Kris Jenner listed her legendary hidden hills estate for 13.5 million US dollars today.

For over a decade, this extensive 8,860 square meter manor house within the Mediterranean style has been the backdrop for a big a part of the drama, which was shown in “Keeping Up with with the Kardashians” and makes it “a piece of television history”.

At least that's what the list calls it.

The long-standing reality series focused on the Mixed Kardashian and Jenner family, especially on the sisters Kim, Kourtney and Khloé Kardashian in addition to their half-sisters Kendall and Kylie Jenner. After 20 seasons that stretched over 14 years, the show accomplished in 2021, however the attraction of the home stays.

“It is a home in which a family lived her life, with good times, bad times, children and all kinds of evolution”, Tomer Fridman from Christie's International Real Estate Southern California. The listing Agent told the New York Times, who first reported the property on the market.

Filling image windows fill the inside with natural light and frame views on the lavish terrain, which incorporates a pool, a spa, a fire, a cabana, a kitchen outdoor and a dining area.

The primary suite opens to a walk -in balcony with a view of the over 1.5 hectares. In this retreat, a fire heats the bedroom. A spa-like bathroom with a steam shower, a walk-in wardrobe and a non-public gym contribute to the offers.

A dedicated office adds functions that make the home “perfect for wasteful life and productivity”, the list says.

On Propertyshark.com, viewed records reveal that Kris Jenner and her ex, Caitlyn Jenner, bought the home for $ 4 million in March 2010. In 2014, Caitlyn Jenner transferred ownership of the property to Kris Jenner.

You accomplished your divorce in 2015 after 24 years of marriage.

Kris Jenner, 69, is now in a relationship with the talent manager Corey Gamble, 44.

In a proof to the New York TimesShe said: “I shared so many unforgettable memories in this incredible home with my family, and I am pleased that it will start a new chapter with its next owners.”

The time for colds and coughs is here again. But while Influenza and RSV activity is “moderate and increasing” in California.COVID activity is unusually low for the vacation season.

The latest weekly update from the California Department of Public Health shows the flu test positivity rate increased nearly 4 percentage points to 13.2% in per week (as of Dec. 14, essentially the most recent data available). The COVID positivity rate is 2.3%, a rise of 0.2 percentage points from the previous week.

The The Department of Health's weekly updates are published most Fridaysbut respiratory virus reports for the last two weeks of the yr should not reported until January.

“COVID is increasing, but flu is currently leading the way,” said Dr. John Swartzberg, clinical professor emeritus on the UC Berkeley School of Public Health.

Since COVID emerged at the top of the 2019-2020 respiratory virus season, it has been by far the deadliest respiratory virus for which the state collects and publishes weekly data, even though it has killed fewer people in each of the previous few years in comparison with early within the yr Pandemic.

Since July 1, there have been 1,873 COVID deaths across California — with the summer surge not easing until late August — and 89 flu deaths.

After spiking in late summer, COVID deaths hit latest lows again, and as we enter the brand new yr, testing, hospitalizations and deaths are only starting to indicate signs of a rise.

“If you look at the wastewater data, the number of COVID-19 infections is clearly increasing across the United States and particularly in California,” Swartzberg said.

In Santa Clara County, wastewater measurements show the identical pattern. County public health officials are monitoring local wastewater and testing it for virus levels in 4 local sewage sheds. Accordingly aggregated wastewater surveillance data monitored by the state health departmentCOVID levels across the Bay Area region have just moved from low to moderate and are rising.

Influenza concentrations began to rise in November and continued to rise through December. RSV (Respiratory Syncytial Virus) has been on the rise for the reason that end of November. Swartzberg said RSV could have peaked, but COVID continues to be expected to spike later within the season.

After a chronic surge that lasted from June to August, concentrations of COVID within the county's 4 sewers have been low since mid-October, with concentrations throughout the county at high levels more often than not.

