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	<title>differently &#8211; USA NEWS LIVE</title>
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	<title>differently &#8211; USA NEWS LIVE</title>
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		<title>National Politics &#124; The Republicans once wanted the federal government outside of the healthcare system. Trump voters see it otherwise</title>
		<link>https://bloggingthree.soflytech.com/2025/03/national-politics-the-republicans-once-wanted-the-federal-government-outside-of-the-healthcare-system-trump-voters-see-it-otherwise/</link>
					<comments>https://bloggingthree.soflytech.com/2025/03/national-politics-the-republicans-once-wanted-the-federal-government-outside-of-the-healthcare-system-trump-voters-see-it-otherwise/#respond</comments>
		
		<dc:creator><![CDATA[enzo2go]]></dc:creator>
		<pubDate>Wed, 05 Mar 2025 13:03:12 +0000</pubDate>
				<category><![CDATA[Health]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=25680</guid>

					<description><![CDATA[By Noam N. Levey, Kff Health News How many Americans who voted for Donald Trump hopes that Jason Rouse hopes that President&#39;s return will mean lower prices for gas, food and other essential foundations. But Rouse looks into the federal government for relief from a certain pain point: high health costs. &#8220;The prices are just [&#8230;]]]></description>
										<content:encoded><![CDATA[<p><img decoding="async" src="https://www.mercurynews.com/wp-content/uploads/2025/03/202503030400MCT_____PHOTO____US-NEWS-HEALTH-TRUMP-VOTERS-MCT.jpg?w=1400px&amp;strip=all" /></p>
<div>
<p><strong>By Noam N. Levey, Kff Health News</strong></p>
<p>How many Americans who voted for Donald Trump hopes that Jason Rouse hopes that President&#39;s return will mean lower prices for gas, food and other essential foundations.</p>
<aside class="related left"></aside>
<p>But Rouse looks into the federal government for relief from a certain pain point: high health costs. &#8220;The prices are just ridiculous,&#8221; said Rouse, 53, a retired firefighter and paramedic in Michigan, who voted 3 times for Trump. &#8220;I would like to see a lower cap on what I have to pay out of my own pocket.&#8221;</p>
<p>The regulation of state regulation of health prices was formerly heresy for many Republicans. The GOP leaders strongly rejected the 2010 Affordable Care Act, which included the federal government&#39;s costs for the prices of the patients. Recently, the party fought against laws signed by the previous President Joe Biden to limit prescription medication prices.</p>
<p>But when Trump begins his second term, most of the voters who&#8217;ve sent him back to the White House greet more robust measures from the federal government to contain a health system that many Americans perceive uncontrolled, as surveys show.</p>
<p>&#8220;This idea that the government should simply keep its hands away, even if things are difficult for humans, has lost its shine&#8221; <a href="https://publicagenda.org/resource/esi-2024/">Public settings</a> About government and health care.</p>
<p>&#8220;We hike all over the country with a series of old, outdated framework conditions about what ordinary Democrats and ordinary Republicans like,&#8221; he said.</p>
<p>The Republican voters are emphasizing the federal borders of the costs accused by pharmaceutical corporations and hospitals, limits the medical bills of patients and restrictions on how health service providers can pursue people on account of medical debt.</p>
<p>Even Medicaid, the state insurance program, which republican congress manager dramatically perform, is <a href="https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-public-weighs-health-care-spending-and-other-priorities-for-incoming-administration/">inexpensive</a> From many GOP voters like Ashley Williamson.</p>
<p>Williamson, 37, mother of 5 years in Eastern Tene nesse, who voted for Trump, said that Medicaid had provided critical support when her mother-in-law had take care of home care. &#8220;We couldn&#39;t take care of them,&#8221; said Williamson. &#8220;It occurred. It was certain that she implemented herself.&#8221;</p>
<p>Williamson, whose circle of relatives is reported on her husband&#39;s employer, said that she would very much care for large cuts in Medicaid Finance, which could endanger the reporting for needy Americans.</p>
<p>For years, republican ideas for health care have been reflected in broad skepticism for the federal government and fears that the federal government would threaten patients access to doctors or life -saving drugs.</p>
