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	<title>Breakthrough &#8211; USA NEWS LIVE</title>
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	<description>All About USA NEWS</description>
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	<title>Breakthrough &#8211; USA NEWS LIVE</title>
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		<title>These modern biotech stocks have  probability of constructing a breakthrough in 2025</title>
		<link>https://bloggingthree.soflytech.com/2024/12/these-modern-biotech-stocks-have-probability-of-constructing-a-breakthrough-in-2025/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Mon, 30 Dec 2024 00:54:50 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[biotech]]></category>
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		<category><![CDATA[innovative]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=21786</guid>

					<description><![CDATA[After several years of poor performance, the trend could change in favor of biotech stocks in 2025, but it surely would still be sensible to bet cautiously on a few of the most modern names. &#8220;We&#39;re still optimistic about the outlook for biotech,&#8221; said Stacey Sears, senior vp and portfolio manager at Emerald Advisors, in [&#8230;]]]></description>
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<p><span hidden="" aria-hidden="true" class="ArticleBody-extraData"><span hidden="" aria-hidden="true" class="ArticleBody-extraData"><span hidden="" aria-hidden="true" class="xyz-data">After several years of poor performance, the trend could change in favor of biotech stocks in 2025, but it surely would still be sensible to bet cautiously on a few of the most modern names. &#8220;We&#39;re still optimistic about the outlook for biotech,&#8221; said Stacey Sears, senior vp and portfolio manager at Emerald Advisors, in an interview with CNBC. “I think the performance is below average [makes them] The SPDR S&#038;P Biotech ETF (XBI) is up more than 2% year-to-date but has fallen 9% since the election alone as investors wonder what changes the Trump administration will bring . Investors will gain clarity on the regulation and policy environment in the coming months, Sears said, but in the meantime, the current uncertainty creates an opportunity, particularly among the small- and mid-cap stocks it tracks that are waiting to happen M&#038;A growth in recent years has been held back by a lack of merger and acquisition activity and high interest rates have caused companies&#39; cost of capital to rise and have remained volatile even after the Federal Reserve began cutting interest rates earlier this year. But innovation has flourished and the new year will likely bring a new round of drug approvals and launches that could push stocks higher, analysts say, &#8220;and then we finally see a more significant increase in M&#038;A activity, along with further progress.&#8221; From a clinical perspective, I think this will lead to an increase. &#8220;Eyes back to the group,&#8221; said Sears According to Yuri Khodjamirian, chief investment officer at Tema Funds, major pharmaceutical companies have more than $300 billion in revenue to replace by 2028 and will look to innovative biotech companies to fill the gap close. “The cliff has really increased this year, but it will get stronger in years 25 and 26,” said Terry Smith, head of the Life sciences research at Emerald, expects neurology, immunology and inflammation, oncology and metabolism to be essentially the most attractive clinical areas for Big Pharma M&#038;A activity is resuming. “That&#39;s why we think an active strategy is really important because you have to choose it,” Smith said. “You can’t just own the entire index.” Emerald declined to make specific stock recommendations for the approaching yr. Goldman Sachs analysts see AbbVie, Biogen, Johnson &#038; Johnson, Merck and Roche because the more than likely buyers. Merck is best positioned with &#8220;capital, needs and positioning&#8221; and might point to recent successes, while Johnson &#038; Johnson could also be able to &#8220;pursue a significant target&#8221; after a series of smaller deals, it said. Insmed: A Crucial Year Ahead Insmed is a Buy stock on Goldman&#39;s high-conviction list, and the corporate&#39;s evaluation suggests it could possibly be a sexy takeover goal. Shares are up nearly 125% in 2024, in line with FactSet, and all analysts covering the rare disease researcher rate it a &#8220;buy&#8221; or &#8220;overweight.&#8221; On average, analysts see a gain of greater than 28% from Friday&#39;s close. Next yr “is expected to be another year of value creation for INSM through commercial execution and clinical data catalysts,” Goldman analyst Andrea Newkirk wrote in a research note earlier this month. INSM YTD Mountain Insmed shares year-to-date She explained that the corporate&#39;s estimate of peak global sales of $5.9 billion for Brensocatib &#8220;likely significantly&#8221; underestimates the drug&#39;s true potential. It expects it to be approved by the center of next yr to treat a chronic lung disease called bronchiectasis, but further upside could come from expanded use in other diseases. Insmed also has other respiratory assets in its portfolio that would boost annual peak sales to $8.2 billion, she said. Barclays analyst Leon Wang also likes Insmed, but his focus is on the clinical data expected within the second half of next yr for treprostinil-palmitil inhalation powder, or TPIP, in pulmonary arterial hypertension, or hypertension within the lungs. “We remain positive on this statement and strive for superior efficacy compared to standard treatment with Tyvaso,” Wang wrote in a note to customers in mid-December. &#8220;&#8230;Overall, 2H25 could make INSM a multi-commercial product company starting pivotal trials in two major indications.&#8221; Legend Biotech: Heading for Recovery In the oncology space, several Wall Street analysts are weighing in on the prospects for Legend Biotech optimistic. Shares of the CAR-T specialist are down 46% yr up to now, but the common price goal tracked by FactSet suggests the stock could rise 147% as of Thursday&#39;s close. LEGN YTD Mountain Legend Biotech Stocks Year-To-Date “LEGN stock has been overextended due to what we believe is an unfair comparison of clinical data with. [ Arcellx&#8217; s] Anito-Cel as well as ongoing concerns about China risk, particularly with the new administration coming on board in January 2025,” wrote Barclays analyst Gena Wang, referring to clinical data presented by rival Arcellx on the 2020 conference American Society of Hematology presented Dec. 9. “We believe the facts speak for themselves, and that is what we expect.” [Legend&#8217;s] Carvykti market launch increases in 2025 with possible year-on-year growth of roughly 100% for each 2025 and 2026, driven by the planned implementation of the expansion of production capacities, the extension of the designation to an earlier line of multiple myeloma with probable positives CARTITUDE-5 data in 2025, in addition to continuing to have a superior clinical profile with more mature data to position itself as an industry leader establish,” said Wang. Piper Sandler named Legend one among its biotech focus stocks The investment bank said demand is so strong that there&#8217;s room available in the market for each Legend and its partner Johnson &#038; Johnson, and Arcellx, which works with its partner Gilead Sciences to achieve success. “Stick with what you can measure.” The names Morgan Stanley biotech analysts highlighted of their 2025 outlook: “We expect stocks that have a product with an existing market position combined with a label extension to perform best in 2025 will,” the team wrote on December sixteenth. The legend suits this description, as do corporations like Argenx, Beigene, Sarepta Therapeutics and Rhythm Pharmaceuticals. According to Morgan Stanley, their key theme for 2025 is to “stick with what you can measure.” Legends are one among the simplest categories to measure since it is an existing product that has the possibility to extend sales. The company&#39;s next area includes stocks like Insmed and Jazz Pharmaceuticals, whose predominant driver is either a recent drug approval or an upcoming product launch. The final group they put together was a listing of corporations which have “material catalysts” that could lead on to commercialization beyond next yr. This more speculative group includes Rocket Pharmaceuticals, an organization developing a treatment for Danon disease, a rare inherited disorder that sometimes results in fatal heart problems. According to FactSet, Rocket shares are down nearly 61% year-to-date, and consensus price targets suggest a rise of nearly 285% from Friday&#39;s close. Morgan Stanley expects a catalyst for the stock in late 2025, when Phase 2 trial data for Rocket&#39;s RP-A501 gene therapy is predicted. These are only a number of examples of the innovations biotech analysts are seeing and why they&#8217;re confident that the sector&#39;s development will pick up. “You can only have so many bad years, right?” said Khodjamirian of Tema. “At some point the valuations appear very attractive. If you take a look at the healthcare sector basically, it&#39;s trading at a few 23% discount to the S&#038;P 500, which is one among the bottom discounts we&#39;ve ever seen, actually within the last 20 years.</span></span></span><span class="HighlightShare-hidden" style="top:0;left:0"></span></p>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>What Google&#039;s quantum chip breakthrough means for the longer term of Bitcoin</title>