Now December COVID levels seem like at their lowest levels lately. “It looks better than last year and last year was the best winter we had,” Swartzberg said.

Even though the variety of COVID vaccinations is lower than in the primary few years of their availability, there continues to be some immunity within the population against this summer's surge. But the number of people that have received the newest vaccination is, in Swartzberg’s opinion, “disappointingly low”. Influenza vaccination rates are higher, but nowhere near early COVID vaccination rates.

A brand new RSV vaccine beneficial for the very young, those over 75 and another high-risk people could help result in an overall improvement in virus rates this yr in comparison with last, Swartzberg said. Since this respiratory virus season began on July 1, California has reported 21 deaths as a result of the virus, including 4 children, in comparison with 33 at the identical time last yr. “RSV appears to be on track for a better year,” he said.

And while much has modified, including the prevalence of COVID at this yr's holiday dinners in comparison with past years, Swartzberg's general advice hasn't modified: “Please get vaccinated. It's not too late.”

Originally published: December 31, 2024 at 1:45 pm PST

Unimaginable pain and restlessness. Vomiting so frequent and violent that it could actually result in perforation of the esophagus. Blood pressure and heart rate are so high that they damage the center. Sweat soaking through clothes and sheets. Nervous sensitivity that makes even the gentlest touch painful. A persistent panic attack that’s provoked and worsened by even on a regular basis activities and conversations.

The withdrawal symptoms of “Tranq dope” – the mix of the synthetic opioid fentanyl and the Animal tranquilizer xylazine The dominates Philadelphia's street supply of opioids – tends to much worse than those that have experienced even the heaviest heroin users of the past.

So it's no surprise that folks are doing all the things they will to get ahead of them. This includes leaving the hospital before treatment is complete.

I’m a Associate Professor of Emergency Medicine who worked as an emergency room physician in Center City and South Philadelphia for a decade. I spent most of my time leading projects to enhance look after individuals who use drugs.

Starting in 2022, our team – a bunch of emergency and addiction medicine specialists – began experimenting with latest approaches to treating narcotic withdrawal.

We were capable of reduce the likelihood of those patients leaving the hospital before completing treatment by greater than half – from 10% to almost 4%.

We also reduced the severity of their suffering and cut their withdrawal scores – or how they rate their pain and other symptoms – by greater than half.

Conventional treatments don't work

Before Tranq Dope, treating opioid withdrawal within the emergency room was relatively easy well studied, conventional Protocols.

For patients without chronic pain, health care providers began taking buprenorphine, known by the brand name Suboxone, when patients began experiencing withdrawal symptoms.

Buprenorphine works by partially, reasonably than completely, stimulating the opioid receptors within the body. This subtle difference eases withdrawal symptoms but reduces the chance of overdose if patients proceed to make use of other opioids. It is within the truest sense of the word saves lives.

However, Tranq Dope presented even greater challenges.

fentanyl and others There are dozens of synthetic opioids 100 times stronger than heroin. Xylazine, meanwhile, adds symptoms of sedative withdrawal to the combination: restlessness, adrenaline activation, and agitation.

As synthetic opioids have develop into ubiquitous in Philadelphia's drug supply over the past decade, The variety of overdose deaths in the town has tripled. These numbers are begins to sinkfor Reasons that remain unclear.

Meanwhile, Tranq users began sharing horror stories about buprenorphine. They refused the medication as a consequence of a phenomenon called “accelerated withdrawal.” Accelerated withdrawal is a condition through which taking buprenorphine paradoxically worsens withdrawal symptoms reasonably than improving them. Due to the severity of their symptoms, some patients with severe illnesses even require treatment within the intensive care unit.

In addition, when patients took buprenorphine, their withdrawal symptoms could not be effectively controlled, even at very high doses. We were adrift.

Patients demand discharge

When individuals with serious substance use disorders are admitted to the hospital, even compassionate staff sometimes lose patience.