<p>&#8220;The discussions 10 to 15 years ago were around the election,&#8221; said Christine Matthews, a Republican storm that worked for varied GOP politicians, including the previous governor of Maryland, Larry Hogan. &#8220;Free market, not to have the state border or to take over your health care.&#8221;</p>
<p>Matthews and the opposite encoder manager Mike Perry recently convened and paid for several focus groups with Trump voters, including Rouse and Williamson, who watched KFF Health News.</p>
<p>Skepticism towards the federal government lingered among the many ranked Republicans. And ideas akin to switching all Americans right into a single state health plan that resembles &#8220;Medicare for everyone&#8221; are still non -starters for a lot of GOP voters.</p>
<p>But how tens of million Americans are <a href="https://kffhealthnews.org/diagnosis-debt/">driven in debt</a> After medical bills that they can&#8217;t understand or cannot afford, many rate their tendency to look totally free markets as the federal government, said Bob Ward, whose company Fabrizio Ward asked for Trump&#39;s 2024 campaign.</p>
<p>&#8220;I think most people look at this and say that the market is broken, and that&#39;s why they are ready to enter someone, anyone,&#8221; he said. &#8220;The deck is stacked against people.&#8221;</p>
<p>In A <a href="https://assets.arnoldventures.org/uploads/Arnold-Ventures-Hospital-Prices-Survey.pdf">Recent national survey</a>Fabrizio Ward and Hart Research, who has asked for democratic candidates for a long time, showed that Trump voters were more liable for health insurers, pharmaceutical corporations and hospital systems than the federal government for top health costs.</p>
<p>Sarah Bognaski, 31, an administrative assistant within the state of New York, is one in all the various Trump voters who say that they profit from the healthcare industry. &#8220;I don&#39;t think there is a reason why a large part of the costs should be as high as they are,&#8221; said Bognaski. &#8220;I think it&#39;s only out of pure greed.&#8221;</p>
<p>High health costs have affected Bognaski, which was diagnosed 4 years ago with type -1 -diabetes, an illness that is dependent upon insulin. She said she was able to enter the federal government and limit what patients pay for medicinal products. &#8220;I would like to see more regulation,&#8221; she said.</p>
<p>Charles Milliken, a retired automobile mechanic in West Virginia, who said that he supported Trump since the country &#8220;does not need a businessman, no politician&#8221;, expects the brand new president go further.</p>
<p>&#8220;I think he will set an upper limit for which insurance companies that can calculate doctors, which hospitals can calculate,&#8221; said Milliken, 51, who recently had a heart attack, which led him with greater than 6,000 US dollars in medical debts.</p>
<p>Three quarters of the Trump voters control the state borders, which may reap the benefits of hospitals, as Ward&#39;s surveys have found.</p>
<p>And about half of the Trump voters in a single <a href="https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-public-weighs-health-care-spending-and-other-priorities-for-incoming-administration/">Newer KFF </a><a href="https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-public-weighs-health-care-spending-and-other-priorities-for-incoming-administration/">Opinion poll</a> The recent administration should set a priorities to expand the variety of medicines, the worth of which is set by negotiations between the Federal Medicare program and the pharmaceutical company.</p>
<p>Perry, who has convened dozens of focus groups with the voters about health care in recent times, said that the support for the federal government&#39;s price limit was all of the more remarkable, because the regulation of medical prices isn&#8217;t at the highest of the agenda of most politicians. &#8220;It seems to be like a floor,&#8221; he said. &#8220;You have come to this decision yourself, and not all political decision -makers who lead them there that something has to be done.&#8221;</p>
<p>Other types of state regulation, akin to B. Borders for medical debt collections are much more popular.</p>
<p>About 8 out of 10 Republicans supported an upper limit of two,300 US <a href="https://www.lls.org/sites/default/files/2023-10/Medical%20Debt%20Report.pdf">2023 survey</a> by Perry&#39;s ballot. Perryundem. And 9 out of 10 favored an upper limit for rates of interest that were calculated for medical debts.</p>
<p>&#8220;This is what I would consider from a political perspective as a no-brainer,&#8221; said Ward.</p>