		<link>https://bloggingthree.soflytech.com/2024/12/what-googles-quantum-chip-breakthrough-means-for-the-longer-term-of-bitcoin/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Mon, 23 Dec 2024 00:16:55 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[Bitcoin]]></category>
		<category><![CDATA[Breakthrough]]></category>
		<category><![CDATA[chip]]></category>
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		<category><![CDATA[Quantum]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=21415</guid>

					<description><![CDATA[Google&#39;s recent announcement of the launch of Willow, a quantum chip that has reduced the error bias of a few of its predecessors, is a milestone in its efforts to bring quantum computing into the true world and will change the way in which things move forward in the approaching years We think concerning the [&#8230;]]]></description>
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<p>Google&#39;s recent announcement of the launch of Willow, a quantum chip that has reduced the error bias of a few of its predecessors, is a milestone in its efforts to bring quantum computing into the true world and will change the way in which things move forward in the approaching years We think concerning the risk of cryptocurrencies.</p>
<p>Willow&#39;s speed is sort of unbelievable &#8211; <a href="https://blog.google/technology/research/google-willow-quantum-chip/" target="_blank">based on Google</a>is able to performing a calculation in lower than five minutes that might take one in all today&#39;s fastest supercomputers 10 septillion years to resolve. Ten septillion is 10,000,000,000,000,000,000,000,000 years. </p>
<p>But the accuracy of quantum computing has also been an enormous problem to this point, because quanta are like a garden hose that&#8217;s running at full speed and nobody is holding it: the water flows out quickly, but its destination is just not all the time precise. Willow&#39;s combination of speed and accuracy could theoretically give hackers the tools to unlock the algorithms that power Bitcoin and other cryptocurrencies.</p>
<h3 class="ArticleBody-smallSubtitle">Qubits and Bitcoin can coexist for now  </h3>
<p>If you don&#39;t understand (and never many individuals do) what constitutes quantum computing &#8211; qubits &#8211; Tim Hollebeek, industry technology strategist at security firm DigiCert, has a simplistic way of serious about the breakthrough. He says, imagine a maze and the way a classical computer would try to seek out its way through the maze from start to complete. It would try one possible path at a time. “A quantum computer would be able to try every path at the same time, which would lead to a much faster solution,” Hollebeek said.</p>
<p>While Willow is probably not ready for real-world applications yet, Willow&#39;s speed and accuracy will help pave the way in which for larger quantum computers.</p>
<p>“Part of the problem with qubits is that they are unstable and produce errors. This chip has significant error correction capabilities, which mitigates some of the qubit problems,” said Hollebeek.</p>
<p>That means chips improved after Willow&#39;s breakthrough could help hackers goal crypto &#8211; but at the least for now, the priority is just theoretical.</p>
<p>“Quantum computers can theoretically solve this much faster and pose a threat to today&#39;s cryptographic algorithms if a quantum computer with enough qubits could be developed,” Hollebeek said. But he added that the real-world reason you&#8217;ll be able to breathe easier when owning crypto today is easy. “There is none today and is not expected for the next 5, 10, 15 years,” he said, with the fastest five-year timeline depending on an unexpected technological breakthrough.</p>
<h3 class="ArticleBody-smallSubtitle">A decade-long lead for crypto</h3>
<p>A Google spokesperson told CNBC that Willow and crypto could coexist. “The Willow chip is not capable of breaking modern cryptography,” he said, adding that Google also believes that quantum technology with this capability remains to be years away.</p>
<p>According to Park Feierbach, a decentralized finance technology expert and CEO of Radiant Commons, even when Willow dramatically increased the speed at which crypto might be cracked, the Quantum chip would still need again and again the universe age to do it. According to NASA, the universe is 13.7 billion years old.</p>
<p>“There is almost no reason to use Willow in this technology in a way that could make manageable progress. It would still take too long,” said Feierbach.</p>
<p>“Estimates suggest that we are at least 10 years away from cracking RSA and that it would require about 4 million physical qubits,” the Google spokesperson said. RSA is an encryption system utilized in cryptocurrencies. </p>
<p>To illustrate: Google&#39;s processors now have a size of around 100 physical qubits.</p>
<h3 class="ArticleBody-smallSubtitle">“Quantum-safe” algorithms</h3>
<p>The Google spokesperson emphasized that the timeline for quantum breakthroughs is essentially shared and Willow has not modified it. </p>
<p>“Google is on the right track with our planned roadmap,” he said. “The security community has long been aware of the planned timeline for breaking asymmetric encryption and is working to define standards and jointly implement new algorithms that can withstand attacks from both classical and quantum computers,” the spokesperson added.</p>
<p>In fact, Hollebeek says the crypto industry is working on “quantum-safe” crypto.</p>
<p>The National Institute of Standards and Technology (NIST) has released several quantum-safe algorithms which might be proof against attacks from future quantum computers, Hollebeek said, and NIST has a roadmap for governments and industry to make use of these algorithms to make sure the country&#39;s security and Trade secrets.</p>
<p>“Google and other industry leaders have supported standardization and experimented with the algorithms as drafted,” the Google spokesperson said. </p>
<p>Even though quantum is efficient at deciphering algorithms (traditional crypto equations based on the factorization of enormous prime numbers), they should not infallible, and therein lies the promise of quantum-safe crypto.</p>
<p>“They&#39;re really, really good at some things, but not everything,” Hollebeek said, noting that breaking conventional asymmetric cryptography happens to be one in all the things they&#39;re really good at. “Fortunately, they perform poorly at other difficult math problems, and asymmetric cryptography can be updated to use these difficult math problems instead of factorization,” he said.</p>
<p>Taqi racing<strong>,</strong> Assistant professor of electrical and computer engineering on the University of Massachusetts Amherst said existing cryptos have to be further developed to fend off qubits. “As the potential of quantum computers to break existing cryptography becomes increasingly concerning, new cryptocurrencies specifically designed for quantum security may be developed. These new quantum cryptos would integrate PQC, cryptographic algorithms that are resistant to the computing power of quantum computers,&#8221; Raza said.</p>
<p>Jeremy Allaire, co-founder, chairman and CEO of digital currency company Circle, said in an interview with CNBC last week that the risk is real, but his focus on the future remains focused on the opportunities that will arise. “The bottom line is that quantum crypto means you can both more easily unlock things that had bad old locks and also create better locks,” Allaire said. “So quantum crypto – this quantum will actually be a huge turbo for crypto computing, for crypto applications and for crypto money.”</p>
<p>Raza expects that the broader changes led to by quantum computing will ultimately extend beyond crypto. Breakthroughs will make devices and software faster, revolutionize AI, and improve data security with highly secure encryption methods. In on a regular basis life, there will probably be advances in computing, healthcare, energy and security, Raza said, and subsequently it is just not the crypto industry that we must always take into consideration in isolation while these changes are still unfolding. “They will probably change the industry,” he said.</p>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>F1 driver Sergio Pérez is having a “terrible” season. Can he make a breakthrough at home in Mexico?</title>
		<link>https://bloggingthree.soflytech.com/2024/10/f1-driver-sergio-perez-is-having-a-terrible-season-can-he-make-a-breakthrough-at-home-in-mexico/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Sat, 26 Oct 2024 23:11:33 +0000</pubDate>
				<category><![CDATA[Sports]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=18045</guid>

