Celebrities born on at the present time: Mo'Nique, 57; Gary Dourdann, 58; Jermaine Jackson, 70; Bess Armstrong, 71.

Happy Birthday: Test yourself, do the legwork, and train your mind to determine what matters most and tips on how to put your life on a quick track to achieving your goals and finding happiness . It's as much as you to regulate what you suspect and the way you implement it. A passionate approach to creating a living and using your money to make sure comfort and peace of mind is in your best interest. Their numbers are 8, 14, 24, 27, 31, 38, 47.

Aries (March 21-April 19): Listen fastidiously and evaluate situations. Learn all the pieces you possibly can, review what you've discovered, revise your goals, and design a plan to remain on top of things while constructing a solid financial foundation. Attend events that interest you and expand your circle of friends. Romance is written in the celebrities. 3 stars

TAURUS (April 20-May 20): Emotional situations will escalate quickly. 'Tis the time to be kind, generous and forgiving, so avoid moving into an argument or a no-win situation. Protect your relationships from outside influences that put pressure on you or your family members. Pay attention to the value tags and avoid overspending. Channel your energy correctly. 3 stars

GEMINI (May 21-June 20): You could have many options, but not all of them will likely be in your best interest. Think about what is essential and the way you possibly can profit from your money, time and skills. Charm, interest in what others are doing and using your intelligence to market your vision can pay off. 3 stars

CANCER (June 21-July 22): Walk the walk and use your skills to face out from those that need to compete with you. Showing compassion or being careless can cost you dearly if you happen to don't know the facts before speaking up for another person. Avoid dangerous situations. 4 stars

LEO (July 23-August 22): Avoid getting caught up within the hustle and bustle that the festive season inevitably brings. Take a moment to breathe deeply, consider your strategy, and plan your day accordingly. Your goal needs to be to assist others during this busy time of 12 months and ease the burden of shopping for love with lavish gifts. 2 stars

VIRGO (August 23-September 22): Situations escalate quickly when someone near you overreacts, spends money, or indulges in unhealthy ways. Set boundaries and set a very good example along with your actions and invitations to take part in healthy activities and smart lifestyle decisions. The best solution to impress someone is with charm. 5 stars

LIBRA (Sept. 23-Oct. 22): Traveling, attending gatherings, or arranging your space for upcoming festivities stimulates your mind and promotes positive personal changes that improve your appearance and attractiveness. Someone out of your past will influence the way you improve your profile or lifestyle. Discover the probabilities. Love is written in the celebrities. 3 stars

SCORPIO (Oct. 23-Nov. 21): Your actions won’t go unnoticed. Be fair and honest and keep your guarantees to avoid upsetting someone you’re keen on or rely on for help. Rely in your creative imagination and use all the pieces at your disposal to brighten your surroundings and reflect this time of 12 months. 3 stars

SAGITTARIUS (November 22-December 21): Fire anyone who meddles in your affairs or limits your options. Be careful the way you present your ideas and develop your skills. Keep in mind what's trending, but refuse to purchase into an idea or plan that may profit another person greater than yourself. Make fitness a priority. 5 stars

CAPRICORN (December 22-January 19): Intelligence and charm show you how to move forward with fewer disruptions. Pay attention to what others are going through while offering kindness and easy solutions. You will receive a favor in return. A mysterious approach to home changes will show you how to achieve your goal. Avoid attending events that pose a health risk. 2 stars

AQUARIUS (January 20-February 18): Dodge a bullet and avoid situations that promote emotional chaos. Set your sights on changes you possibly can implement that may make life more enjoyable and soften the personalities of those you encounter each day. When you retain the peace, you encourage others to step in and help fairly than get in your way. 4 stars

PISCES (February 19-March 20): Obtain information fastidiously and share only verified information. Examine your options and take into consideration how you need to use your skills to do something that you think that is more exciting or lucrative. Be careful to not let your emotions get the higher of you with regards to money matters or attempting to buy love. 4 stars

Birthday Girl: You are energetic, playful and brave. They are resourceful and disciplined.