<p>However, the political GOP leaders in Washington have historically showed little interest in state limits for the payment of medical care. And when Trump and his allies begin within the congress with the design of their health agenda, many Republican leaders are more all in favour of the reduction of the federal government than to expand their protection.</p>
<p>&#8220;There is often a massive separation,&#8221; said Ward, &#8220;between what happens in the Caucuses on the Capitol Hill and what happens to family tables all over America.&#8221;</p>
<p>© 2025 Kff Health News. Distributed by Tribune Content Agency, LLC.</p>
<p>Originally published: <time datetime="2025-03-04 11:23:10">March 4, 2025 at 11:23 a.m. PST</time></p>
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<p><em>image credit : www.mercurynews.com</em></p>
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		<title>Homeless service providers could help more people overcome homelessness in the event that they measured success in another way</title>
		<link>https://bloggingthree.soflytech.com/2024/07/homeless-service-providers-could-help-more-people-overcome-homelessness-in-the-event-that-they-measured-success-in-another-way/</link>
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		<dc:creator><![CDATA[enzo2go]]></dc:creator>
		<pubDate>Fri, 26 Jul 2024 09:41:57 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[differently]]></category>
		<category><![CDATA[homeless]]></category>
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		<category><![CDATA[measured]]></category>
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		<category><![CDATA[people]]></category>
		<category><![CDATA[providers]]></category>
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		<category><![CDATA[success]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=10033</guid>

					<description><![CDATA[Homelessness is a serious problem within the United States and it&#8217;s getting worse: A record 650,000 Americans were homeless on a single night in January 2023, in line with the newest report from the U.S. Department of Housing and Urban Development. That&#39;s one in 500 people nationwide. In my state of Georgia, the variety of [&#8230;]]]></description>
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<p>Homelessness is a serious problem within the United States and it&#8217;s getting worse: <a href="https://www.huduser.gov/portal/sites/default/files/pdf/2023-AHAR-Part-1.pdf">A record 650,000 Americans</a> were homeless on a single night in January 2023, in line with the newest report from the U.S. Department of Housing and Urban Development. That&#39;s one in 500 people nationwide.</p>
<p>In my state of Georgia, the variety of homeless people has steadily increased since 2017. By 2022, the variety of homeless people in Georgia who were unsheltered—living on the streets or in cars—surpassed the number of people that had access to emergency shelter. <a href="https://www.dca.ga.gov/node/8473">in line with government information</a>. </p>
<p>The politicians were <a href="https://www.usatoday.com/story/news/politics/2024/04/21/supreme-court-ticketing-cruel-punishment/73405633007/">be careful</a>: Every yr the Federal Government awards <a href="https://www.hud.gov/press/press_releases_media_advisories/hud_no_24_018">Billions in funding</a> to local governments and nonprofits to combat homelessness. But this money was not enough to show the tide. Why?</p>
<p>Homelessness has many complex causes, including <a href="http://socialinnovation.usc.edu/wp-content/uploads/2020/08/Homelessness-and-Employment.pdf">unemployment</a>, <a href="https://www.pewtrusts.org/en/research-and-analysis/articles/2023/08/22/how-housing-costs-drive-levels-of-homelessness">Affordable housing</a> And <a href="https://www.samhsa.gov/blog/addressing-social-determinants-health-among-individuals-experiencing-homelessness">Health problems</a>. But when <a href="https://www.scheller.gatech.edu/directory/faculty/rahmani/index.html">Professor of Operations Management</a>I feel an underestimated problem is the best way homeless service providers &#8211; normally non-profits &#8211; measure success. Too often the system promotes quick fixes over long-term solutions.  </p>
<h2>Nonprofit organizations offer a broad but tenuous safety net</h2>
<p>Across the United States, nonprofit organizations provide a spread of services to the homeless, including shelter, housing, rehabilitation, job training, and counseling. There are <a href="https://www.ibisworld.com/industry-statistics/number-of-businesses/community-housing-homeless-shelters-united-states">greater than 12,000 such</a> Providers across the country, including over 50 within the Atlanta metropolitan area alone.</p>