					<description><![CDATA[MEXICO CITY — As his son looked on, arms folded on the appropriate side of the rostrum on the Autodromo Hermanos Rodriguez, Sergio Pérez savored the admiration of his home fans. Although Max Verstappen won the race for Red Bull, third-placed Pérez caught the eye of the group after scoring his first podium on the [&#8230;]]]></description>
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<p>MEXICO CITY — As his son looked on, arms folded on the appropriate side of the rostrum on the Autodromo Hermanos Rodriguez, Sergio Pérez savored the admiration of his home fans.</p>
<p>Although Max Verstappen won the race for Red Bull, third-placed Pérez caught the eye of the group after scoring his first podium on the Mexican Grand Prix. Although it was his fifth podium finish of the 2021 season, it was the primary time a Mexican rider had achieved such a result at home, making it a big result for each him and his country.</p>
<p>Three years later, things have modified dramatically.</p>
<p>Pérez stays the star in Mexico. That stays <i>be</i> Over the weekend, his face is plastered on billboards across the town as brands and sponsors attempt to capitalize on his fame. Red Bull team principal Christian Horner joked that Pérez is “endorsing every product from Uber Eats to toilet paper this weekend.”</p>
<p>But in the intervening time, after a poor run of form that saw him fall to eighth within the World Championship, one other podium finish for Pérez would carry much more weight.</p>
<p>“I know I had a terrible season, a very difficult one,” Pérez admitted on Thursday. “It started really well, but it was really, really difficult. If I achieve a strong result, it can definitely change my personal season massively.”</p>
<p>Pérez involves Mexico with no podium finish because the Chinese Grand Prix in April. A season that began so promisingly, with Red Bull appearing to be one step ahead of its rivals, quickly unraveled because it struggled with the automobile. A scarcity of balance, which has robbed drivers of confidence this 12 months, only began to weigh on Max Verstappen towards the tip of the European season. It hurt Pérez much earlier.</p>
<p>The resulting decline in form put Pérez&#39;s future within the highlight. Red Bull&#39;s lead in the beginning of the 12 months faded as McLaren, supported by two high-scoring drivers, Lando Norris and Oscar Piastri, caught up with it and eventually overtook it at the highest of the constructors&#39; championship. While Verstappen maintains a good lead at the highest of the Drivers&#39; Championship, Red Bull is now in peril of slipping to P3, also behind Ferrari &#8211; just eight points behind. That could be the bottom constructors&#39; rating since 2019.</p>
<p>Before Mexico, Pérez felt the necessity to reply to rumors that he might announce his plan to retire from Formula 1 entirely at his home race. During the three-week break to Singapore, he released a video clip from &#8220;The Wolf of Wall Street&#8221; during which Jordan Belfort, Leonardo di Caprio&#39;s character, confidently says words like &#8220;I&#39;m not leaving&#8221; to his staff.</p>
<blockquote class="twitter-tweet" data-width="550" data-dnt="true">
<p lang="en" dir="ltr">Sorry <img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f602.png" alt="😂" class="wp-smiley" style="height: 1em; max-height: 1em;" /><img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f923.png" alt="🤣" class="wp-smiley" style="height: 1em; max-height: 1em;" /><img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f923.png" alt="🤣" class="wp-smiley" style="height: 1em; max-height: 1em;" /><img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f923.png" alt="🤣" class="wp-smiley" style="height: 1em; max-height: 1em;" /><img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f923.png" alt="🤣" class="wp-smiley" style="height: 1em; max-height: 1em;" /><img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f923.png" alt="🤣" class="wp-smiley" style="height: 1em; max-height: 1em;" /> <a href="https://t.co/rPIHpYDVGH">pic.twitter.com/rPIHpYDVGH</a></p>
<p>— Sergio Pérez (@SCecoPerez) <a href="https://twitter.com/SChecoPerez/status/1840404121490264412?ref_src=twsrc%5Etfw">September 29, 2024</a></p>
</blockquote>
<p>&#8220;I just felt like every year for about two years now, it&#39;s been like this where someone creates this rumor and then everyone picks up on it,&#8221; Pérez explained in Austin last week when asked concerning the post. “All my fans, in fact I&#8217;m very aware that lots of persons are coming to support me on the Mexican Grand Prix and that they&#8217;re probably expecting something that is just not true.</p>
<p>&#8220;I felt the need to just say: Look, I think it&#39;s just not right to spread rumors like that without knowing the facts.&#8221;</p>
<p>The frequency of those rumors comes as Pérez&#39;s poor performance and his future are under scrutiny, despite being under contract for the following two seasons. His renewal was intended to present him stability at a time when his form was flagging and act as an additional arm around his shoulder &#8211; proof that he had the support of the team.</p>
<p>It didn&#39;t have the specified effect. Pérez has still not finished in the highest five because the deal was announced just before the Canadian Grand Prix. Last month he was fighting for the rostrum in Azerbaijan, but a late collision with Carlos Sainz ended his race.</p>
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<div class="wp-caption-image-container"><img loading="lazy" decoding="async" loading="lazy" class="wp-image-5873849 size-full" src="https://static01.nyt.com/athletic/uploads/wp/2024/10/25230948/GettyImages-2181058733-scaled.jpg" alt="" width="2560" height="1682" srcset="https://static01.nyt.com/athletic/uploads/wp/2024/10/25230948/GettyImages-2181058733-scaled.jpg 2560w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25230948/GettyImages-2181058733-300x197.jpg 300w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25230948/GettyImages-2181058733-1024x673.jpg 1024w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25230948/GettyImages-2181058733-1536x1009.jpg 1536w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25230948/GettyImages-2181058733-2048x1346.jpg 2048w" sizes="auto, (max-width: 2560px) 100vw, 2560px"></p>
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      <span class="credits-text">Pérez during training on Friday in Mexico City. (Jared C. Tilton/Getty Images)</span></div>
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<p>On Friday, Horner agreed with Pérez&#39;s assessment that his season had been &#8220;terrible,&#8221; saying the Mexican had &#8220;summed it up perfectly.&#8221;</p>
<p>“It was a bad year for Checo,” Horner said. “He started strong and obviously he has struggled for form since Imola. It was sporadic. We saw flashes of performance. (In) Azerbaijan he probably could have won this race almost a month ago.</p>
<p>“We know what he is capable of. We hope we can give him the setup and confidence in the car to get the performance we think he is capable of.”</p>
<p>Verstappen&#39;s increasing problems through the summer races suggested that Pérez was not solely chargeable for his lack of form. The upgrades introduced in Austin helped address a few of Verstappen&#39;s concerns, but Pérez &#8211; who qualified ninth and only finished seventh &#8211; didn&#39;t have the whole package. “We just didn’t have a good weekend,” he said in Mexico. “It wasn’t a good weekend where I built a lot of confidence.”</p>
<p>Red Bull has long been trying to present Pérez confidence again heading into 2025. “Checo is our driver,” Horner said. “He has a contract until 2025. He is competitive. He&#39;s hungry. He is not happy with where he is currently. That’s why we as a team are doing our best to support him.”</p>
<p>Horner was asked how Liam Lawson&#39;s performances at RB could impact the plans of each Red Bull teams, as he could potentially replace Pérez within the event of a move to Red Bull. Horner reiterated that Pérez “has a contract for next year, so he is currently our driver for 2025.”</p>
<p>“There is one place available at RB and they are all Red Bull racing drivers on loan,” said Horner. “We have the time to sit down with Laurent (Mekies) and Peter (Bayer) and examine all options.”</p>
<div id="attachment_5873879" class="wp-caption alignnone">
<div class="wp-caption-image-container"><img loading="lazy" decoding="async" loading="lazy" class="wp-image-5873879 size-full" src="https://static01.nyt.com/athletic/uploads/wp/2024/10/25233302/GettyImages-2180830562-scaled.jpg" alt="" width="2560" height="1707" srcset="https://static01.nyt.com/athletic/uploads/wp/2024/10/25233302/GettyImages-2180830562-scaled.jpg 2560w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25233302/GettyImages-2180830562-300x200.jpg 300w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25233302/GettyImages-2180830562-1024x683.jpg 1024w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25233302/GettyImages-2180830562-1536x1024.jpg 1536w, https://static01.nyt.com/athletic/uploads/wp/2024/10/25233302/GettyImages-2180830562-2048x1365.jpg 2048w" sizes="auto, (max-width: 2560px) 100vw, 2560px"></p>