1 star: avoid conflict; Work behind the scenes. 2 stars: You can achieve something, but don't depend on others. 3 stars: Focus and you may achieve your goals. 4 stars: High goals; start latest projects. 5 stars: Nothing can stop you; Get gold.

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STOCKHOLM – Two scientists have won Nobel Prize in Physiology or Medicine on Monday for his or her discovery of microRNA, tiny pieces of genetic material that function on-and-off switches in cells and help control what the cells do and after they do it.

If scientists higher understand how they work and how one can manipulate them, it could in the future result in effective treatments for diseases like cancer.

The work is by Americans Victor Ambros and Berkeley natives Gary Ruvkun “proves to be of fundamental importance for the development and function of organisms,” said a panel that awarded the prize in Stockholm.

Ambros and Ruvkun were initially considering genes that control the timing of varied genetic developments, ensuring that cell types develop at the correct time.

Their discovery ultimately revealed “a new dimension of gene regulation that is essential for all complex life forms,” the panel said.

What is the Nobel Prize for?

RNA is best known for passing instructions for making proteins from DNA within the cell nucleus to tiny cell factories that truly construct the proteins. MicroRNA doesn't produce proteins, but it surely helps control what cells do, including turning on and off critical genes that make proteins.

Last 12 months's Nobel Prize in Medicine went to scientists who discovered how one can manipulate one in every of all these RNA, called messenger RNA or mRNA, which is now used to make vaccines against COVID-19.

Ambros and Ruvkun's revolutionary discovery was first made on worms; They wanted to search out out why some sorts of cells didn’t evolve in two mutant worm strains commonly utilized in science as a research model.

“Their groundbreaking discovery revealed an entirely new principle of gene regulation that proved essential for multicellular organisms, including humans,” says the citation, explaining the importance of their work.

This mechanism has been at work for a whole bunch of hundreds of thousands of years and has enabled the event of complex organisms, it said.

Ambros, currently a professor of natural sciences on the University of Massachusetts Medical School, conducted the research at Harvard University. Ruvkun's research was conducted at Massachusetts General Hospital and Harvard Medical School, where he’s a professor of genetics.

Why is microRNA vital?

Fletcher said there are two principal areas where microRNA might be helpful: in developing drugs to treat diseases and as possible indicators of disease by tracking microRNA levels within the body.

“If we take the example of cancer, we have a particular gene that is working overtime, it could be mutated and working at full speed,” Fletcher said. She said scientists may in the future find a way to make use of microRNA to stop such effects.

Eric Miska, a geneticist on the University of Cambridge, said Ambros and Ruvkun's discovery was an entire surprise and upended what scientists had long understood about how cells work.

Their discovery of microRNA shocked many scientists, Miska said, explaining that such small pieces of genetic material had never been seen before. It later emerged that the tiny RNA fragments – the human genome has no less than 800 – play a vital role in the event of our bodies.

Miska said that work is currently underway on the role of microRNA in infectious diseases comparable to hepatitis and that it may be helpful in treating neurological diseases.

Fletcher said essentially the most advanced studies up to now are examining how microRNA approaches could help treat skin cancer, but no drugs have been approved yet. She predicted this might occur in the approaching years, adding that almost all treatments currently goal cellular proteins.

“If we can intervene at the microRNA level, it opens up a whole new opportunity for us to develop drugs,” she said.

How did Gary Ruvkun and Victor Ambros react?

The call from the Nobel Prize panel is usually a surprise, but there are specific signs that recipients and their families notice.

“Well, when a phone rings at 4:30 in the morning. … That never happens here,” Ruvkun said.

“Natasha actually responded,” Ruvkun added, referring to his wife. “And she says, 'He has a Swedish accent.'”

It took just a little longer to wake Ambros.

“Someone called my son, who called my wife because my phone was downstairs,” he said.

Ruvkun immediately knew the impact the award would have on his life.

“Well, I kept repeating it in my head, this changes everything because the Nobel Prize is just mythical when it comes to how it changes the lives of the people chosen,” Ruvkun said. “The Nobel Prize is a recognition that generates about 100 times as much press and cheers as any other award. So it's not part of a continuum. It’s a quantum leap.”

Accepting his award in December might be the third time he has attended a Nobel ceremony in Stockholm, having watched his mentor Robert Horvitz in 2002 and his 2009 winning pal Jack Szostak.

