Almost half of all dementia cases might be delayed or prevented by considering 14 possible risk aspects, including vision loss and high cholesterol.

That means crucial results of a brand new study which we and our colleagues published within the journal The Lancet.

dementiaa rapidly growing global challenge, affects an estimated 57 million people worldwide, and this number is anticipated to rise to 153 million by 2050 worldwide. Although the Dementia is on the decline In high-income countries, it stays Increase in low- and middle-income countries.

This third updated report of the Lancet Commission on Dementia comprises excellent news and a robust message: politicians, clinicians, individuals and families can take ambitious motion to forestall and reduce the danger of dementia and improve the standard of lifetime of individuals with dementia and their caregivers through evidence-based approaches.

The latest report confirms 12 potentially modifiable risk aspects already identified in two previous reports. published in 2017 And 2020It also provides latest evidence for 2 other modifiable risk aspects: vision loss and high levels of low-density lipoprotein (LDL) cholesterolsometimes called “bad” cholesterol.

Our review of the published evidence found that addressing 14 modifiable risk aspects could reduce the prevalence of dementia by 45% globally. Even greater risk reductions could also be possible in low- and middle-income countries, and for low-income people in higher-income countries, given higher prevalence of dementiahealth inequalities and risk aspects in these populations.

The report also suggests that reducing these 14 risks can increase the variety of healthy years of life and reduce the time spent in sick health in individuals with dementia.

In addition, the report cites clinical studies showing that non-pharmacological approaches, reminiscent of using activities tailored to interests and talents, Reduce dementia-related symptoms and improve quality of life.

We are a General internist and a Applied sociologist and intervention scientistand our work focuses on memory and well-being in older adults. Together with 25 other internationally recognized dementia experts under the leadership of psychiatry professor Gill Livingston, Research Associatewe fastidiously reviewed the evidence to derive recommendations for prevention, intervention and care.

Why it’s important

The rapid growth of the world’s ageing population is a triumph of higher public and private health across the lifespan. But given the shortage of a cure for dementia, that is Report highlights the importance of prevention and to enhance the standard of life of individuals diagnosed with dementia.

In the brand new report, our team proposed an ambitious dementia prevention programme that might be implemented at individual, community and policy levels and across the lifespan from early to middle and late life. The key points are:

• Improving general education at a young age.
• In midlife: Treatment of hearing loss, high LDL cholesterol, depression, traumatic brain injury, physical inactivity, diabetes, smoking, hypertension, obesity, and excessive alcohol consumption.
• In later life, social isolation, air pollution and vision loss decrease.

Taken together, these aspects result in the Lancet Commission on Dementia's estimate that dementia risk will be reduced by 45%. And a wealth of latest research shows that tackling risk aspects reminiscent of exposure to air pollution is linked to: improved cognition and sure reduction in dementia risk.

New evidence supports the concept in high-income countries, reducing the danger of dementia may translate into more healthy years, years freed from dementia, and shorter disease duration in individuals who develop dementia.

What just isn’t yet known

The 45% reduction in the danger of dementia in the worldwide population is predicated on a calculation that assumes that risk aspects are causal and will be eliminated. It shows the importance of dementia prevention and the impact it will have on individuals and families.

The Commission stressed that more research is required to discover additional risk aspects, examine changes in risk aspects in clinical trials, provide guidance for public health efforts, and discover and evaluate strategies for implementing and scaling up evidence-based programs to support individuals with dementia and their caregivers.

The updated report has global public health and research implications and will likely be widely shared, guiding clinicians and policymakers and outlining latest research directions.

The Research Brief is a summary of interesting scientific papers.

SANTA CLARA – The 49ers will go 14-3 this regular season. Yes, that's the prediction resulting in a Super Bowl return in New Orleans, where they'll beat Jim Harbaugh's Los Angeles Chargers.

Too far-fetched? Look, the 49ers went 12-5 last yr, 13-4 in 2022, they usually've posted double-digit wins in 4 of the last five seasons.

Their roster remains to be stacked (for at the very least one other season), especially on offense. They have a Pro Bowl quarterback (Brock Purdy), their backfield has the 2023 NFL rushing king (Christian McCaffrey), the three-time All-Pro left tackle (Trent Williams) is just not yet retired, their tight end (George Kittle) reclaimed first-team All-Pro honors in a yr where Travis Kelce was within the highlight, and all of their wide receivers have something to prove.

This talented team scored just 22 points – 19 in regulation – and that wasn't enough to dethrone the Kansas City Chiefs within the Super Bowl.

The Detroit Lions' return to motion on Dec. 30 at Levi's Stadium could definitely have serious implications for the playoffs, wherein the 49ers swept the Lions to win the NFC Championship last season.

And every division game carries added weight, however the NFC West has yet to catch as much as the two-time reigning champion 49ers.

That said, listed here are the five games which might be most dangerous to the 49ers' path, and I expect them to lose two of them and one other somewhere along the way in which:

Week 2 in Minnesota: The 49ers have lost their last seven visits to Minnesota, including a 22-17 loss last season. Go back to December 1992 and find the 49ers' last win there, when Amp Lee scored her two touchdowns in a 20-17 victory. Sam Darnold, the Vikings' projected starter until JJ McCarthy is prepared, knows the 49ers' defensive system intimately after combating it as a scout team quarterback last season. It's a ten a.m. PT kickoff.

Week 7 vs. Kansas City: Andy Reid, Patrick Mahomes, Travis Kelce and Chris Jones have a 4-0 record against the 49ers, including Super Bowl wins within the 2019 and '23 seasons and a Week 7 win at Levi's Stadium in 2022. The Chiefs will his coming from her farewell. Reid shines after a bye.

Week 8 vs. Dallas: This disappointment comes after the sport against the Chiefs, be it one other demoralizing defeat or an emotional triumph. A loss here would impact the NFC playoff picture. The Cowboys may even say goodbye.

Week 13 at Buffalo: No game presents a greater challenge in inclement weather than a December 1 visit to Orchard Park, NY, with kickoff at 8:20 p.m. ET. The 49ers are 2-3 all-time in Buffalo. On their last visit in 2016, as a part of the pre-Shanahan team, they fell 2-14 in a 45-16 defeat. This is just not a take: The Bills will likely be saying goodbye.

Week 17 in Detroit: Last Sunday's win in Miami may very well be more discouraging by way of a possible trap game if the 49ers' cross-country thoughts are sapped by the following rematch with the Lions. Plus, the 49ers may very well be poisoned by chasing the speedy Dolphins. Still, Detroit's expected addition to last season's upwardly mobile numbers will once more give the 49ers their best competition for the NFC crown. What could go incorrect at a prime-time home game in December?