<p>Homeless service providers, like other nonprofits, often publish metrics as an example their success. This not only helps them gain insight into the effectiveness of their work, but additionally helps them communicate their values ​​to government, donors and the general public.</p>
<p>Homeless service providers often boast about their effectiveness in providing meals, providing beds, or offering classes. <a href="https://doi.org/10.1287/msom.2021.0966">Investigations have shown</a>However, none of those measures reflect success in reducing homelessness.</p>
<p>These are <a href="https://ssir.org/articles/entry/getting_results_outputs_outcomes_impact">Measuring results, not impacts</a>. Outputs are the tangible results of activities, while impact refers to long-term changes and advantages of activities. It is surprisingly rare for homeless service providers to measure impact within the context of reducing homelessness &#8211; that&#8217;s, whether the people they serve have turn out to be independent and not homeless.</p>
<p>This is a mistake. Business research shows that the best way nonprofits measure their success has a direct impact on how they set priorities. Depending on the characteristics of clients and services, homeless service providers may find a way to <a href="https://doi.org/10.1287/msom.2021.0966">achieve greater social impact</a> – in other words, do more good by prioritizing case resolution rates over the variety of clients served.</p>
<p>To be clear, homeless service providers make remarkable contributions to communities across the United States, and I don&#8217;t mean to criticize them. Rather, I do mean to focus on that the sector often focuses on measuring outcomes quite than impacts. This focus, in fact, influences their activities and their ultimate success.</p>
<h2>A greater way for service providers for the homeless</h2>
<p>How can nonprofits measure their impact on homelessness? </p>
<p>They can start by bearing in mind the sustainable advantages of their services, resembling the number of people that have turn out to be self-employed, the common length of rehabilitation, vocational training and job placement, and the starting salary of people that receive job search assistance and subsequently find work.</p>
<p>You can go a step further and consider the share of clients who remained employed for greater than a yr, who were in a position to pay for child custody for greater than a yr, or who weren&#8217;t arrested for greater than a yr after their lawsuit was served.</p>
<p>You may rightly say that it&#8217;s difficult to measure these goals, but some organizations have shown that it is feasible.</p>
<p>For example, <a href="https://georgiaworks.net/about-the-program/">Georgia Works</a> has helped greater than 1,000 people escape homelessness. And when you take a look at their website, you&#39;ll see that they measure their impact by the measures mentioned above. This organization focuses on helping their clients turn out to be independent.</p>
<p>Beyond measuring impact, additionally it is necessary for nonprofits to effectively communicate these actions to funders resembling government agencies and donors. Without clear communication, organizations that focus solely on consequence measures may appear more productive even when their activities wouldn&#8217;t have a sustained impact. This could end in more funding being allocated to those organizations than people who have a more real and sustainable impact. </p>
<p>By prioritizing and standardizing impact metrics and communicating them clearly to funders, Americans can reduce homelessness and construct stronger, more resilient communities.</p>
</p></div>
<p><em>image credit : theconversation.com</em></p>
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		<title>Web shoppers behave in a different way after chatting with employees of the other sex, recent research shows – so firms should concentrate</title>
		<link>https://bloggingthree.soflytech.com/2024/06/web-shoppers-behave-in-a-different-way-after-chatting-with-employees-of-the-other-sex-recent-research-shows-so-firms-should-concentrate/</link>
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		<dc:creator><![CDATA[enzo2go]]></dc:creator>
		<pubDate>Mon, 03 Jun 2024 16:29:41 +0000</pubDate>
				<category><![CDATA[News]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=5268</guid>