“A journey is coming. It will be the third, possibly the best,” Ruvkun said.

Ambros said he didn’t expect the award because he believed the Nobel Committee had already highlighted RNA within the 2006 prize, which went to his friends Andrew Fire and Craig Mello.

“It represents a recognition of how wonderful and unexpected discoveries arise from a curiosity in basic research funded by taxpayer dollars.” “It's an extremely important message, probably the most important message, that this investment is really paying off,” he said.

Last 12 months, The Nobel Prize in Physiology or Medicine went to Hungarian-American Katalin Karikó and American Drew Weissman for discoveries that enabled the event of mRNA vaccines against COVID-19, which were crucial to slowing the pandemic.

The price is endowed with a money prize of 11 million Swedish crowns ($1 million) from a bequest from the prize's initiator, the Swedish inventor Alfred Nobel.

The Nobel announcements proceed with the Physics Prize on Tuesday, the Chemistry Prize on Wednesday and the Literature Prize on Thursday. The Nobel Peace Prize might be announced on Friday and the Nobel Prize in Economic Sciences on October 14th.

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This story has been updated to make clear that microRNA helps regulate gene activity slightly than containing instructions for making proteins.

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Corder reported from The Hague, Netherlands, Cheng reported from London. Associated Press journalists Steven Senne and Rodrique Ngowi in Newton, Massachusetts, and Adithi Ramakrishnan in New York.

Originally published: October 7, 2024 at 10:24 am

Harry Kane responded to Gary Lineker's criticism of England's Euro 2024 campaign by saying that former internationals have a “responsibility” to reflect on the impact of their words.

England got here under scrutiny after a 1-1 draw with Denmark of their second group match at Euro 2024, with former striker Lineker branding the performance “shit”.

Kane said while he understood that pundits had an obligation to be honest, he added that former players should pay attention to the challenges involved in representing England given the country's historic and ongoing failures at major tournaments.

Asked specifically about Lineker's comments, Kane replied: “Former players have to be aware that it is very difficult not to listen to it these days, especially for some players who are not used to it or who are new to the environment.”

“I always feel they have a responsibility. I know they have to be honest and give their opinion, but they also have a responsibility as a former England player who many players looked up to. People are interested in what they say and people listen to them.

“Everyone has their very own opinion but the underside line is that we haven't won anything as a nation for a really, very very long time and a number of these players were involved in that too, in order that they know the way tough it’s.

“It's not about eliminating anyone. It's just the fact that they know it's tough to play in these big tournaments and tough to play for England.”

“I would never disrespect a player. I would just say: remember what it's like to wear that jersey and that his words are listened to. They are heard.

“We all need to win a giant tournament. If we help them as much as we will and provides them confidence, that's a significantly better way.”

Lineker, 63, scored 48 goals in 80 appearances for England between 1984 and 1992. He won the Golden Boot at the 1986 World Cup and was part of the England team that reached the semi-finals of the 1990 European Championships in Italy.

After England’s draw with Denmark, Lineker told the Rest is football podcast: “I believe we want to reflect the mood of the nation. I can't imagine that anyone who’s English would have enjoyed that performance since it was lethargic, it was grim. You can think up all kinds of words and swear words if you happen to want, but it surely was shit.”

Kane scored his first goal of the European Championship against Denmark, but admitted that he had been out of form personally in the first two games.

“I attempt to steer clear of it (watching and reading media criticism) as much as possible,” he added. “I believe it's almost unattainable lately with all the several platforms to not see some things.”

“As a player, everyone has the correct to their very own opinion and I do know that in big tournaments all the pieces gets more exciting and performance is scrutinised. If I'm honest with myself… did I do my best? No.

“But I didn't score a goal in the group stage of the World Cup or the group stage of the European Championship. So from my point of view, being one goal ahead is a bonus. I always judge myself first and I know I can play better and I know a lot of players in the team think that too – that we can all play a little bit better. That's what I do. I don't panic. I don't get too elated or too depressed. I keep doing what I'm doing and just move on to the next game.”

Kane was substituted within the second half of England's draw with Denmark after missing the tip of Germany's season with a back injury.