Stretcher placement in a loud, chaotic environment, withdrawal, and prior traumatic experiences in healthcare may cause patients to develop into reactive. They may press ringtones repeatedly, use inappropriate language, make impulsive decisions, or secretly bring medication to the hospital.

This creates so much Stress for nurses and employees and distracts from the care of others.

So when patients demand to go away before treatment is accomplished, exhausted care teams are sometimes quick to offer in. Traditionally this was known as “leaving.”against medical advice“, but now it means “patient-controlled discharge.”

Patient-directed discharge is related to higher rates mortality, everlasting disability And Rehospitalization.

Rates of patient-directed discharge could be 10 to 50 times higher in individuals with opioid use disorder in comparison with the overall population.

A Cycle of mistrust It can even develop when the expectation that a patient might leave causes the care team to develop into less engaged, which in turn can result in patients becoming disengaged reasonably go.

In staff meetings, some compared the challenges of caring for these individuals to those in the course of the most difficult periods of the COVID-19 pandemic.

New approach required

Many physicians have been reluctant to think about other options for treating opioid withdrawal. I believe there are two essential reasons for this. One is the dearth of Food and Drug Administration approval for alternative treatments. The other reason is that federal regulations view addiction as a behavioral disorder reasonably than a medical condition, effectively separating most physicians from addiction treatment for these individuals.

As fentanyl and xylazine became ubiquitous in Philadelphia's street drugs, local hospitals reported astronomical rates of patient-directed discharges of those patients. This occurred despite one of the best efforts of hospital staff, who’ve extensive experience in conventional opioid withdrawal treatment.

In 2021, an editorial within the journal Annals of Internal Medicine made the case Use of short-acting opioids for some patients’ opioid withdrawal – which is already the case common practice In Canada. Short-acting opioids are medications that doctors traditionally use to treat acute pain.

Hospitals in Philadelphia began experimenting with the usage of these previously banned drugs. This included our team at Jefferson Health.

Oxycodone, hydromorphone and ketamine

By using short-acting opioids reminiscent of oxycodone or hydromorphone together with a low-dose version of buprenorphine, we’ve been capable of prevent accelerated withdrawal and treat opioid withdrawal and pain in our patients.

The low-dose bupenorphine could be increased to constant doses over time. This shows patients that the drug is protected and offers them a bridge to long-term treatment.

The short-acting opioids replace the opioids your body is desperately looking for. They reduce their pain and misery and reduce in weight when their symptoms are under control.

Patients with opioid use disorder often do all the things they will to remain out of the hospital for fear of withdrawal. The query of how one can take care of withdrawal symptoms is due to this fact often the primary priority during a hospital stay. We see this even after they have conditions that require complicated and time-sensitive treatments.

Due to the big amount of opioids that a lot of our patients eat, we also give them strong medications or “Additional therapies“to enrich the results of short-acting opioids and low-dose buprenorphine. One of those is ketamine, an anesthetic that affects nerve impulses and is increasingly getting used as a treatment depression, Post-traumatic stress disorder And Substance use disorders.

Ketamine can be an efficient painkiller that may potentiate the results of opioids Reduce the variety of doses needed.

We also add muscle relaxants – which work similarly to xylazine – together with anti-nausea medications and IV fluids to offer patients a likelihood of healing.

Side effects and future problems

The risk of significant unintended effects was minimal in patients receiving our medications. The few patients who experienced serious unintended effects had other acute medical problems which will have contributed to the unintended effects. Almost all the unintended effects we saw were mild and went away on their very own.

As strong synthetic opioids and other contaminants As an increasing number of U.S. cities develop into more prevalent, emergency rooms are having to determine how one can look after withdrawal patients in order that they don't drop out of treatment.

We hope this work will encourage others to higher serve patients affected by this complicated and serious disease.

The Bay Area, led by Silicon Valley, has been the worldwide epicenter of innovation for greater than five many years. But as a vital national election approaches, some are questioning whether our region can proceed to resist competition from other technology-rich regions.