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      <span class="credits-text">The fan adoration for Pérez in Mexico City knows no bounds. (Mark Thompson/Getty Images)</span></div>
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<p>If there was one among the remaining five races where the energy of the event and the group could give Pérez an additional boost of energy, it&#39;s Mexico. The intensity of the race weekend is comparable to nothing else he experiences in Formula 1. He described it as “like three races at once.” The noise from the stands at his first outlap in the beginning of FP1 was greater than most drivers will hear all season of their honor, such is the joy of the over 100,000 Mexicans who crowded the circuit, of whom the Most of the noise within the Foro Sol section of the stadium burst into color.</p>
<p>The demands of racing at home make the week tiring. Still, it doesn&#39;t change how special the Grand Prix is ​​for him. “I just want to enjoy it,” he said in Austin. “This is my ninth Grand Prix in Mexico, so I just want to make sure I enjoy every single part of it because it&#39;s a very important one.”</p>
<p>The only noise Pérez wants to listen to this weekend comes from the stands. The constant speculation and discussions about his future? It doesn&#39;t trouble him. “You just have to make sure you keep your head down and focus on the things you can control,” Pérez said. “The rest is something you can’t deal with.”</p>
<p>Ending the rostrum drought on home soil could be an ideal way for Pérez to clear up among the query marks over his future at Red Bull. It would also give him the possibility for one more priceless moment just like the one together with his son three years ago.</p>
<p>“This moment will forever remain in my memory, my son standing on the podium with me, watching me,” Pérez said. “I hope he remembers this forever. If not, at least I&#39;ll have the picture to show him when he&#39;s older!</p>
<p>“These moments, in my opinion, are the ones that really matter to me. And I hope I can do it again this weekend.”</p>
<blockquote class="twitter-tweet" data-width="550" data-dnt="true">
<p lang="en" dir="ltr">I remember how Sergio Perez&#39;s son was in a position to see his father on the rostrum at his home Grand Prix <img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f49a.png" alt="💚" class="wp-smiley" style="height: 1em; max-height: 1em;" /><img src="https://s.w.org/images/core/emoji/17.0.2/72x72/1f1f2-1f1fd.png" alt="🇲🇽" class="wp-smiley" style="height: 1em; max-height: 1em;" /></p>
<p>(via rsanchezp/IG) <a href="https://t.co/tsFzL1JMHu">pic.twitter.com/tsFzL1JMHu</a></p>
<p>— ESPN F1 (@ESPNF1) <a href="https://twitter.com/ESPNF1/status/1546887113861373954?ref_src=twsrc%5Etfw">July 12, 2022</a></p>
</blockquote>
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<p><script async src="//platform.twitter.com/widgets.js" charset="utf-8"></script><br />
<br /><em>image credit : www.nytimes.com</em></p>
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		<title>Saturday Night Five: Big 12 madness, Arizona&#039;s breakthrough, Colorado on the brink, Jeanty delivers and the brutal reality of UCLA</title>
		<link>https://bloggingthree.soflytech.com/2024/09/saturday-night-five-big-12-madness-arizonas-breakthrough-colorado-on-the-brink-jeanty-delivers-and-the-brutal-reality-of-ucla/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Sun, 29 Sep 2024 11:11:54 +0000</pubDate>
				<category><![CDATA[Sports]]></category>
		<category><![CDATA[Arizona39s]]></category>
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		<category><![CDATA[Breakthrough]]></category>
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		<category><![CDATA[Brutal]]></category>
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		<category><![CDATA[Jeanty]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=16077</guid>

					<description><![CDATA[1st Conference of Chaos The Big 12 isn&#39;t just drunk, folks. It&#39;s a drooling, smelly, stammering old man stumbling along the sidewalk in broad daylight. And it is completely gorgeous. We knew the conference would exude parity and unpredictability long before the 16-team first meet, but September was ridiculous. Up is down, down is up, [&#8230;]]]></description>
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<h3>1st Conference of Chaos</h3>
<p>The Big 12 isn&#39;t just drunk, folks. It&#39;s a drooling, smelly, stammering old man stumbling along the sidewalk in broad daylight. And it is completely gorgeous.</p>
<p>We knew the conference would exude parity and unpredictability long before the 16-team first meet, but September was ridiculous.</p>
<p>Up is down, down is up, and logic has left the stage (similar to Oklahoma State&#39;s offense).</p>
<p>The most up-to-date example got here in the ultimate game of Week 5, when Arizona, most recently blown off the sector by Kansas State, went to Rice-Eccles Stadium and beat Utah, most recently dominated by Oklahoma State.</p>
<p>Picked to win the Big 12 within the preseason media poll, the Utes are looking up within the standings — at their bitter enemy.</p>
<p>Brigham Young, which was ranked thirteenth in the identical media poll, is currently in first place at 5-0 and shares first place with Colorado, which was ranked eleventh, and Texas Tech, which was ranked ninth. All three teams are 2-0 in conference play.</p>
<p>At the underside of the rankings we discover the Cowboys, who were picked third, and Kansas, who got here in fourth.</p>
<p>Try to grasp Kansas State, which faced Arizona, was knocked out by BYU, after which faced Oklahoma State in three straight weekends.</p>
<p>Try to elucidate how a team (Texas Tech) that needed time beyond regulation to beat Abilene Christian could possibly be at the highest of the league.</p>
<p>Or how a team (TCU) that lost by 24 points at SMU could turn things around and win by 11 points at Kansas.</p>
<p>Admittedly, not every aspect of the conference was unpredictable:</p>
<p>– Utah quarterback Cam Rising is injured again.</p>
<p>– Baylor coach Dave Aranda is in the recent seat.</p>
<p>– Colorado cornerback/receiver Travis Hunter is otherworldly.</p>
<p>– Iowa State is undefeated.</p>
<p>– Houston is terrible.</p>
<p>But that&#39;s where the logic ends.</p>
<p>Is two more months of this madness an excessive amount of to ask?</p>
<h3>2. This is more prone to be true</h3>
<p>We mentioned Arizona&#39;s win within the opening paragraph, but it surely deserves additional context.</p>
<p>Yes, the Utes were without Rising once more, and that may&#39;t be ignored.</p>
<p>But the identical team, with freshman Isaac Wilson at quarterback, coached Oklahoma State every week ago in sweltering Stillwater. While Rising&#39;s absence ought to be considered, it hardly explains every little thing about Arizona&#39;s 23-10 win.</p>
<p>This was the primary full game of the Wildcats&#39; season &#8211; the type of performance we saw from them late last 12 months, and the type of performance we expected early and sometimes this 12 months.</p>
<p>The defense stood firm at the road of scrimmage and made plays within the secondary.</p>
<p>Quarterback Noah Fifita excelled under pressure, and receiver Tetairoa McMillan had loads of assist in the air game.</p>
<p>All in all, it was precisely the overall performance that first-year coach Brent Brennan expected from his team after the poor performance at Kansas State two weeks ago.</p>
<p>And because the trip to Manhattan was a non-conference game, the Wildcats are undefeated in Big 12 play and well-positioned to weather the chaos.</p>
<h3>3. Brilliance on blue lawns</h3>
<p>The matchup between Washington State and Boise State wasn&#39;t one among the highest matchups of Week 5, but it surely did have significant postseason stakes.</p>
<p>The Cougars needed a win to take care of their slim hopes of creating the College Football Playoff, while the Broncos are fighting for the automated bid, which matches to the top-ranked team within the Group of Five.</p>
<p>But the showdown quickly developed into the Ashton-Jeanty show.</p>
<p>The sensational Boise State tailback managed a 64-yard touchdown run within the opening minutes after which rushed for 259 yards (plus 4 touchdowns) to provide the Broncos a 45-24 victory.</p>
<p>He is now averaging 211.3 yards per game and 10.3 yards per carry.</p>
<p>Jeanty earns a spot in New York City on the Heisman Trophy ceremony.</p>
<h3>4. Bowling in Boulder</h3>
<p>The most complete performance of the Deion Sanders era brought Colorado inside two wins of a bowl berth.</p>
<p>In fact, we&#39;re calling it here and now: Combine an improvement within the lines of scrimmage with an unexpected weakness of their schedule, and the Buffaloes are a lock for the postseason.</p>
<p>With an overall record of 4-1, they&#8217;ve a major margin for error heading into October, and they&#8217;re going to proceed to face several error-prone opponents moving forward.</p>
<p>Kansas State is 4-1 but hasn&#39;t played well on the road, and the Oct. 12 matchup is in Boulder.</p>
<p>Cincinnati didn&#39;t get a great win, losing to the one strong opponent within the September tournament (Pittsburgh).</p>