Although there have been concerns concerning the 30-year-old's fitness, he stressed that he felt fresh and had no injury worries.

“I think the preparation for the tournament was good for me personally,” said Kane. “Even in the matches of the tournament, in the first game, I felt as fit as I have all season. Of course I know that I was substituted in the second game, but that was because the coach wanted to see something different, maybe especially to freshen up the strikers.”

“In my opinion, I am fit and I am getting better and fitter with every game. I have said the same thing in previous tournaments, that you have to try to be at your best when the most important part of the tournament comes, the knockout round.

“As at all times, time will tell. If we’re eliminated, there might be a number of questions, but from my standpoint, I believe that going into that knockout round, you’re feeling 100% comfortable (that's necessary) and I believe I'm there.”

Gareth Southgate's side are preparing for their final Group C game against Slovenia on Tuesday, currently leading the table with four points.

After the draw with Denmark, Southgate said England were not physically at the “right” side to apply pressure high up the pitch.

Kane said England's pressing problems stemmed from playing against a back three against Serbia and Denmark. Slovenia played with a back four in their first two group matches and the England captain said he hoped his side could be more forceful.

“I believe each games against the three-man defense left us a bit confused on the pitch,” he said. “We had prepared before the sport. But then there have been just certain things where we couldn't quite construct up the pressure that we desired to and we weren't 100% sure when to go and that's difficult.”

“I don't think we were good with the ball, which made it feel like we were just running and continuously running. So it was difficult to reverse that momentum. I believe in the subsequent game it’ll be a special threat due to lineup… it’ll probably be different than in Slovenia. Hopefully we will show a bit more energy and enthusiasm, especially without the ball, and I believe that may help us with the ball as well.”

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What we learned from Kane's expressive performance

Harry Kane entered the English media room at Blankenhain Castle, won a darts match, sat down, answered questions, took a sip of water and then left the room.

But the part in between, in which the English captain spent 40 minutes clarifying things from the camp's point of view, was unusually revealing.

It was decided on Sunday morning that Kane would be the player to speak at the public press conference. This is part of a wider strategy by the Football Association regarding which voices are heard and at what time, and Kane is more than happy to take on that responsibility.

analyzed what he said and what it meant

England's critics

“The bottom line is that we haven't won anything as a nation for a really, very very long time and a number of these players have been involved in that. They know the way tough it’s,” Kane said in reference to Lineker's dig.

Lineker was not the only pundit to criticise England's performance against Denmark, but as the face of Britain's national broadcaster's football coverage, his words carry more weight than most.

Although Kane remained respectful and raised several reservations, he clearly wanted to stand up for the team after the negative reaction to them.

His own fitness

“I felt fitter than I actually have all season. I do know I used to be substituted within the second game, but that was since the coach desired to see something different and clean up the strikers. It's necessary to enter this knockout round feeling 100% and I believe I'm there.”

Kane was quick to dismiss the notion that he was not fully fit, having missed Bayern Munich's final game of the season due to a back injury.

He looked underwhelmed in England's first two games at Euro 2024, but tried to reassure his fans by telling them not to worry about his fitness.

Tactical problems within the opening games

“I just think playing against the back three in both games caused us a little bit of confusion on the pitch. We had prepared before the game. But then there were just certain things where we couldn't quite build the pressure that we wanted to and we weren't 100 percent sure when to go and that's difficult.”

After the Denmark game, Kane said the players didn't know when to use pressure. It was a devastating revelation. And now he has provided that assessment a bit more context, mentioning that playing against a back three disrupted attacking triggers. Playing against Slovenia's likely back 4 should alleviate that problem.

keep Calm and carry on

“I think we are calm. Many of us have been here and done it and we have given the English fans some fantastic moments. I know that 99 percent (of the fans) are fully behind us. You can judge us after the tournament.”

The word “calm” was utilized by Kane 3 times during his press conferences and in as many answers.

The message from England's training camp after the Denmark game is that the team remain relaxed – or at the very least attempt to – despite the dismal performances. Kane reiterated that message on Sunday, urging fans to order their final judgement until the tip of the Three Lions tournament.