					<description><![CDATA[In a digital world where individuals are just pixels on a screen, gender bias can appear in unexpected forms. This is what our research team discovered in a field experiment conducted in the Journal of Operations Management. When individuals are online, anonymity and physical distance encourage them to behave in biased ways. previous work has [&#8230;]]]></description>
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<p>In a digital world where individuals are just pixels on a screen, gender bias can appear in unexpected forms. This is what our research team discovered in a field experiment conducted in <a href="https://doi.org/10.1002/joom.1249">the Journal of Operations Management</a>.</p>
<p>When individuals are online, anonymity and physical distance encourage them to behave in biased ways. <a href="https://journals.sagepub.com/doi/abs/10.1177/10591478241243381">previous work</a> has shown. As professors who study <a href="https://mendoza.nd.edu/mendoza-directory/profile/yoonseock-son/">Business analytics</a>, <a href="https://professor.skku.edu/researcher_eng/professorList.do?mode=view&#038;perId=LZStrFIWwigTAngEgQgFwEoHYQC8DmBZJBmAagAdwEBBAXgqA%20&#038;categoryId=U&#038;jojikCode1=3169&#038;jojikCode2=316901#a">Information systems</a>, <a href="https://mendoza.nd.edu/mendoza-directory/profile/katie-wowak/">Operations management</a> And <a href="https://mendoza.nd.edu/mendoza-directory/profile/corey-angst/">Information technology</a>We wanted to raised understand how gender bias works online. Therefore, we conducted a seven-month experiment with a web-based platform that provides health-related services and products. </p>
<p>The South Korea-based company, whose identity is to be kept secret, sells weight-management products which can be intended to be taken over several weeks. It also provides personalized dietary advice to users based on age, weight, height, lifestyle and other characteristics, and offers one-on-one consultations to reply customers&#39; questions.</p>
<p>We focused on the platform&#39;s chat function, which connects users with paid local advisors who can answer their questions and recommend suitable products. After the exchange, users can rate the advisors. </p>
<p>We found that disclosing an advisor&#39;s gender resulted in clients providing more reviews and better rankings, especially when the advisor is a girl. In addition, opposite-gender client-advisor pairings resulted in higher rankings and stronger engagement than same-gender pairings.</p>
<h2>Why it can be crucial</h2>
<p>Researchers have extensively studied gender bias amongst employers, but bias amongst customers is commonly ignored. Our study delves into this lesser-known territory. </p>
<p>Understanding that gender bias is significant to think about core principles like equality and fairness can also be vital for business reasons. In the service sector, where interaction between employees and customers is essential to success, bias can affect customer satisfaction and ultimately the underside line. The stakes are especially high on online platforms, where matching the suitable service to the suitable user is critical. </p>
<p>When gender influences purchasing decisions, it&#39;s not only a social problem, it&#39;s also a financial one. Companies that successfully mitigate these biases can increase their profits while unlocking the total potential of their customer base. And understanding these biases is step one to addressing them.</p>
<h2>What isn&#8217;t yet known</h2>
<p>Our research suggests that firms can improve customer satisfaction by acknowledging gender bias. To help firms understand and reply to bias, researchers can take several vital approaches. For example, the mechanisms behind gender bias usually are not yet fully understood. It is significant to analyze why customers may respond more positively to advisors of the other sex and to discover the psychological and social aspects that play a job on this.</p>
<p>Researchers also needs to examine racial, cultural and age-related biases, amongst others. Future studies could examine how these biases interact with one another and what combined mitigation strategies could be effective.</p>
<p>The digital revolution has modified the way in which Americans do business, however it has also created recent challenges. One thing is evident: In the digital age, fighting bias isn&#8217;t just an ethical imperative. It is a business necessity.</p>
<p><em>The Research Brief is a summary of interesting scientific papers.</em></p>
</p></div>
<p><em>image credit : theconversation.com</em></p>