<p>Colorado&#39;s final month begins with a visit to Texas Tech &#8211; one other winnable game &#8211; and its final two opponents, Kansas and Oklahoma State, are struggling.</p>
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</aside>
<p>In other words, CU only needs a 2-5 record to qualify for the postseason and still has a ton of winnable games ahead of it.</p>
<h3>5. Abhorrent brutality</h3>
<p>Let&#39;s observe a moment of silence for the 2024 UCLA football season. May it rest in peace.</p>
<p>In case you weren&#39;t being attentive, the Bruins began with a narrow win over a nasty team, Hawaii, after which were knocked out of the Rose Bowl by a great team, Indiana.</p>
<p>Fortunately, the schedule became easier at this point and the Bruins headed to Death Valley to face LSU, where they were overwhelmed within the second half in a 17-point loss.</p>
<p>The weak streak continued Saturday when Oregon visited and, with two weeks to arrange, built a 25-point lead in the primary half before sailing to victory.</p>
<p>And next week comes the best task of all for UCLA, which flies across the country to face Penn State in Fox&#39;s &#8220;Big Noon&#8221; window.</p>
<p>Yes, in spite of everything that, the Bruins (1-3) at the moment are tasked with playing in the course of Pennsylvania at 9 a.m. Pacific time.</p>
<p>Welcome to the Big Ten.</p>
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<p><em>image credit : www.mercurynews.com</em></p>
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		<title>Pharmaceutical firms are betting billions that targeted radiation could bring the following breakthrough within the fight against cancer</title>
		<link>https://bloggingthree.soflytech.com/2024/09/pharmaceutical-firms-are-betting-billions-that-targeted-radiation-could-bring-the-following-breakthrough-within-the-fight-against-cancer/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Mon, 16 Sep 2024 17:19:06 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Betting]]></category>
		<category><![CDATA[billions]]></category>
		<category><![CDATA[Breakthrough]]></category>
		<category><![CDATA[bring]]></category>
		<category><![CDATA[cancer]]></category>
		<category><![CDATA[companies]]></category>
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		<category><![CDATA[Pharmaceutical]]></category>
		<category><![CDATA[radiation]]></category>
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		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=14911</guid>

					<description><![CDATA[Pharmaceutical firms consider that direct radiation of tumors shall be the following big breakthrough within the fight against cancer. Bristol-Myers Squibb, AstraZeneca, Eli Lilly and other pharmaceutical firms have spent around $10 billion on acquisitions or partnerships with radiopharmaceutical manufacturers, buying up smaller upstarts to realize access to a technology that, while still in its [&#8230;]]]></description>
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<p>Pharmaceutical firms consider that direct radiation of tumors shall be the following big breakthrough within the fight against cancer. </p>
<p><span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-1">Bristol-Myers Squibb<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>, <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-2">AstraZeneca<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>, <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-3">Eli Lilly<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>    and other pharmaceutical firms have spent around $10 billion on acquisitions or partnerships with radiopharmaceutical manufacturers, buying up smaller upstarts to realize access to a technology that, while still in its infancy, could treat quite a few sorts of cancer. </p>
<p>&#8220;Any large company that is in oncology or for which oncology is an important therapeutic category will likely need to have a presence in this space in one way or another,&#8221; said Michael Schmidt, an analyst at Guggenheim Securities.</p>
<p>Two radiopharmaceuticals from Novartis are already available. A dozen more are in development, Schmidt said. The total market potential is difficult to estimate because there are such a lot of possible sorts of cancer that may very well be treated with the drugs, he said.</p>
<p>Schmidt predicts that the category could generate sales of lower than $5 billion if the technology stays limited to treating some cancers similar to prostate cancer and neuroendocrine tumors,<strong> </strong>as much as ten billion if it seems that<strong> </strong>effective against more sorts of cancer.</p>
<p>The drugs work by attaching radioactive material to a goal molecule that appears for and binds to a selected marker on cancer cells. The trick is finding markers<strong> </strong>which might be present on cancer cells but not on healthy cells. This allows the treatment to irradiate the cancer cells and protect the remainder of the body from the extent of the<strong> </strong>Damage related to many cancer drugs. </p>
<p>It has taken a while to prove that the technology is each scientifically and financially viable. The first radiopharmaceuticals were approved within the early 2000s, but interest from major pharmaceutical firms has only recently increased. </p>
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<p>Producing the drugs requires a posh manufacturing process and logistics, two major drawbacks. Radioactive material decays quickly, so patients have to be treated inside days of the drug being manufactured. </p>
<p>Pharmaceutical firms have proven that they&#8217;ll develop complex, time-critical drugs similar to CAR-T for blood cancer or gene therapies for rare diseases. Then Novartis showed that these strategies may also be applied to radiopharmaceuticals. </p>
<p>The Swiss pharmaceutical giant received approval in 2018 for a radiopharmaceutical called Lutathera for a rare variety of cancer of the pancreas and gastrointestinal tract.<strong> </strong>In 2022, Novartis received one other approval for the prostate cancer drug Pluvicto. Together, the drugs are expected to generate sales of about $4 billion by 2027, in accordance with consensus estimates from FactSet. </p>
<p>These successes sparked broader interest in radiopharmaceuticals. </p>
<p>&#8220;We put all this together and thought we should do something, we need to do business here,&#8221; said Jacob Van Naarden, president of Eli Lilly&#39;s oncology business. </p>
<p>Lilly acquired radiopharmaceutical maker Point Biopharma last yr for about $1.4 billion and likewise formed some partnerships with firms developing the drugs. One of an important aspects in Lilly&#39;s initial search was whether the businesses were willing to make the drugs, Van Naarden said. Radiopharmaceuticals usually are not easy to make, and Lilly desired to make sure that that an initial acquisition would allow it to supply the drugs itself relatively than outsourcing the work. </p>
<p>Manufacturing was also a key component in Bristol Myers Squibb&#39;s $4.1 billion acquisition of RayzeBio, said Ben Hickey, RayzeBio&#39;s president. At the time of the acquisition, RayzeBio was nearing completion of a factory in Indiana and had secured its own supply of radioactive material needed to develop the experimental drugs in its pipeline. </p>
<p>“It was obviously one of the criteria to make sure we were in control of our own destiny,” Hickey said. </p>
<p>Novartis has shown why that is so vital, as the corporate initially struggled to supply enough doses of Pluvicto. The company is currently investing greater than $300 million to open and expand radiopharmaceutical manufacturing facilities within the United States to supply the drug and deliver it quickly to patients. The company is now capable of meet demand for the drug, which requires careful planning of distribution. </p>
<p>Each dose is provided with a GPS tracker to make sure it gets to the appropriate patient at the appropriate time, said Victor Bulto, president of Novartis&#39; U.S. business. Novartis is delivering the doses to destinations inside nine hours of the factory to attenuate the danger of disruption from storms, Bulto said. </p>
<p>Doctors and patients on the receiving side also sense the complexity. </p>
<p>The Bassett Healthcare Network in upstate New York needed to renew its medical license to handle radioactive material before it could administer Lutathera and Pluvicto, said Dr. Timothy Korytko, Bassett&#39;s chief radiation oncologist. The drugs, that are given intravenously, have to be administered by an authorized specialist.</p>
<p>It can take several weeks from the prescription of a radiopharmaceutical to the actual administration. With Pluvicto, patients come every six weeks for as much as six treatments.</p>
<p>Radiopharmaceuticals begin to decay after they&#8217;re produced and subsequently only have a shelf lifetime of a couple of days.</p>
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<p>Ronald Coy knows how vital it&#8217;s to maintain his appointments. Coy, a retired firefighter who has been battling prostate cancer since 2015, drives greater than an hour through upstate New York to receive Pluvicto in Bassett. Coy hasn&#39;t had any problems up to now, but he&#39;s fearful a snowstorm could jeopardize one among his appointments between now and the top of January. </p>
