a>.</p>
<p>MinDE protein waves don&#8217;t interact with other proteins in human cells. However, we found that MinDE <a href="https://doi.org/10.1016/j.cell.2023.12.007">flippantly constructed</a> to answer the activity of certain human proteins which are answerable for deciding whether to grow, send signals to neighboring cells, move, and divide.</p>
<figure class="align-center zoomable">
<div class="placeholder-container" style="--aspect-ratio-percent:50.0%;--background-color:#4f4d2b"><img decoding="async" alt="Left: Population of hundreds of human cells with protein oscillations. Right: decoded cell state data from each individual cell within the population, color-coded by activity" class="lazyload" src="https://images.theconversation.com/files/597204/original/file-20240529-17-96rz9x.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/597204/original/file-20240529-17-96rz9x.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=300&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/597204/original/file-20240529-17-96rz9x.gif?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=300&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/597204/original/file-20240529-17-96rz9x.gif?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=300&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/597204/original/file-20240529-17-96rz9x.gif?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=377&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/597204/original/file-20240529-17-96rz9x.gif?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=377&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/597204/original/file-20240529-17-96rz9x.gif?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=377&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">By introducing MinDE into human cells, visual patterns are created that may indicate changes in protein activity within the cell.</span><br />
              <span class="attribution"><span class="source">Scott Coyle and Chih-Chia Chang</span>, <a class="license" href="http://creativecommons.org/licenses/by-nd/4.0/">CC BY-ND</a></span><br />
            </figcaption></figure>
<p>The protein dynamics that control these cellular functions are often difficult to detect and study in living cells since the activity of proteins is mostly invisible even to high-performance microscopes. Disrupting these protein patterns <a href="https://doi.org/10.1073/pnas.0334858100">is by</a> <a href="https://doi.org/10.1126/science.aao3048">Core of many</a> Cancer and developmental disorders. </p>
<p>We have made connections between MinDE protein waves and the activity of proteins answerable for necessary cellular processes. Now, the activity of those proteins triggers changes within the frequency or amplitude of the protein wave, identical to an AM/FM radio. Using microscopes, we are able to detect and record the unique signals that individual cells emit, after which decode them to recreate the dynamics of those cellular processes.</p>
<p>We&#39;ve only just begun to scratch the surface of the ways scientists can use protein waves to check cells, and if the history of waves in technology is any indication, their potential is gigantic.</p>
</p></div>
<p><em>image credit : theconversation.com</em></p>
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