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		<title>What&#8217;s metabolism?  A biochemist explains how different people convert energy in another way &#8211; and why that&#039;s vital to your health</title>
		<link>https://bloggingthree.soflytech.com/2024/04/whats-metabolism-a-biochemist-explains-how-different-people-convert-energy-in-another-way-and-why-thats-vital-to-your-health/</link>
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		<dc:creator><![CDATA[enzo2go]]></dc:creator>
		<pubDate>Sun, 28 Apr 2024 23:13:40 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[biochemist]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=1934</guid>

					<description><![CDATA[If you&#39;ve ever scrolled through the health and wellness corners of social media, you&#39;ve probably come across many products that claim to enhance your metabolism. But what exactly is your metabolism? Everything you expose your body to &#8211; from lifestyle to an airborne virus &#8211; affects your physical characteristics like your blood pressure and energy [&#8230;]]]></description>
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<p>If you&#39;ve ever scrolled through the health and wellness corners of social media, you&#39;ve probably come across many products that claim to enhance your metabolism.  But what exactly is your metabolism? </p>
<p>Everything you expose your body to &#8211; from lifestyle to an airborne virus &#8211; affects your physical characteristics like your blood pressure and energy levels.  Together, these biological properties are known as <a href="https://www.genome.gov/genetics-glossary/Phenotype">Your phenotype</a>.  And the biological system, essentially the most direct <a href="https://doi.org/10.1023/A:1013713905833">Influences</a> Your phenotype is your metabolism. </p>
<p>So while you eat something, take medication, smoke, or exercise, your metabolism is chargeable for transmitting that biological information throughout your body so it may well adapt.</p>
<h2>Metabolism is energy conversion</h2>
<p>Your metabolism consists of a <a href="https://biochemical-pathways.com/#/map/1">Network of tens of hundreds of molecules and proteins</a> that convert the food you eat into the energy and constructing blocks your body needs to maneuver, grow, and repair itself.  At the chemical level, energy metabolism begins when the three macronutrients &#8211; carbohydrates, fats and proteins &#8211; are broken down atom by atom to release electrons from chemical bonds.  These electrons charge components in cells <a href="https://www.genome.gov/genetics-glossary/Mitochondria">so-called mitochondria</a>.</p>
<p>Similar to batteries, mitochondria use this electrical potential to generate one other type of chemical energy that the remaining of the cell can use.</p>
<p>Simply put, a significant role of metabolism is to convert chemical energy into electricity and back into chemical energy.  The way wherein this energy is transmitted within the body could play a central role <a href="https://doi.org/10.1093/function/zqac030">whether you might be sick or healthy</a>.</p>
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<div class="placeholder-container" style="--aspect-ratio-percent:77.32095490716179%;--background-color:#ae6e5d"><img decoding="async" alt="Diagram consisting of dense, interconnected multicolored lines and dots" class="lazyload" src="https://images.theconversation.com/files/583577/original/file-20240321-20-vdx8c3.png?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/583577/original/file-20240321-20-vdx8c3.png?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=464&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/583577/original/file-20240321-20-vdx8c3.png?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=464&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/583577/original/file-20240321-20-vdx8c3.png?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=464&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/583577/original/file-20240321-20-vdx8c3.png?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=583&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/583577/original/file-20240321-20-vdx8c3.png?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=583&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/583577/original/file-20240321-20-vdx8c3.png?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=583&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">As this simplified diagram of the human metabolome shows (where lines indicate chemical reactions and dots indicate reactants or products), your metabolic network is incredibly complex.</span><br />