<p>&#8220;Hopefully there won&#39;t be any major storms by then, and if there are, it will be a week before I leave,&#8221; Coy said.</p>
<p>When Coy returns home from treatment, he has to take precautions, similar to staying away from his wife, Sharon, so she is just not exposed to radiation. He drinks a whole lot of water to flush excess radiation from his body. He doesn&#39;t mind slightly inconvenience for a couple of days relating to fighting his cancer.</p>
<p>For Novartis, the investment in infrastructure to fabricate and distribute radiopharmaceuticals could be worthwhile for Pluvicto and Lutathera alone, Bulto said. But it&#8217;s much more attractive due to potential to treat more sorts of cancer. He cites Novartis&#39; work on developing a drug for a marker<strong> </strong>This will be demonstrated in 28 different tumors, including breast, lung and pancreatic cancer. </p>
<p>&#8220;If we could apply all the knowledge we have gained from manufacturing and distribution to patients with lung cancer and breast cancer and potentially demonstrate these significant levels of efficacy and tolerability, we would potentially have a very big impact on cancer treatment. And of course a very viable business as well,&#8221; he said. </p>
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<p>At this point, the query remains to be open. The field remains to be in its infancy, executives say, and the effectiveness of radiopharmaceuticals beyond the cancers they currently treat has yet to be proven.</p>
<p>&#8220;If we can expand the target and tumor type repertoire, this could be a very large class of drugs,&#8221; said Eli Lilly&#39;s Van Naarden, adding that it&#39;s hard to say at this point whether the category shall be &#8220;super important&#8221; or &#8220;just important.&#8221;</p>
<p>Bristol Myers Squibb sees a chance in combining radiopharmaceuticals with existing cancer drugs similar to immunotherapies, says Robert Plenge, head of research at Bristol. AstraZeneca shares this vision.</p>
<p>AstraZeneca spent $2 billion to amass Fusion Pharmaceuticals earlier this yr. Susan Galbraith, the corporate&#39;s executive vp of oncology research and development, points to existing treatment regimens that mix immunotherapy with radiation. </p>
<p>The size of AstraZeneca&#39;s radiopharmaceutical portfolio will ultimately rely on its initial prostate cancer program and other, as-yet-undisclosed targets which might be already within the works, Galbraith said, but she believes the technology will grow to be a very important a part of cancer medicines over the following decade.</p>
<p>It could take years to understand the technology&#39;s true potential, as many experimental drugs are still in early development. One remaining query is whether or not other radiopharmaceuticals are as protected and well-tolerated as Novartis&#39; Pluvicto, particularly those who use other sorts of radioactive materials, Guggenheim analyst Schmidt said. </p>
</div>
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<p>Big pharmaceutical firms aren&#39;t waiting to get within the race. Stories like Coy&#39;s give them confidence that the work pays off. </p>
<p>Coy has undergone quite a few treatments over nearly 10 years for prostate cancer that had spread to his bones. After only one Pluvicto treatment earlier this yr, blood tests showed that Coy&#39;s cancer levels had dropped significantly. </p>
<p>Not everyone responds so well to Pluvicto, and things can at all times change for Coy. But for now, Coy is pleased that he is an element of the group that responds well to Pluvicto. That makes the trips and precautions price it to him. </p>
<p>&#8220;I am very happy every day that – as it stands now – I am part of the third where this works really well for me,&#8221; he said.</p>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>Boeing and Spirit AeroSystems within the highlight at NTSB hearing on panel breakthrough on 737 Max</title>
		<link>https://bloggingthree.soflytech.com/2024/08/boeing-and-spirit-aerosystems-within-the-highlight-at-ntsb-hearing-on-panel-breakthrough-on-737-max/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Wed, 07 Aug 2024 01:14:25 +0000</pubDate>
				<category><![CDATA[Travel]]></category>
		<category><![CDATA[AeroSystems]]></category>
		<category><![CDATA[Boeing]]></category>
		<category><![CDATA[Breakthrough]]></category>
		<category><![CDATA[hearing]]></category>
		<category><![CDATA[Max]]></category>
		<category><![CDATA[NTSB]]></category>
		<category><![CDATA[panel]]></category>
		<category><![CDATA[Spirit]]></category>
		<category><![CDATA[spotlight]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=11203</guid>

					<description><![CDATA[A Boeing A security official told a U.S. Department of Safety hearing on Tuesday that the corporate is working on design changes to avoid a repeat of the near-catastrophic accident involving a door stopper on a virtually recent 737 Max 9 earlier this 12 months. The National Transportation Safety Board – the agency accountable for [&#8230;]]]></description>
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<div id="RegularArticle-ArticleBody-5" data-module="ArticleBody" data-test="articleBody-2" data-analytics="RegularArticle-articleBody-5-2"><span class="HighlightShare-hidden" style="top:0;left:0"></span></p>
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<p>A <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-1">Boeing<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>    A security official told a U.S. Department of Safety hearing on Tuesday that the corporate is working on design changes to avoid a repeat of the near-catastrophic accident involving a door stopper on a virtually recent 737 Max 9 earlier this 12 months.</p>
<p>The National Transportation Safety Board – the agency accountable for investigating aviation accidents within the United States – released greater than 3,000 pages of documents, including interviews with employees of Boeing and the troubled aircraft manufacturer, ahead of its two-day hearing on Flight 1282. <span class="QuoteInBody-quoteNameContainer" data-test="QuoteInBody" id="RegularArticle-QuoteInBody-2">Spirit AeroSystems<span class="QuoteInBody-inlineButton"><span class="AddToWatchlistButton-watchlistContainer" id="-WatchlistDropdown" data-analytics-id="-WatchlistDropdown"><button class="AddToWatchlistButton-watchlistButton" aria-label="Add To Watchlist" data-testid="dropdown-btn"><span class="AddToWatchlistButton-addWatchListFromTag"></span></button></span></span></span>a few of which indicated that rework was needed.</p>
<p>&#8220;I just want to sound a note of caution here: This is not a public relations campaign for Boeing,&#8221; said NTSB Chair Jennifer Homendy. &#8220;This is an investigation into what happened on January 5. Understood?&#8221;</p>
<p>Preliminary investigations found that the bolts holding the door in place weren&#8217;t tightened. While nobody was seriously injured, the accident brought renewed attention to Boeing&#39;s safety procedures and a series of producing defects which have required changes at the corporate&#39;s factories. This included the door stopper being removed last 12 months but not secured.</p>
<p>&#8220;They are working on some design changes that will allow the door or plug to not close until it is firmly closed in the event of a problem,&#8221; said Elizabeth Lund, who&#8217;s accountable for safety at Boeing&#39;s business aircraft division. The changes will probably be implemented throughout the 12 months, Lund said.</p>
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<p>The blowout plunged Boeing back into crisis mode <strong>And</strong> led to a management restructuring, including the appointment of a brand new CEO, Robert <strong>&#8220;</strong>Kelly<strong>&#8220;</strong> Ortberg, a veteran aerospace executive who previously led Rockwell Collins, will begin his role on Thursday.</p>
<p>The accident also caused delays within the delivery of recent aircraft to customers, further straining the renowned US manufacturer&#39;s relationships with airlines and regulators.</p>
<p>Outgoing CEO Dave Calhoun said Boeing is working to finish what it calls &#8220;traveled work,&#8221; wherein defective aircraft components have to be repaired out of sequence before the plane is delivered to customers. Boeing is within the technique of buying back Spirit AeroSystems, a move the corporate says will allow it to maintain a more in-depth eye on quality.</p>
<p>&#8220;We were thrust into uncharted waters where we were swapping doors like we were swapping our underwear, front doors, cargo doors, E/E cargo hold doors,&#8221; said a Boeing worker whose name was redacted from the statement. &#8220;The planes arrive every day in a souped-up state.&#8221;</p>
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<p><em>image credit : www.cnbc.com</em></p>
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		<title>July 5: Dolly the sheep marks the breakthrough in cloning research</title>