This concern is logical: the rise of distant work and the high cost of living in our region may prompt some firms and talent to maneuver elsewhere. Yet despite the challenges of those uncertain times, our economy has remained dynamic and resilient, even when other regions struggle to duplicate our success.

To protect this economic strength, we must make sure the Bay Area produces the subsequent wave of breakthrough technologies, address the region's housing crisis, and improve access to capital for a various group of company founders.

With the subsequent big shift looming – the rise of AI – our region stays at the middle of the motion. According to Crunchbase, in 2023, greater than 50% of all global enterprise capital funding for AI-related startups went to firms headquartered within the Bay Area. An entire ecosystem has been built – semiconductor R&D, large language model development, and corporations working to integrate AI into existing platforms and products.

Beyond AI, we would like to be home to the subsequent transformative technologies – fully autonomous transportation, fusion energy, advanced robotics and neural networks, quantum computing, and other cutting-edge technologies.

To do that, we must make it easier for start-ups and other firms to locate and expand. We must provide reliable, clean energy and modern facilities to support research, development and manufacturing. We must remove outdated and expensive regulations and red tape, and avoid punitive taxes that would change the selections of company leaders about where to locate their headquarters.

We won’t ever win the battle to be the bottom cost region. That is why we must proceed to play to our strengths and support policies that encourage investment. What is at stake? Opportunities and jobs, not only within the technology sector, but in all industries.

At the identical time, inexpensive housing is at crisis levels. We have to dramatically increase the variety of housing units in our region and further streamline permitting processes. We must also be open to progressive ideas, akin to 3D printing of recent homes, which has turn into a reality lately.

In addition, we must improve access to capital for entrepreneurs from a wide selection of backgrounds. Our region receives between 25 and 40 percent of all enterprise capital investments within the country. It is critical that Silicon Valley stays a haven for startups by providing early-stage support, strengthening partnerships with leading universities and colleges, encouraging the event of young leaders, and connecting them to meaningful profession paths.

No other region has managed to duplicate the Bay Area's recipe for achievement, but we cannot rest on our laurels. As we head into the election, private and non-private sector leaders should work together to make sure our region stays the world's leading hub for innovation.

In the approaching decade, more people will go into space than ever before as human spaceflight enters a brand new era. NASA, the European Space Agency and other government agencies are working together to develop manned missions beyond the moon. At the identical time, these agencies are working with private corporations which can be using latest technologies to scale back the fee of space exploration.

Companies like SpaceX, Blue Origin and Sierra Space have developed vehicles with reusable boosters, automated flight systems and light-weight materials to Support these space missionsSome even have their very own ambitions to construct private space stations, moon bases or mining corporations in the approaching many years.

But while these technologies and partnerships are rapidly making space travel more accessible, also they are creating latest challenges. One of them is maintaining the health and performance of an astronaut crew. My Team by researchers and educators on the University of Colorado and others around the globe are attempting to unravel this problem.

New medical challenges in space

NASA astronauts are amongst essentially the most successful people on the planet and among the many healthiest. Astronauts undergo extensive medical and psychological testing, which is documented in a study 26% of the finalists were disqualifiedThis rigorous screening and testing process effectively limits the likelihood of a medical incident during a deployment.

But as space travel becomes more cost-effective, astronaut crews on industrial missions will likely make up the vast majority of space travelers in the approaching years. Private missions might be short and can remain in close orbit across the Earth within the near future, but private crews will probably less training and more chronic diseases than the skilled astronauts who currently live and work in space.

While Experiments on board the International Space Station Although the traditional physiological changes of the human organism in microgravity have been extensively studied, there is restricted to no data on how common chronic diseases similar to diabetes or hypertension behave within the space environment.