              <span class="attribution"><a class="source" href="https://commons.wikimedia.org/wiki/File:MetabolicNetwork.png">J3D3/Wikimedia Commons</a>, <a class="license" href="http://creativecommons.org/licenses/by-sa/4.0/">CC BY-SA</a></span><br />
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<p><a href="https://scholar.google.com/citations?user=0x0PTVwAAAAJ&#038;hl=en">I&#8217;m a biochemist</a> which studies the various metabolic networks which are used when your body changes.  My team and I were capable of define specific features of metabolism, similar to the presence and amount of certain metabolites &#8211; products resulting from the breakdown of macronutrients &#8211; in quite a lot of diseases.</p>
<p>These diseases include diseases similar to: <a href="https://doi.org/10.3390/cells10092293">COVID-19</a>, <a href="https://doi.org/10.1021/acs.jproteome.3c00070">diabetes</a>, <a href="https://doi.org/10.1016/j.stem.2023.11.001">multiple sclerosis</a> And <a href="https://doi.org/10.3324/haematol.2023.283288">Sickle cell anemia</a>to experience unique environments similar to: <a href="https://doi.org/10.1021/acs.jproteome.1c00912">Radiation exposure</a>, <a href="https://doi.org/10.1126/science.aal0261">High altitude</a>, <a href="https://doi.org/10.1007/s11357-019-00123-w">aging</a> And <a href="https://doi.org/10.1007/s40279-023-01846-9">athletic performance</a>.  Each of those settings influences which parts of your metabolic network are used and the way they impart with one another.</p>
<h2>Top athletes set the upper limits</h2>
<p>In view of the worrying <a href="https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight">Increase in obesity</a> and every part connected with it <a href="https://pubmed.ncbi.nlm.nih.gov/32573660/">Metabolic syndrome</a> – In 2022, about one in eight people around the globe lived with obesity – defining healthy or disordered metabolism may help work out what went unsuitable and how one can address it.</p>
<p>Elite athletes provide a major audience to optimally study metabolic functions, as their network of molecular and chemical reactions have to be fine-tuned to compete on the world stage.</p>
<p>Traditional, <a href="https://doi.org/10.1113/jp279963">Lactate threshold</a> is a vital measure of athletic performance since it determines exercise intensity when lactate begins to rise in muscles and blood.</p>
<p>Contrary to popular belief, lactate isn&#8217;t only a waste product; <a href="https://doi.org/10.1016/j.cmet.2018.03.008">Energy source</a> It also accumulates when it&#8217;s produced faster than the mitochondria can use it.  While a moderately energetic person might reach their exercise threshold at a training intensity of about 2 watts per kilogram, elite cyclists can maintain an intensity of near <a href="https://doi.org/10.1007/s40279-017-0751-x">two to thrice higher</a>.</p>
<p>When we compared the lactate thresholds of a bunch of elite cyclists, we found that the cyclists with higher thresholds had markers of higher mitochondrial function.  One of those markers was <a href="https://doi.org/10.3389/fphys.2020.00578">higher production of coenzyme A</a>a molecule that transports carbon through cells and is very important for breaking down carbohydrates, amino acids and fat into chemical energy.</p>
<p>More powerful cyclists also appeared to do that <a href="https://doi.org/10.1007/s40279-023-01846-9">Burn more fat and burn fat longer</a> during a multi-stage world tour in comparison with less capable cyclists.</p>
<h2>Impaired metabolism in diseases similar to COVID-19</h2>
<p>Your metabolism also changes while you change into sick with an acute illness like COVID-19. </p>
<p>Unlike elite cyclists, COVID-19 patients have one <a href="https://doi.org/10.3390/cells10092293">impaired ability to burn fat</a> that appears to be here to remain <a href="https://doi.org/10.3390/metabo12111026">long COVID</a>.  The blood of those patients at rest is analogous to that of an exhausted elite cyclist.  This suggests that exercise intolerance is common in long COVID <a href="https://doi.org/10.1038/s41467-023-44432-3">mitochondrial dysfunction</a> could play a job in COVID-related fatigue.</p>