		<link>https://bloggingthree.soflytech.com/2024/07/july-5-dolly-the-sheep-marks-the-breakthrough-in-cloning-research/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Fri, 05 Jul 2024 08:19:14 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[Breakthrough]]></category>
		<category><![CDATA[cloning]]></category>
		<category><![CDATA[Dolly]]></category>
		<category><![CDATA[July]]></category>
		<category><![CDATA[marks]]></category>
		<category><![CDATA[research]]></category>
		<category><![CDATA[sheep]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=8185</guid>

					<description><![CDATA[Today is Friday, July 5, the 187th day of the yr 2024. There are 179 days left within the yr. Today’s highlight of the story: On July 5, 1996, Dolly the sheep was born, the primary mammal to be cloned from an adult somatic cell by scientists on the Roslin Institute of the University of [&#8230;]]]></description>
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<p>Today is Friday, July 5, the 187th day of the yr 2024. There are 179 days left within the yr.</p>
<h4>Today’s highlight of the story:</h4>
<p>On July 5, 1996, Dolly the sheep was born, the primary mammal to be cloned from an adult somatic cell by scientists on the Roslin Institute of the University of Edinburgh.</p>
<h4>Also on this date:</h4>
<p>In 1687, Isaac Newton first published his Principia Mathematica, a three-volume work wherein he set out his mathematical principles of natural philosophy.</p>
<p>In 1811, Venezuela became the primary South American country to declare its independence from Spain.</p>
<aside class="related left"></aside>
<p>In 1852, Frederick Douglass delivered his speech “What Does the Fourth of July Mean to the Slaves?” at Corinthian Hall in Rochester, New York.</p>
<p>In 1865, the Secret Service Division of the U.S. Treasury Department was founded in Washington, DC with the goal of stopping counterfeit money.</p>
<p>In 1935, President Franklin D. Roosevelt signed the National Labor Relations Act.</p>
<p>In 1937, Hormel introduced a canned meat product called Spam; since then, greater than 9 billion cans have been sold.</p>
<p>In 1940, during World War II, Great Britain and the Vichy government in France broke off diplomatic relations.</p>
<p>In 1943, the Battle of Kursk began in World War II. In the weeks that followed, the Soviets succeeded in repelling the Germans several times, who eventually retreated in defeat.</p>
<p>In 1946, the trendy bikini, designed by Frenchman Louis Reard, was first presented in Paris.</p>
<p>In 1947, Larry Doby made his debut with the Cleveland Indians, becoming the primary black player within the American League, three months after Jackie Robinson broke segregation within the National League.</p>
<p>In 1954, Elvis Presley recorded his first single, “That&#39;s All Right,” at Sun Studio in Memphis, Tennessee.</p>
<p>In 1971, President Richard Nixon ratified the twenty sixth Amendment to the U.S. Constitution, which lowered the minimum voting age from 21 to 18.</p>
<p>In 1975, Arthur Ashe became the primary black man to win a Wimbledon singles title by defeating Jimmy Connors.</p>
<p>In 1977, the Pakistani army under General Mohammad Zia ul-Haq seized power from President Zulfikar Ali Bhutto (ZUL&#39;-fih-kahr ah-LEE&#39; BOO&#39;-toh).</p>
<p>In 1980, Björn Borg became the primary male player to win five consecutive Wimbledon singles titles.</p>
<p>Amazon was founded in 1994 by Jeff Bezos as a web based marketplace for books.</p>
<p>In 2011, a jury in Orlando, Florida, found 25-year-old Casey Anthony not guilty of murder, manslaughter and child abuse in reference to the disappearance and death of her two-year-old daughter Caylee in 2008.</p>
<p>In 2013, Pope Francis canonized two of probably the most influential popes of the twentieth century within the Roman Catholic Church by approving a miracle vital for the canonization of Pope John Paul II and overriding Vatican regulations to honor Pope John XXIII.</p>
<h4>Today&#39;s birthdays:</h4>
<ul>
<li>Julie Nixon Eisenhower is 76.</li>
<li>Rock star Huey Lewis is 74.</li>
<li>Baseball Hall of Fame pitcher Rich “Goose” Gossage is 73.</li>
<li>NFL Hall of Fame receiver James Lofton is 68.</li>
<li>Cartoonist Bill Watterson (Calvin and Hobbes) is 66.</li>
<li>Singer-songwriter Marc Cohn is 65.</li>
<li>Actress Edie Falco is 61.</li>
<li>The actress Jillian Armenante is 60 years old.</li>
<li>Actress Kathryn Erbe (er-BEE&#39;) is 59.</li>
<li>Actor Michael Stuhlbarg (STOOL&#39;-bahrg) is 56.</li>
<li>Rapper RZA (RIH&#39;-zuh) is 55.</li>
<li>Author Gary Shteyngart is 52.</li>
<li>R&#038;B singer Joe is 51.</li>
<li>The 5&#39;9&#8243; rapper Royce is 47 years old.</li>
<li>Amelie Mauresmo, member of the International Tennis Hall of Fame, is 45.</li>
<li>Actor Ryan Hansen is 43.</li>
<li>Country musician Dave Haywood (Lady A) is 42.</li>
<li>Actor Danay Garcia is 40.</li>
<li>Soccer player Megan Rapinoe is 39.</li>
<li>Actor Jason Dolley is 33.</li>
<li>Los Angeles Dodgers pitcher and designated hitter Shohei Ohtani is 30.</li>
</ul>
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<p><em>image credit : www.mercurynews.com</em></p>
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		<title>Science &#124;  Breakthrough therapies at Stanford save lives.  Can we afford them?</title>
		<link>https://bloggingthree.soflytech.com/2024/05/science-breakthrough-therapies-at-stanford-save-lives-can-we-afford-them/</link>
		
		<dc:creator><![CDATA[chandankumarsoft]]></dc:creator>
		<pubDate>Sun, 12 May 2024 15:55:41 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[afford]]></category>
		<category><![CDATA[Breakthrough]]></category>
		<category><![CDATA[Lives]]></category>
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		<category><![CDATA[science]]></category>
		<category><![CDATA[Stanford]]></category>
		<category><![CDATA[therapies]]></category>
		<guid isPermaLink="false">https://bloggingthree.soflytech.com/?p=3275</guid>

					<description><![CDATA[Using the body&#39;s own cells to fight disease &#8211; long a medical dream &#8211; is now finally a reality. Now comes the bill. Last month Stanford the primary hospital within the country to make use of a brand new cell therapy value $515,000 to treat a patient with advanced melanoma. A related approachThe project will [&#8230;]]]></description>
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<p>Using the body&#39;s own cells to fight disease &#8211; long a medical dream &#8211; is now finally a reality.</p>
<p>Now comes the bill.</p>
<p>Last month Stanford <a href="https://med.stanford.edu/news/all-news/2024/05/car-t-melanoma.html" target="_blank" rel="noopener">the primary hospital within the country to make use of a brand new cell therapy value $515,000</a> to treat a patient with advanced melanoma. <a href="https://www.cancer.gov/about-cancer/treatment/research/car-t-cells" target="_blank" rel="noopener">A related approach</a>The project will cost $420,000 to $475,000 and can provide hope for patients with deadly blood cancer.</p>
<p>Meanwhile, cells fixed through gene therapy can slow the progression of intractable diseases akin to:  B. decelerate and even stop <a href="https://pubmed.ncbi.nlm.nih.gov/35773052/" target="_blank" rel="noopener">Sickle cell anemia or beta thalassemia</a> – on the exceptional price of $2.1 million to $4.25 million each.</p>
<figure id="attachment_10692137" class="wp-caption aligncenter size-article_inline"><img decoding="async" class="lazyload " alt="Stanford cell therapy technologist Thomas Orozco unfreezes the treated immune cells of a patient with advanced melanoma.  The cells are taken from the patient&#39;s tumor and enriched in a laboratory to better fight the cancer." width="1170" data-sizes="auto" src="https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_0d3a95.jpg?fit=620%2C9999px&#038;ssl=1" data-attachment-id="10692137" srcset="https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_0d3a95.jpg?fit=620%2C9999px&#038;ssl=1 620w,https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_0d3a95.jpg?fit=780%2C9999px&#038;ssl=1 780w,https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_0d3a95.jpg?fit=810%2C9999px&#038;ssl=1 810w,https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_0d3a95.jpg?fit=1280%2C9999px&#038;ssl=1 1280w,https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_0d3a95.jpg?fit=1860%2C9999px&#038;ssl=1 1860w"><figcaption class="wp-caption-text">Stanford cell therapy technologist Thomas Orozco unfreezes the treated immune cells of a patient with advanced melanoma.  The cells are taken from the patient&#39;s tumor and enriched in a laboratory to higher fight the cancer.  Stanford Health Care</figcaption></figure>
<p>Cell therapy technologist Thomas Orozco defrosts the treated immune cells of a patient with advanced melanoma.  The cells are taken from the patient&#39;s tumor and enriched in a laboratory to higher fight the cancer.[/caption]</p>
<p>This is the longer term of medication, experts agree.  But the associated fee of this recent class of medical treatment raises concerns about availability and affordability, whilst its potential grows.</p>