This industry boom also creates opportunities for long-term missions to the Moon and Mars. Due to the length of the missions and the gap from Earth, skilled Astronauts on these missions will experience prolonged weightlessness, resulting in bone and muscle atrophy, communication delays of a number of seconds to 40 minutes, and extreme isolation lasting months to years.

The crews must operate autonomously and are exposed to latest dangers similar to lunar or Martian dust. Due to the fuel required for these missions, resources are limited to the smallest possible mass and volume.

As a result, mission planners must make difficult decisions to find out upfront what supplies are really vital, as resupply options for food, water and medicine are limited or unavailable. In space, for instance, radiation and moisture inside a spacecraft can Medications worsen faster and change into unavailable to crew members and even toxic.

The crews of the space station have Access to an aviation doctor within the mission control center to administer medical care in the identical way that telemedicine is used on Earth. However, crews on distant planets might want to perform medical care or procedures autonomously.

In the event of a medical emergency, crews may not have the ability to evacuate to Earth. Unlike the space station, where medical evacuations to Earth can happen in lower than 24 hours, Lunar evacuations can take weeksEvacuations from Mars will not be possible for months and even years.

In short, current approaches to medical care in space don’t meet the needs of future industrial and skilled astronauts. Researchers must develop latest technologies and novel training approaches to organize future personnel to treat medical problems in space.

The current leaders in space medicine are experts in either aerospace engineering or medicine, but rarely have they got formal training or extensive knowledge in either field. And often these disciplines cannot speak one another's language, literally or figuratively.

Training the following generation

To meet the increasing demands of manned space flight, educators and universities are attempting to develop a way to coach specialists who understand each the bounds of the human body and the constraints of engineering design.

Some schools and hospitals, similar to the University of Texas Medical Schooloffer continuing teaching programs for medical graduates in aerospace medicine. Others, like UCLA And Massachusetts General Hospitalhave special training programs in space medicine, that are currently aimed toward fully trained emergency physicians.

My team on the University of Colorado has developed a program that integrates human physiology and engineering principles to coach medical students to think like engineers.

This program The aim is to assist students understand human health and performance within the space environment. It addresses these topics from a Engineering Design and constraints to seek out solutions to the challenges faced by astronauts.

One of our hottest courses is known as Mars in simulated surface environments. In this course, students might be exposed to engineering and medical scenarios in a simulated Mars environment within the Utah desert. Students might be required to grapple with the challenges of working and providing care in a spacesuit and in a desolate, Mars-like landscape.

The stress of the simulations can seem real to students they usually learn to make use of their combined skills to take care of their fellow crew members.

Educational programs like these and others aim to provide cross-disciplinary specialists who’re well versed in each patient care and engineering design practices and who can mix the 2, whether for space tourists in orbit or as pioneers on the surface of one other planet.

A brand new era of space travel has begun and these programs are already training experts to create space accessible and secure.

Why is it so hard to persuade even when you’ve got facts in your side?

As a philosopherI'm particularly focused on persuasion – not only tips on how to persuade someone, but in addition tips on how to do it ethically and without manipulation. I discovered that one of the profound insights comes from the German philosopher Immanuel Kant: a spotlight from my researchwho was born 300 years ago: April 22, 1724.

In his last book on ethics: “The doctrine of virtue“Kant writes that each of us has a certain duty when we try to correct the beliefs of others.” If we expect they’re unsuitable, we should always not dismiss them as “absurdity” or “poor judgment,” he says , but must assume that their views “contain some truth.”

What Kant describes may sound like humility – simply acknowledging that other people often know things we don't. But it goes beyond that.

This moral duty to search out the reality within the mistakes of others is predicated on helping the opposite.”maintain one's respect for one's own understanding” Kant claims. In other words, even once we encounter clearly false points of view, morality requires us to assist the person we’re talking to keep up their self-respect – that’s, to search out something reasonable of their views.

This advice can seem condescending, as if we should always treat other adults like children with fragile egos. But I believe Kant made something essential here, and contemporary psychology can assist us see it.