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<div class="placeholder-container" style="--aspect-ratio-percent:66.71087533156499%;--background-color:#653a2e"><img decoding="async" alt="Person curled up on a couch, half covered with a blanket" class="lazyload" src="https://images.theconversation.com/files/583585/original/file-20240321-20-nyih40.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;fit=clip" srcset="https://images.theconversation.com/files/583585/original/file-20240321-20-nyih40.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=1 600w, https://images.theconversation.com/files/583585/original/file-20240321-20-nyih40.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=2 1200w, https://images.theconversation.com/files/583585/original/file-20240321-20-nyih40.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=600&#038;h=400&#038;fit=crop&#038;dpr=3 1800w, https://images.theconversation.com/files/583585/original/file-20240321-20-nyih40.jpg?ixlib=rb-4.1.0&#038;q=45&#038;auto=format&#038;w=754&#038;h=503&#038;fit=crop&#038;dpr=1 754w, https://images.theconversation.com/files/583585/original/file-20240321-20-nyih40.jpg?ixlib=rb-4.1.0&#038;q=30&#038;auto=format&#038;w=754&#038;h=503&#038;fit=crop&#038;dpr=2 1508w, https://images.theconversation.com/files/583585/original/file-20240321-20-nyih40.jpg?ixlib=rb-4.1.0&#038;q=15&#038;auto=format&#038;w=754&#038;h=503&#038;fit=crop&#038;dpr=3 2262w" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px"></div><figcaption>
              <span class="caption">Long COVID patients have metabolic profiles just like those of an exhausted elite cyclist.</span><br />
              <span class="attribution"><a class="source" href="https://www.gettyimages.com/detail/photo/worried-young-woman-lying-on-sofa-at-home-royalty-free-image/1366029213">Maria Korneeva/Moment via Getty Images</a></span><br />
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<p>to burn fat <a href="https://www.ncbi.nlm.nih.gov/books/NBK556002/">uses numerous oxygen</a>.  COVID-19 <a href="https://doi.org/10.1021/acs.jproteome.0c00606">damages red blood cells</a> supply the organs with oxygen.  Because red blood cells have one <a href="https://doi.org/10.2450%2F2019.0072-19">limited ability to repair yourself</a>, they could not function as well later of their roughly 120-day lifespan.  This may partly explain why COVID symptoms last so long in some people.</p>
<h2>Blood donors define the center</h2>
<p>Blood transfusions are <a href="https://hcup-us.ahrq.gov/reports/statbriefs/sb149.pdf">one of the crucial common clinical procedures</a>.  Over <a href="https://www.who.int/news-room/facts-in-pictures/detail/blood-transfusion">118 million liters of blood</a> are donated by thousands and thousands of individuals worldwide yearly.  Because blood donors are screened to make sure they&#8217;re healthy enough to donate, they&#8217;re typically moderately healthy, somewhere between acute illness and peak athletic performance.  Blood donor, coming from <a href="https://www.who.int/news-room/fact-sheets/detail/blood-safety-and-availability">every area of ​​life</a>As a study population, additionally they have diverse biological characteristics.</p>
<p>My team and I checked out the blood of over 13,000 blood donors to learn more about their situation <a href="https://doi.org/10.1101/2023.09.11.557250">Metabolic diversity</a>.  We have found specific characteristics that may predict how well a donor&#39;s blood works on patients, which also impacts how well the blood works on the donors themselves.</p>
<p>We found that certainly one of these features is a metabolite <a href="https://doi.org/10.1182/blood.2023022052">called Kynurenine</a>, which is formed when the amino acid tryptophan is broken down.  We found that blood from donors with higher kynurenine levels was less more likely to restore hemoglobin levels in transfusion recipients than donors with lower kynurenine levels. </p>
<p>Kynurenine levels are higher in older donors and donors with a better BMI and will be potentially related to higher levels of inflammation.  Our group also found Kynurenine to support us <a href="https://ash.confex.com/ash/2023/webprogram/Paper187074.html">increases dramatically</a> for runners participating within the 171 kilometer (106 mile) Ultra-Trail du Mont-Blanc.  In addition, we found that kynurenine is a robust marker for <a href="https://doi.org/10.1172/jci.insight.140327">Severity of COVID-19</a>.</p>
<p>The connection between metabolites and health outcomes highlights the vital role metabolism plays within the body.  A greater understanding of what a healthy metabolism looks like can provide unique insights into variations in disease and latest approaches to medical treatments.</p>
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<p><em>image credit : theconversation.com</em></p>
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