<p>“Cell and gene therapies can change the lives of thousands of people, but only if we ensure sustainable access to them for all patients,” said Sarah Emond, president of the influential organization <a href="https://icer.org" target="_blank" rel="noopener">Institute for Clinical and Economic Review</a>a Boston-based nonprofit organization <a href="https://icer.org/news-insights/press-releases/icer-and-newdigs-release-white-paper-analyzing-the-challenges-and-potential-policy-options-for-paying-for-gene-therapies/" target="_blank" rel="noopener">assesses the worth of medicines.</a></p>
<p>The prices aren&#8217;t yet prohibitive because so few persons are currently being treated.  Patients must travel to specific treatment centers and aren&#8217;t referred by general practitioners.  But referrals and demand should increase as more treatments are introduced to serve a broader population.</p>
<p>Most health insurers within the United States aren&#8217;t designed to support one-time personal therapies that provide long-term advantages at unprecedented prices.</p>
<p><img decoding="async" class="alignright size-article_inline_half lazyautosizes lazyload" alt="Price table for various cell therapy treatments for rare complaints" data-sizes="auto" src="https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CELLTHERAPY-0512-91.jpg?fit=620%2C9999px&#038;ssl=1" data-attachment-id="10693288" srcset="https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CELLTHERAPY-0512-91.jpg?fit=620%2C9999px&#038;ssl=1 620w,https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CELLTHERAPY-0512-91.jpg?fit=310%2C9999px&#038;ssl=1 310w">“These are precision medicines,” he said <a href="https://med.stanford.edu/profiles/david-miklos" target="_blank" rel="noopener">David Miklos</a>, director of the Stanford Bone Marrow and Cell Therapy Program, where lots of of cancer patients have been treated with CAR T-cell therapies.  “It’s different than buying a pill at the CVS pharmacy that can work for everyone.”</p>
<p>The promise of cell and gene therapies has fascinated scientists for many years, but progress has been slow and fraught with setbacks.  Now the long research journey has finally paid off as FDA-approved products are entering the clinic.</p>
<p>“The technology to bring it to life has finally caught up with the ideas behind it,” said the Stanford assistant professor of medication <a href="https://med.stanford.edu/profiles/allison-betof-warner" target="_blank" rel="noopener">Dr.  Allison Betaf Warner</a>who conducts Stanford&#39;s melanoma study.</p>
<p>Cell-based strategies are delivering essentially the most famous cancer treatments in many years.</p>
<p>In an approach called chimeric antigen receptor (CAR) T-cell therapy, immune cells are collected from patients and genetically modified to higher fight lymphoma, leukemia and, more recently, multiple myeloma.</p>
<p>Another uses a special approach and uses tumor-infiltrating lymphocytes (TILs).  These immune cells are taken from the tumor, amplified within the laboratory after which given back to the patient.  In clinical studies, about 30% of patients experienced shrinkage or disappearance of the incurable melanoma tumors.</p>
<p>“I am very happy that it is here now.  &#8230; I walked the tightrope and didn&#39;t fall off,&#8221; said a Stanford patient who asked not to be named.</p>
<p>Gene therapy also uses manipulated cells in which genes are replaced, deleted or inserted.  Kendric Cromer, a 12-year-old boy from a suburb of Washington, DC, was born on Wednesday <a href="https://www.nytimes.com/2024/05/06/health/sickle-cell-cure-first.html" target="_blank" rel="noopener">the world&#39;s first person with sickle cell anemia to begin FDA-approved gene therapy.</a> Both Stanford and UCSF will offer this treatment.</p>
<figure id="attachment_10690783" class="wp-caption alignright size-article_inline_half"><img decoding="async" class="lazyload " alt="Dr.  Allison Betof Warner of Stanford Health Care provided a new cell-based therapy for a patient with metastatic melanoma who did not want to be identified.  The one-time treatment, which costs $515,000, uses immune cells harvested from the patient&#39;s tumor." width="3024" data-sizes="auto" src="https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_b887e6-rotated.jpg?fit=620%2C9999px&#038;ssl=1" data-attachment-id="10690783" srcset="https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_b887e6-rotated.jpg?fit=620%2C9999px&#038;ssl=1 620w,https://i0.wp.com/www.mercurynews.com/wp-content/uploads/2024/05/SJM-L-CAR-T-01_b887e6-rotated.jpg?fit=310%2C9999px&#038;ssl=1 310w"><figcaption class="wp-caption-text">Dr.  Allison Betof Warner of Stanford Health Care provided a new cell-based therapy for a patient with metastatic melanoma who did not want to be identified.  The one-time treatment, which costs $515,000, uses immune cells harvested from the patient&#39;s tumor.  Stanford Health Care</figcaption></figure>
<p>Scientists are now working to expand the therapeutic repertoire to combat solid tumors, autoimmune diseases, aging, HIV and more.</p>
<p>“It’s just the beginning of a new era,” said the biochemist <a href="https://limlab.ucsf.edu/people/wendell.html" goal="_blank" rel="noopener">Wendell Lim</a>Director of the UC San Francisco Cell Design Institute.</p>
<p>“It shows that we can take a living cell and change how it works so that it makes new decisions and performs complex actions.  It processes information like a small computer,” he said.  “That’s very different from a static thing, like a chemical.”</p>
<p>It&#39;s still early and few patients are taking advantage of these new breakthrough therapies, doctors said.</p>
<p>Why?  It is not yet known that sick people are not referred by their community doctors, said Miklos.  The treatment is risky.  Or patients may live far from the country&#39;s estimated 30 &#8220;centers of excellence&#8221; such as Stanford and UCSF and are put off by travel and accommodation costs.</p>
<p>Payment is not guaranteed;  it will be decided on a case by case basis.  Medicare and MediCal cover the cost of care if it is deemed medically necessary.  Emperor too.</p>
<p>The vast majority of private insurers cover treatments, although back-and-forth negotiations are sometimes required, said Gary Goldstein, who oversees operations for Stanford&#39;s Blood &#038; Marrow Transplant Program.</p>
<p>Sticker price covers parts only &#8211; no labor, no warranty.  Drug prices are not regulated like utilities are, and there is no cap on what a company can charge.</p>
<p>Estimates place the total cost of gene therapies over the next decade at a staggering $35 billion to $40 billion.  The cost of future cell therapies that could help a wider range of patients will likely be higher.</p>
<p>Drugmakers argue that the prices reflect the major clinical benefits as well as the risks and uncertainties of development.  They add that a one-time treatment for a chronic illness can actually save money by eliminating lifelong care.</p>
<p>“We have never cured patients with a single treatment,” he said <a href="https://www.ucsfhealth.org/providers/dr-gregory-allen" goal="_blank" rel="noopener">Dr.  Greg Allen from UCSF</a>, which is developing immune cell therapies for notoriously difficult-to-treat tumors such as those of the pancreas and lung.  “So it’s very exciting.”</p>
<p>For some patients, it could be their last best chance.</p>
<p>“I don’t believe that life has a price,” said Betof Warner of Stanford.  “These are patients who have no other choice.”</p>
<p>If millions of people are helped, as hoped, it will put budget pressure on the federal government and larger payers, while smaller employers, state Medicaid plans and regional health insurers may find providing access financially impossible, economists warn.  Health care costs are already outpacing inflation, rising 7% this year.</p>
<p>“It’s going to put a lot of strain on the system,” he said <a href="https://gufaculty360.georgetown.edu/s/contact/0033600001Yeok3AAB/edwin-park" goal="_blank" rel="noopener">Edwin Park at Georgetown University&#39;s McCourt School of Public Policy</a>.  “But the issue is critical because you don’t want the high price of these therapies to result in low-income people not having access to them.”</p>
<p>Governments and commercial insurers are already testing the effectiveness of treatments.  Some impose strict restrictions on eligibility.  They demand discounts and rebates from manufacturers.</p>
<p>If manufacturing were done locally — making the cells at Stanford or UCSF, for example, rather than at distant pharmaceutical companies — that would reduce costs, Miklos said.</p>
<p>As competition increases, prices will fall, he predicted.</p>
<p>Meanwhile, the health system needs to focus on finding innovative payment solutions, Emond said.</p>
<p>One suggestion is to amortize the amounts paid by insurers over time, similar to a home mortgage.  Another option is for pharmaceutical companies to provide a pro-rata reimbursement if a patient&#39;s condition does not improve &#8211; a &#8220;pay-for-performance&#8221; model.  Another option can be a subscription-based approach like Netflix, where insurers pay a monthly fee to get access to the quantity of therapy needed.</p>
<p>“As we look to the future,” Emond said, “this is a moment when we can discuss how we can do things differently.”</p>
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