The need for respect

Imagine having to postpone lunch due to a gathering. With only quarter-hour to spare and a growling stomach, you head out to grab a burrito.

However, in your way you meet a colleague. “I’m glad to see you,” they are saying. “I hope that the meeting will help you change your mind.”

In this scenario, your colleague has little probability of convincing you. Why? Well, you would like food, and so they get in the way in which of satisfying that need.

As Psychologists of persuasion We have long recognized that spotlight is a key consider persuasion, and that folks don’t care about persuasive arguments once they have more pressing needs – particularly hunger, sleep and safety. But less obvious needs can even make people unconvincable.

One that has attracted quite a lot of attention in the previous few a long time is the necessity for social belonging.

Psychologist Dan Kahan gives the instance of somebody who, like everyone in his community, falsely denies the existence of climate change. If this person publicly corrects their beliefs, they might be ostracized by family and friends. In this case, Kahan suggestsIt could also be “totally rational” for them to easily ignore the scientific evidence on a subject over which they don’t have any direct influence as a way to satisfy their social need for connection.

This signifies that a respectful persuader must consider others' needs for social dignity, for instance by avoiding public places when discussing topics that may be sensitive or taboo.

… and self-respect

But it's not only external needs equivalent to hunger or social acceptance that stand in the way in which of conviction. In a classic 1988 article about self-affirmation, the psychologist Claude Steele argued that our desire to keep up a certain “self-esteem” as , competent human being profoundly shapes psychology.

More philosophically, people have a necessity for self-esteem. For example, this may explain why students sometimes attribute bad grades to bad luck and difficult material, but attribute good grades to: their very own abilities and efforts.

Steele's approach has produced some surprising results. For example, a study encouraged female students to jot down down values ​​that were essential to them—an exercise in self-affirmation. Afterwards, many students who did this exercise achieved higher grades in a physics course, especially girls who had previously performed worse than male students.

This study and lots of others Illustrate how strengthening an individual's self-esteem can enable them to beat mental challenges, including challenges to their personal beliefs.

With this in mind, allow us to turn back to Kant.

Politics is something personal

Recall Kant's claim: When we encounter someone with false beliefs, even absurdly false ones, we must help them maintain respect for their very own understanding by recognizing a component of truth of their judgments. This truth might be a fact we had missed or a vital experience that they had had.

Kant doesn't just discuss modesty or politeness. It draws attention to an actual human need—a necessity that persuaders must recognize in the event that they are to realize a good hearing.

Say you should change your cousin's mind about who he should support within the 2024 election. They have well-developed evidence and thoroughly select an appropriate time for a face-to-face interview.

Despite all this, in the event you ignore your cousin's need for self-respect, your chances are high slim. In a rustic as polarized because the United States today, an argument over who to vote for can feel like a direct attack on an individual's competence and moral decency.

So giving someone evidence that they need to change their views can run directly into their need for self-esteem – our human have to see ourselves as intelligent and good.

Moral maturity

In other words, persuasion requires quite a lot of juggling: A persuader must not only make convincing arguments but in addition avoid threatening the opposite person's need for self-respect.

The actual juggling can be much easier if we could decelerate the objects. This is what juggling on the moon is all about twice as easy like on Earth, due to the moon's lower gravity.

However, relating to persuasion, we are able to slow things down by speeding up the conversation, thereby gaining time to learn something from the opposite person in return. This signals that you just are taking them seriously – and that may boost their self-esteem.

To be ethical, this openness to learning should be sincere. But it's not difficult: each of us has limited experience on most topics. Maybe Donald Trump or Joe Biden, for instance, have validated a few of your cousin's frustrations with their local government in ways you couldn't have imagined.

This approach also has a vital profit for you: it helps you maintain your personal self-respect. Ultimately, dealing humbly with others shows moral maturity. When you recognize others' need for self-esteem, you possibly can not only persuade someone, but achieve this in a way which you can be happy with.